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Synthesis of 6‐Phenanthridinephosphonates via a Radical Phosphonation and Cyclization Process Mediated by Manganese(III) Acetate

Synthesis of 6‐Phenanthridinephosphonates via a Radical Phosphonation and Cyclization Process... 6‐Phenanthridinephosphonates have interesting biological activities and potential pharmaceutical applications. However, methods for preparing these compounds are very limited. In this report, dialkyl 6‐phenanthridinephosphonates were synthesized through Mn(OAc)3‐mediated radical phosphonation of 2‐isocyanobiaryls in good to excellent yields under relatively mild reaction conditions. As one of its notable features, the radical process allows the direct formation of a PC bond and the construction of a phenanthridine ring in one reaction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Synthesis of 6‐Phenanthridinephosphonates via a Radical Phosphonation and Cyclization Process Mediated by Manganese(III) Acetate

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References (61)

Publisher
Wiley
Copyright
Copyright © 2014 Wiley Subscription Services, Inc., A Wiley Company
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201402027
Publisher site
See Article on Publisher Site

Abstract

6‐Phenanthridinephosphonates have interesting biological activities and potential pharmaceutical applications. However, methods for preparing these compounds are very limited. In this report, dialkyl 6‐phenanthridinephosphonates were synthesized through Mn(OAc)3‐mediated radical phosphonation of 2‐isocyanobiaryls in good to excellent yields under relatively mild reaction conditions. As one of its notable features, the radical process allows the direct formation of a PC bond and the construction of a phenanthridine ring in one reaction.

Journal

Asian Journal of Organic ChemistryWiley

Published: Jun 1, 2014

Keywords: ; ; ; ;

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