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Synthesis and isomerization of thienotriazolopyrimidine and thienotetrazolopyrimidine derivatives with potential anti‐inflammatory activity

Synthesis and isomerization of thienotriazolopyrimidine and thienotetrazolopyrimidine derivatives... Several derivatives containing the thieno(2,3‐d)pyrimidine system were prepared starting from 2‐amino‐4,5‐dihydronaphtho(2,1‐b)thiophene‐1‐carbonitrile (1). In particular, the synthesis and structure characterization of 8,9‐dihydronaphtho‐ (1′,2′:4,5)thieno(3,2‐e)(1,2,4)triazolo(4,3‐c)pyrimidine derivatives 13–16 and their isomerization to 8,9‐dihydronaphtho(1′,2′:4,5)thieno(3,2‐e)(1,2,4)‐triazolo(1,5‐c)pyrimidine derivatives 17–20 under different suitable reaction conditions were reported and verified with X‐ray analysis. Moreover, compounds 13, 14 and 22 were tested as potential anti‐inflammatory agents and derivative 14 showed potent activity in carrageenan test. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:226–234, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20114 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heteroatom Chemistry Wiley

Synthesis and isomerization of thienotriazolopyrimidine and thienotetrazolopyrimidine derivatives with potential anti‐inflammatory activity

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References (16)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Periodicals, Inc.
ISSN
1042-7163
eISSN
1098-1071
DOI
10.1002/hc.20114
Publisher site
See Article on Publisher Site

Abstract

Several derivatives containing the thieno(2,3‐d)pyrimidine system were prepared starting from 2‐amino‐4,5‐dihydronaphtho(2,1‐b)thiophene‐1‐carbonitrile (1). In particular, the synthesis and structure characterization of 8,9‐dihydronaphtho‐ (1′,2′:4,5)thieno(3,2‐e)(1,2,4)triazolo(4,3‐c)pyrimidine derivatives 13–16 and their isomerization to 8,9‐dihydronaphtho(1′,2′:4,5)thieno(3,2‐e)(1,2,4)‐triazolo(1,5‐c)pyrimidine derivatives 17–20 under different suitable reaction conditions were reported and verified with X‐ray analysis. Moreover, compounds 13, 14 and 22 were tested as potential anti‐inflammatory agents and derivative 14 showed potent activity in carrageenan test. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:226–234, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20114

Journal

Heteroatom ChemistryWiley

Published: Jan 1, 2005

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