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Synergistic Catalysis with Azomethine Ylides

Synergistic Catalysis with Azomethine Ylides Azomethine ylides are useful intermediates for the rapid construction of chiral N‐containing compounds. However, its synthetic potential has not been fully developed due to the limited reaction models. In combination with synergistic catalysis and azomethine ylide chemistry, we have developed several types of novel catalytic system including Cu/Pd, Cu/Ir and PTC/Ir catalysis, which can convert readily‐available azomethine ylides to various high‐valued molecules such as unnatural α‐amino acids, homoallylic amines and N‐heterocycles. Compared with the traditional mono‐catalysis, the synergistic catalyst system exhibits enhanced catalytic efficiency and chiral induction ability in many cases. In addition, we have demonstrated that these strategies could be applied in the construction of bioactive compounds and natural products. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chinese Journal of Chemistry Wiley

Synergistic Catalysis with Azomethine Ylides

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References (31)

Publisher
Wiley
Copyright
© 2021 SIOC, CAS, Shanghai and Wiley‐VCH Verlag GmbH
ISSN
1001-604X
eISSN
1614-7065
DOI
10.1002/cjoc.202000380
Publisher site
See Article on Publisher Site

Abstract

Azomethine ylides are useful intermediates for the rapid construction of chiral N‐containing compounds. However, its synthetic potential has not been fully developed due to the limited reaction models. In combination with synergistic catalysis and azomethine ylide chemistry, we have developed several types of novel catalytic system including Cu/Pd, Cu/Ir and PTC/Ir catalysis, which can convert readily‐available azomethine ylides to various high‐valued molecules such as unnatural α‐amino acids, homoallylic amines and N‐heterocycles. Compared with the traditional mono‐catalysis, the synergistic catalyst system exhibits enhanced catalytic efficiency and chiral induction ability in many cases. In addition, we have demonstrated that these strategies could be applied in the construction of bioactive compounds and natural products.

Journal

Chinese Journal of ChemistryWiley

Published: Jan 1, 2021

Keywords: ; ; ; ;

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