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C. Shishoo, M. Devani, G. Ullas, S. Ananthan, V. Bhadti (1985)
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Several derivatives containing the thieno(2,3‐d)pyrimidine system were prepared starting from 2‐amino‐4,5‐dihydronaphtho(2,1‐b)thiophene‐1‐carbonitrile (1). In particular, the synthesis and structure characterization of 8,9‐dihydronaphtho‐ (1′,2′:4,5)thieno(3,2‐e)(1,2,4)triazolo(4,3‐c)pyrimidine derivatives 13–16 and their isomerization to 8,9‐dihydronaphtho(1′,2′:4,5)thieno(3,2‐e)(1,2,4)‐triazolo(1,5‐c)pyrimidine derivatives 17–20 under different suitable reaction conditions were reported and verified with X‐ray analysis. Moreover, compounds 13, 14 and 22 were tested as potential anti‐inflammatory agents and derivative 14 showed potent activity in carrageenan test. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:226–234, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20114
Heteroatom Chemistry – Wiley
Published: Jan 1, 2005
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