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Yifang Yang, Bimal Koirala, Lucia Sanchez, N. Phillips, Sally Hamry, Yftah Tal‐Gan (2017)
Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross-group ComD Receptor Activation.ACS chemical biology, 12 4
L. Kim, L. McGee, S. Tomczyk, B. Beall (2016)
Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States PerspectiveClinical Microbiology Reviews, 29
Manibarsha Goswami, Adeline Espinasse, Erin Carlson (2018)
Disarming the virulence arsenal of Pseudomonas aeruginosa by blocking two-component system signaling† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02496kChemical Science, 9
Bimal Koirala, Yftah Tal‐Gan (2020)
Development of Streptococcus pneumoniae Pan‐Group Quorum‐Sensing ModulatorsChemBioChem, 21
Y. Ibrahim, A. Kerr, J. McCluskey, T. Mitchell (2004)
Role of HtrA in the Virulence and Competence of Streptococcus pneumoniaeInfection and Immunity, 72
L. Håvarstein, R. Hakenbeck, P. Gaustad (1997)
Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchangesJournal of Bacteriology, 179
Dominic McBrayer, Crissey Cameron, Yftah Tal‐Gan (2020)
Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria.Organic & biomolecular chemistry
Myeong Lee, D. Morrison (1999)
Identification of a New Regulator inStreptococcus pneumoniae Linking Quorum Sensing to Competence for Genetic TransformationJournal of Bacteriology, 181
I. Mortier-Barrière, A. Saizieu, J. Claverys, B. Martin (1998)
Competence‐specific induction of recA is required for full recombination proficiency during transformation in Streptococcus pneumoniaeMolecular Microbiology, 27
Bimal Koirala, Jingjun Lin, G. Lau, Yftah Tal‐Gan (2018)
Development of a Dominant Negative Competence‐Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute PneumoniaChemBioChem, 19
Yanni Liu, Yuna Zeng, Yijia Huang, L. Gu, Shaolin Wang, Chunhao Li, D. Morrison, Haiteng Deng, Jing-Ren Zhang (2019)
HtrA‐mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformationMolecular Microbiology, 112
Kaelyn Wilke, Conrad Fihn, Erin Carlson (2018)
Screening serine/threonine and tyrosine kinase inhibitors for histidine kinase inhibition.Bioorganic & medicinal chemistry, 26 19
M. Hutchings, A. Truman, B. Wilkinson (2019)
Antibiotics: past, present and future.Current opinion in microbiology, 51
A. Bryskier (2002)
Viridans group streptococci: a reservoir of resistant bacteria in oral cavities.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 8 2
Arnau Domenech, J. Slager, J. Veening (2018)
Antibiotic-Induced Cell Chaining Triggers Pneumococcal Competence by Reshaping Quorum Sensing to Autocrine-Like SignalingCell Reports, 25
Michael Kohanski, D. Dwyer, J. Collins (2010)
How antibiotics kill bacteria: from targets to networksNature Reviews Microbiology, 8
Nicolas Mirouze, M. Bergé, Anne-Lise Soulet, I. Mortier-Barrière, Y. Quentin, G. Fichant, C. Granadel, M. Noirot-Gros, P. Noirot, P. Polard, B. Martin, J. Claverys (2012)
Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competenceProceedings of the National Academy of Sciences, 110
R. Aminov (2010)
A Brief History of the Antibiotic Era: Lessons Learned and Challenges for the FutureFrontiers in Microbiology, 1
N. Croucher, S. Harris, C. Fraser, M. Quail, J. Burton, M. Linden, L. McGee, A. Gottberg, Jae-Hoon Song, K. Ko, B. Pichon, S. Baker, C. Parry, L. Lambertsen, D. Shahinas, D. Pillai, T. Mitchell, G. Dougan, A. Tomasz, K. Klugman, J. Parkhill, W. Hanage, S. Bentley (2011)
Rapid Pneumococcal Evolution in Response to Clinical InterventionsScience, 331
J. Claverys, B. Martin, P. Polard (2009)
The genetic transformation machinery: composition, localization, and mechanism.FEMS microbiology reviews, 33 3
J. Rosch, E. Tuomanen (2020)
Caging and COM-Bating Antibiotic Resistance.Cell host & microbe, 27 4
M. Sebert, L. Palmer, M. Rosenberg, J. Weiser (2002)
Microarray-Based Identification of htrA, a Streptococcus pneumoniae Gene That Is Regulated by the CiaRH Two-Component System and Contributes to Nasopharyngeal ColonizationInfection and Immunity, 70
S. Peterson, C. Sung, R. Cline, B. Desai, E. Snesrud, Ping Luo, Jennifer Walling, Haiying Li, M. Mintz, G. Tsegaye, Patrick Burr, Yu Do, Su-Hyeon Ahn, J. Gilbert, R. Fleischmann, D. Morrison (2004)
Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarraysMolecular Microbiology, 51
Maya Farha, C. Verschoor, D. Bowdish, E. Brown (2013)
Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus.Chemistry & biology, 20 9
