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W. Davies, J. Maclaren, L. Wilkinson (1950)
687. The synthesis and properties of 2 : 4-diaminothiazolesJournal of The Chemical Society (resumed)
C. Lambert, M. Wilhelm, H. Striebel, F. Kradolfer, P. Schmidt (1964)
Eine neue gegen Bilharziose und Amoebiase wirksame VerbindungExperientia, 20
J. Koster, P. Biemond, A. Swaak (1986)
Intracellular and extracellular sulphydryl levels in rheumatoid arthritis.Annals of the Rheumatic Diseases, 45
P. Perrin, S. Phillips (1989)
The molecular basis of granuloma formation in schistosomiasis. III. In vivo effects of a T cell-derived suppressor effector factor and IL-2 on granuloma formation.Journal of immunology, 143 2
J. Pellegrino, C. Oliveira, J. Faria, A. Cunha (1962)
New approach to the screening of drugs in experimental schistosomiasis mansoni in mice.The American journal of tropical medicine and hygiene, 11
P. Skelly, L. Stein, C. Shoemaker (1993)
Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation.Molecular and biochemical parasitology, 60 1
Z. Andrade, W. Abreu (1971)
Follicular lymphoma of the spleen in patients with hepatosplenic Schistosomiasis mansoni.The American journal of tropical medicine and hygiene, 20 2
Y. Cha, J. Byram, H. Heine, E. Bueding (1980)
Effect of Schistosoma mansoni infection on hepatic drug-metabolizing capacity of athymic nude mice.The American journal of tropical medicine and hygiene, 29 2
B. Ketterer (1988)
Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis.Mutation research, 202 2
N. El-Badrawy, A. Hadi, B. Voss, A. Metwally, F. Ebeid (1991)
Effect of praziquantel on the distribution of interstitial collagen types I and III and basement membrane collagen types IV and V in murine hepatic schistosomiasis.Transactions of the Royal Society of Tropical Medicine and Hygiene, 85 6
D. Engels, L. Chitsulo, A. Montresor, L. Savioli (2002)
The global epidemiological situation of schistosomiasis and new approaches to control and research.Acta tropica, 82 2
S. Sheweita, S. Mangoura, A. El-Shemi (1998)
Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymesJournal of Helminthology, 72
A. Land, C. Ziegler, J. Sprague (1946)
Derivatives of sulfathiazole.The Journal of organic chemistry, 11 5
A. Yarinsky, H. Drobeck, H. Freele, J. Wiland, K. Gumaer (1974)
An 18-month study of the parasitologic and tumorigenic effects of hycanthone in Schistosoma mansoni-infected and noninfected mice.Toxicology and applied pharmacology, 27 1
G. Ellman (1959)
Tissue sulfhydryl groups.Archives of biochemistry and biophysics, 82 1
K. Gewald (1966)
Heterocyclen aus CH‐aciden Nitrilen. IV. Addition von Schwefelkohlenstoff an Alkylidenmalonitrile und ‐cyanessigesterJournal Fur Praktische Chemie-chemiker-zeitung, 31
L. Savioli, E. Renganathan, A. Montresor, A. Davis, K. Behbehani (1997)
Control of schistosomiasis--a global picture.Parasitology today, 13 11
R. Duvall, W. Dewitt (1967)
An improved perfusion technique for recovering adult schistosomes from laboratory animals.The American journal of tropical medicine and hygiene, 16 4
K. Kloetzel (1967)
A suggestion for the prevention of severe clinical forms of schistosomiasis mansoni.Bulletin of the World Health Organization, 37 4
R. Flaig, H. Hartmann (1997)
On the reaction of 2-amino-4-thiazoliniminium salts with active methylene compoundsMonatshefte für Chemie / Chemical Monthly, 128
R. Gönnert, P. Andrews (1977)
Praziquantel, a new broad-spectrum antischistosomal agentZeitschrift für Parasitenkunde, 52
Harry Husdan, Abraham Rapoport (1968)
Estimation of creatinine by the Jaffe reaction. A comparison of three methods.Clinical chemistry, 14 3
L. Chitsulo, D. Engels, A. Montresor, L. Savioli (2000)
The global status of schistosomiasis and its control.Acta tropica, 77 1
L. Werbel, E. Elslager, A. Phillips, D. Worth, P. Islip, M. Neville (1969)
2-(alkyl- and arylamino)-5-nitrothiazole derivatives with antiamebic, antitrichomonal, and antimalarial properties.Journal of medicinal chemistry, 12 3
S. Reitman, S. Frankel (1957)
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.American journal of clinical pathology, 28 1
P. Kind, E. King (1954)
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrineJournal of Clinical Pathology, 7
Schistosomiasis is considered one of the most important human helminth infection in terms of morbidity and infectivity (Chitsulo et al. Acta Trop 2000, 77, 41; Engles et al. Acta Trop 2002, 82, 139; Shelly et al. Mol Biochem Parasitol 1993, 60, 93). Derivatives of 2‐amino‐5‐nitrothiazoles have shown activity against Schistosoma mansoni (S. mansoni) and Schistosoma haematobium (S. haematobium), but due to their toxic effect we synthesized new derivatives of a heteroaromatic amine with thiazole moiety. Required thiazole derivatives were prepared via 1 and 2. In this work, two batches of animals were used to test the efficacy of 10 derivatives of thiazole against schistosomiasis. The first batch of Swiss albino mice was infected with S. mansoni and was treated with 5 × 50 mg/kg b.w. The second batch of golden hamsters was infected with S. haematobium and was treated with 5 × 100 mg/kg b.w. Parasitological parameters, biochemical studies, and granuloma diameter were estimated. Results indicated that in the case of S. mansoni infected mice, compounds 2 (2‐amino‐4‐thiazoliniminium chloride) and 20 (2,4‐diamino thiazole) showed moderate efficacy (50% worm reduction). While compounds 18 (4‐dicyanomethylene‐4, 5‐dihydrothiazo‐2‐yl)‐N,N‐dimethylimidoformamide) and 21 2‐(dimethylamino) methylene‐1,3‐thiazol‐4‐yl)‐N,N‐dimethylimidoformamide) showed 83% and 90% worm reduction with some normalization of liver function and significant reduction in hepatic granuloma diameters. In the case of S. haematobium infected hamsters, compound 15 showed reduction of worms by about 50% with improvement in kidney function. The high effect of compounds 18 and 21 compared to 2, 15, and 20 could be attributed to the dimethylimidoformamide moieties combined with the thiazole ring. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:121–222, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20072
Heteroatom Chemistry – Wiley
Published: Jan 1, 2005
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