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U. Motro, G. Thomson (1985)
The affected sib method. I. Statistical features of the affected sib-pair method.Genetics, 110 3
352-362. and a second unlinked locus
G. Thomson (1986)
Determining the mode of inheritance of RFLP-associated diseases using the affected sib-pair method.American journal of human genetics, 39 2
(1986)
The affected sib method . VII . Multi - allelic and multi - locus
A. Edwards (1971)
Distances between populations on the basis of gene frequencies.Biometrics, 27 4
(1982)
Differential penetrance and dose of susceptibility genes in insulin dependent diabetes
G. Thomson, W. Bodmer (1977)
The Genetics of HLA and Disease Associations
(1986)
The three allele synergistic mixed model for insulin dependent diabetes
Payami Payami, Thomson Thomson, Motro Motro, Louis Louis, Hudes Hudes (1985)
The affected sib method. IV. Affected sib triosAnn. Hum. Genet., 49
G. Thomson (2008)
Investigation of the mode of inheritance of the HLA associated diseases by the method of antigen genotype frequencies among diseased individuals.Tissue antigens, 21 2
N. Day, M. Simons (2008)
Disease susceptibility genes--their identification by multiple case family studies.Tissue antigens, 8 2
E. Louis, G. Thomson, H. Payami (1984)
Affected Sib Methods
J. Rotter, C. Anderson, Rachel Rubin, Jane Congleton, P. Terasaki, D. Rimoin (1983)
HLA Genotypic Study of Insulin-dependent Diabetes: The Excess of DR3/DR4 Heterozygotes Allows Rejection of the Recessive HypothesisDiabetes, 32
B. Suarez (1978)
The affected sib pair IBD distribution for HLA-linked disease susceptibility genes.Tissue antigens, 12 2
Louis Louis, Thomson Thomson (1986)
The three allele synergistic mixed model for insulin dependent diabetes mellitusDiabetes
B. Suarez, J. Crouse, P. Eerdewegh (1983)
HLA sharing in multiplex sibshipsAnnals of Human Genetics, 47
9 7 7~) . The genetics of HLA and disease associations. I n Measuring Selection in Natural Pcryulations
(1985)
The affected sib method
H. Payami, G. Thomson, E. Louis (1984)
The affected sib method. III. Selection and recombination.American journal of human genetics, 36 2
(1977)
The genetic analysis of HLA and disease
(1986)
Population genetic analysis of complex human traits
The genetic analysis of HLA and disease associations
Risch Risch (1985)
Affected sib pair marker allele sharing: the effect of reduced fertility, variable family size, and a second unlinked locusAm. J. Hum. Genet., 34
D. Bennett (1975)
The T-locus of the mouseCell, 6
R. Spielman, L. Baker, C. Zmijewski (1980)
Gene dosage and susceptibility to insulin‐dependent diabetesAnnals of Human Genetics, 44
E. Louis, G. Thomson, H. Payami (1983)
The affected sib method. II. The intermediate modelAnnals of Human Genetics, 47
(1985)
Affected sib pair marker allele sharing: the effect of reduced fertility, variable family size. studies
(1982)
. The excess of DR 3 / DR 4 heterozygotes allows rejection of the recessive hypothesis
H. Payami, Glenys Thomson, U. Motro, E. Louis, E. Hudes (1985)
The affected sib method. IV. Sib triosAnnals of Human Genetics, 49
R. Lewontin (1968)
THE EFFECT OF DIFFERENTIAL VIABILITY ON THE POPULATION DYNAMICS OF t ALLELES IN THE HOUSE MOUSEEvolution, 22
Summary The affected sib methods, which are used to make inferences about the genetic components of HLA associated diseases, have many underlying assumptions which may not always be realistic. These include no selective disadvantage of affected individuals, little or no recombination between the marker loci and the ‘disease’ locus, a single panmictic population, Mendelian segregation of the disease locus alleles and random distribution of individuals over environments. The effects of breaking these assumptions have been investigated. We have explicitly derived the haplotype sharing identity by descent (IBD) expectations for the cases of selection against affected individuals and recombination between the HLA marker loci and the ‘disease’ predisposing locus for affected sib trios (as was previously done for affected sib pairs). We have also derived, for both affected sib pairs and trios, the haplotype sharing expectations for non‐random mating (positive assortative), admixture, meiotic drive (of disease allele carrying haplotypes), and a random versus shared environmental component for sibs. In order to assess the sensitivity of the affected sib methods to perturbations in the assumptions, the expectation spaces of haplotype sharing in affected sib pairs and sib trios under the single diallelic locus model with varying penetrances and allele frequencies are fully described. The effects on haplotype sharing and subsequent disease parameter estimation are different for each of the factors we have considered. The affected sib methods are found to be robust in many situations.
Annals of Human Genetics – Wiley
Published: Jan 1, 1987
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