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- Publisher
- Wiley
- Copyright
- International Union of Crystallography, 2008
- ISSN
- 1744-3091
- eISSN
- 1744-3091
- DOI
- 10.1107/S1744309108027048
- pmid
- 18931427
- Publisher site
- See Article on Publisher Site
Abstract
The X‐ray crystal structure of the 6‐pyruvoyltetrahydropterin synthase (PTPS) homolog from Streptomyces coelicolor, SCO 6650, was solved at 1.5 Å resolution. SCO 6650 forms a hexameric T‐fold that closely resembles other PTPS proteins. The biological activity of SCO 6650 is unknown, but it lacks both a required active‐site zinc metal ion and the essential catalytic triad and does not catalyze the PTPS reaction. However, SCO 6650 maintains active‐site residues consistent with binding a pterin‐like substrate.
Journal
Acta Crystallographica Section F – Wiley
Published: Oct 1, 2008