The Rh(III)‐catalyzed C−H annulation reactions of N‐aryl indazolones or N‐aryl phthalazinones with a vinylene carbonate is described herein. This transformation provides the rapid access to indazolocinnolines and phthalazinocinnolines as important assets towards the development of novel bioactive compounds. Intriguingly, a vinylene carbonate acts as a vinyl transfer agent to enable the [4+2] annulation reaction. This method is characterized by its simplicity, mild reaction conditions, and broad functional group tolerance.
Asian Journal of Organic Chemistry – Wiley
Published: Nov 1, 2021
Keywords: annulation; C−H functionalization; cinnoline; rhodium; vinylene carbonate