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Synthesis and in vitro antibacterial evaluation of 1‐substituted‐4‐ethoxycarbonylmethylthiosemicarbazides and products of their dehydrocyclization

Synthesis and in vitro antibacterial evaluation of... A series of s‐triazoles and thiohydantoines were synthesized by dehydrocyclization of 1‐substituted‐4‐ethoxycarbonylmethylthiosemicarbazides. The molecular structure proposed for s‐triazoles was confirmed by the X‐ray crystal structure analysis of one compound that was prone to crystallization. All compounds were tested in vitro for their antibacterial activity. Some of them showed low levels of activity against Gram‐positive species, MIC range 100–400 μg/mL or higher. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:131–138, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20597 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heteroatom Chemistry Wiley

Synthesis and in vitro antibacterial evaluation of 1‐substituted‐4‐ethoxycarbonylmethylthiosemicarbazides and products of their dehydrocyclization

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References (18)

Publisher
Wiley
Copyright
Copyright © 2010 Wiley Periodicals, Inc.
ISSN
1042-7163
eISSN
1098-1071
DOI
10.1002/hc.20597
Publisher site
See Article on Publisher Site

Abstract

A series of s‐triazoles and thiohydantoines were synthesized by dehydrocyclization of 1‐substituted‐4‐ethoxycarbonylmethylthiosemicarbazides. The molecular structure proposed for s‐triazoles was confirmed by the X‐ray crystal structure analysis of one compound that was prone to crystallization. All compounds were tested in vitro for their antibacterial activity. Some of them showed low levels of activity against Gram‐positive species, MIC range 100–400 μg/mL or higher. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:131–138, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20597

Journal

Heteroatom ChemistryWiley

Published: Jan 1, 2010

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