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Testing the Hardy‐Weinberg law across strata

Testing the Hardy‐Weinberg law across strata Summary The problem of testing the Hardy‐Weinberg law when data are sampled from several populations with different allele frequencies is considered. An Odds‐ratio representation of disequilibrium is proposed. This ration is assumed to be constant across strata, an assumption that seems more reasonalbe than that of previous authors of a constant difference in true and expected (undre equilibrium) heterozygote proportions. A score‐type test which optimally combines information from the separate strata is then drived using the theory of unbiased estimating equations. Simulations show that the new test has greater power than previously proposed tests when the disequilibrium ratio is constant across strata. The method is applied to glyoxable genotype data form populations in India. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Testing the Hardy‐Weinberg law across strata

Annals of Human Genetics , Volume 57 (4) – Oct 1, 1993

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References (8)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1993.tb00903.x
Publisher site
See Article on Publisher Site

Abstract

Summary The problem of testing the Hardy‐Weinberg law when data are sampled from several populations with different allele frequencies is considered. An Odds‐ratio representation of disequilibrium is proposed. This ration is assumed to be constant across strata, an assumption that seems more reasonalbe than that of previous authors of a constant difference in true and expected (undre equilibrium) heterozygote proportions. A score‐type test which optimally combines information from the separate strata is then drived using the theory of unbiased estimating equations. Simulations show that the new test has greater power than previously proposed tests when the disequilibrium ratio is constant across strata. The method is applied to glyoxable genotype data form populations in India.

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1993

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