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Synthesis, Bioactivity, and the Anion‐Binding Property of 2‐Sulfydryl‐1,3,4‐thiodiazole Derivatives

Synthesis, Bioactivity, and the Anion‐Binding Property of 2‐Sulfydryl‐1,3,4‐thiodiazole Derivatives ABSTRACT Two new compounds (1 and 2) containing 2‐sulfydryl‐1,3,4‐thiodiazole have been synthesized and optimized. They both showed wide antibacterial activity for colon bacillus, Staphylococcus aureus, S. albus, dysentery bacillus and inferior activity for Bacillus subtilis. In addition, their binding properties were evaluated for biologically important anions (F–, Cl–, Br–, I–, AcO–, and H2PO4–) by theoretical investigation, UV–vis, fluorescence, and 1H NMR titration experiments, and they displayed strong binding ability for H2PO4– without the interference of other anions tested. Especially the binding ability of compound 2 containing anthracene with H2PO4– was 1000 times stronger than that of compound 1 containing nitrobenzene. Two compounds based on 2‐sulfydryl‐1,3,4‐thiodiazole have both properties of anion recognition and antibacterial activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heteroatom Chemistry Wiley

Synthesis, Bioactivity, and the Anion‐Binding Property of 2‐Sulfydryl‐1,3,4‐thiodiazole Derivatives

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References (25)

Publisher
Wiley
Copyright
Copyright © 2015 Wiley Periodicals, Inc.
ISSN
1042-7163
eISSN
1098-1071
DOI
10.1002/hc.21239
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Two new compounds (1 and 2) containing 2‐sulfydryl‐1,3,4‐thiodiazole have been synthesized and optimized. They both showed wide antibacterial activity for colon bacillus, Staphylococcus aureus, S. albus, dysentery bacillus and inferior activity for Bacillus subtilis. In addition, their binding properties were evaluated for biologically important anions (F–, Cl–, Br–, I–, AcO–, and H2PO4–) by theoretical investigation, UV–vis, fluorescence, and 1H NMR titration experiments, and they displayed strong binding ability for H2PO4– without the interference of other anions tested. Especially the binding ability of compound 2 containing anthracene with H2PO4– was 1000 times stronger than that of compound 1 containing nitrobenzene. Two compounds based on 2‐sulfydryl‐1,3,4‐thiodiazole have both properties of anion recognition and antibacterial activity.

Journal

Heteroatom ChemistryWiley

Published: Mar 1, 2015

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