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Synthesis and bioactivities of novel organogermanium sesquioxides containing α ‐aminophosphonate groups

Synthesis and bioactivities of novel organogermanium sesquioxides containing α ‐aminophosphonate... In order to search for novel antitumor drugs with high activity and low toxicity, a series of novel organogermanium sesquioxides containing α‐aminophosphonate groups were synthesized by the hydrolysis of O,O‐diphenyl N‐trichlorogermylpropiono‐α‐aminophosphonates. Their structures were confirmed by 1H NMR, 31P NMR, and IR spectroscopy and by elemental analysis. Data of 1H NMR and IR spectroscopy indicated that the title compounds are polymeric organogermanium sesquioxides. The results of bioassay showed that the products possess potential anticancer activities. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 209–212, 1999 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heteroatom Chemistry Wiley

Synthesis and bioactivities of novel organogermanium sesquioxides containing α ‐aminophosphonate groups

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References (2)

Publisher
Wiley
Copyright
Copyright © 1999 John Wiley & Sons, Inc.
ISSN
1042-7163
eISSN
1098-1071
DOI
10.1002/(SICI)1098-1071(1999)10:3<209::AID-HC6>3.0.CO;2-G
Publisher site
See Article on Publisher Site

Abstract

In order to search for novel antitumor drugs with high activity and low toxicity, a series of novel organogermanium sesquioxides containing α‐aminophosphonate groups were synthesized by the hydrolysis of O,O‐diphenyl N‐trichlorogermylpropiono‐α‐aminophosphonates. Their structures were confirmed by 1H NMR, 31P NMR, and IR spectroscopy and by elemental analysis. Data of 1H NMR and IR spectroscopy indicated that the title compounds are polymeric organogermanium sesquioxides. The results of bioassay showed that the products possess potential anticancer activities. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 209–212, 1999

Journal

Heteroatom ChemistryWiley

Published: Jan 1, 1999

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