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T. Yanagimoto (1990)
Combining moment estimates of a parameter common through strataJournal of Statistical Planning and Inference, 25
(1991)
The role of unbiasedness in estimating equations
Haldane Haldane (1954)
An exact test for rendomness of matingJ. Genet., 52
V. Godambe (1960)
An Optimum Property of Regular Maximum Likelihood EstimationAnnals of Mathematical Statistics, 31
Ghosh Ghosh (1977)
Polymorphism of red cell glyoxalase 1 with special reference ot South and Southeast Asis and OceaniHum. Genet., 35
J. Thoday (1956)
Population GeneticsNature, 178
(1903)
The laws of Galton and Mendel and some laws governing race improvement by selection
Cedric Smith (1970)
A note on testing the Hardy‐Weinberg LawAnnals of Human Genetics, 33
Summary The problem of testing the Hardy‐Weinberg law when data are sampled from several populations with different allele frequencies is considered. An Odds‐ratio representation of disequilibrium is proposed. This ration is assumed to be constant across strata, an assumption that seems more reasonalbe than that of previous authors of a constant difference in true and expected (undre equilibrium) heterozygote proportions. A score‐type test which optimally combines information from the separate strata is then drived using the theory of unbiased estimating equations. Simulations show that the new test has greater power than previously proposed tests when the disequilibrium ratio is constant across strata. The method is applied to glyoxable genotype data form populations in India.
Annals of Human Genetics – Wiley
Published: Oct 1, 1993
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