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Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5‐amino‐6‐(5‐phosphoribosylamino)uracil reductase from Acinetobacter baumannii

Structure of diaminohydroxyphosphoribosylaminopyrimidine... The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5‐amino‐6‐(5‐phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 Å resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine‐binding site of the reductase domain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Crystallographica Section F Wiley

Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5‐amino‐6‐(5‐phosphoribosylamino)uracil reductase from Acinetobacter baumannii

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References (40)

Publisher
Wiley
Copyright
© Dawson et al. 2013
ISSN
1744-3091
eISSN
1744-3091
DOI
10.1107/S174430911301292X
pmid
23722836
Publisher site
See Article on Publisher Site

Abstract

The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5‐amino‐6‐(5‐phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 Å resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine‐binding site of the reductase domain.

Journal

Acta Crystallographica Section FWiley

Published: Jun 1, 2013

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