L. Håvarstein, B. Martin, O. Johnsborg, C. Granadel, J. Claverys (2006)
New insights into the pneumococcal fratricide: relationship to clumping and identification of a novel immunity factorMolecular Microbiology, 59
B. Wahl, K. O'Brien, A. Greenbaum, Anwesha Majumder, Li Liu, Y. Chu, I. Lukšić, H. Nair, D. McAllister, H. Campbell, I. Rudan, R. Black, M. Knoll (2018)
Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15The Lancet. Global Health, 6
S. Shekhar, Rabia Khan, D. Ferreira, E. Mitsi, E. German, G. Rørvik, D. Berild, K. Schenck, K. Kwon, F. Petersen (2018)
Antibodies Reactive to Commensal Streptococcus mitis Show Cross-Reactivity With Virulent Streptococcus pneumoniae SerotypesFrontiers in Immunology, 9
Y. Ibrahim, A. Kerr, J. McCluskey, T. Mitchell (2004)
Control of Virulence by the Two-Component System CiaR/H Is Mediated via HtrA, a Major Virulence Factor of Streptococcus pneumoniaeJournal of Bacteriology, 186
J. Claverys, M. Prudhomme, B. Martin (2006)
Induction of competence regulons as a general response to stress in gram-positive bacteria.Annual review of microbiology, 60
Francis Hui, Lixin Zhou, D. Morrison (1995)
Competence for genetic transformation in Streptococcus pneumoniae: organization of a regulatory locus with homology to two lactococcin A secretion genes.Gene, 153 1
M. Dawson, R. Sia (1931)
IN VITRO TRANSFORMATION OF PNEUMOCOCCAL TYPES : I. A TECHNIQUE FOR INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES IN VITRO.Journal of Experimental Medicine, 54
Biol
Surya Aggarwal, Rory Eutsey, Jacob West-Roberts, Arnau Domenech, Wenjie Xu, I. Abdullah, A. Mitchell, J. Veening, H. Yesilkaya, N. Hiller (2018)
Function of BriC peptide in the pneumococcal competence and virulence portfolioPLoS Pathogens, 14
Arnau Domenech, Ana Brochado, V. Sender, K. Hentrich, B. Henriques-Normark, Athanasios Typas, J. Veening (2020)
Proton Motive Force Disruptors Block Bacterial Competence and Horizontal Gene Transfer.Cell host & microbe
Luchang Zhu, Jingjun Lin, Zhizhou Kuang, J. Vidal, G. Lau (2015)
Deletion analysis of Streptococcus pneumoniae late competence genes distinguishes virulence determinants that are dependent or independent of competence inductionMolecular Microbiology, 97
Ping Luo, Haiying Li, D. Morrison (2003)
ComX is a unique link between multiple quorum sensing outputs and competence in Streptococcus pneumoniaeMolecular Microbiology, 50
Stefany Moreno-Gámez, R. Sorg, Arnau Domenech, Arnau Domenech, M. Kjos, M. Kjos, F. Weissing, G. Doorn, J. Veening, J. Veening (2016)
Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competenceNature Communications, 8
Gianni Pozzi, L. Masala, F. Iannelli, Riccardo Manganelli, L. Håvarstein, L. Piccoli, D. Simon, Donald Morrison (1996)
Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromoneJournal of Bacteriology, 178
Yifang Yang, Yftah Tal‐Gan (2019)
Exploring the competence stimulating peptide (CSP) N-terminal requirements for effective ComD receptor activation in group1 Streptococcus pneumoniae.Bioorganic chemistry, 89
G. Salvadori, R. Junges, D. Morrison, F. Petersen (2019)
Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and ImplicationsFrontiers in Cellular and Infection Microbiology, 9
Bimal Koirala, N. Phillips, Yftah Tal‐Gan (2019)
Unveiling the Importance of Amide Protons in CSP:ComD Interactions in Streptococcus pneumoniae.ACS medicinal chemistry letters, 10 6
L. Håvarstein, Gowri. Coomaraswamy, D. Morrison (1995)
An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.Proceedings of the National Academy of Sciences of the United States of America, 92 24
Sébastien Guiral, T. Mitchell, B. Martin, J. Claverys (2005)
Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements.Proceedings of the National Academy of Sciences of the United States of America, 102 24
J. Claverys, B. Martin, L. Håvarstein (2007)
Competence‐induced fratricide in streptococciMolecular Microbiology, 64
J. Liñares, J. Liñares, C. Ardanuy, C. Ardanuy, R. Pallarés, R. Pallarés, A. Fenoll (2010)
Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 16 5
F. Griffith (1928)
The Significance of Pneumococcal TypesJournal of Hygiene, 27
M. Oggioni, Claudia Trappetti, A. Kadioglu, M. Cassone, F. Iannelli, S. Ricci, P. Andrew, G. Pozzi (2006)
Switch from planktonic to sessile life: a major event in pneumococcal pathogenesisMolecular Microbiology, 61
Yifang Yang, Gabriel Cornilescu, Yftah Tal‐Gan (2018)
Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae.Biochemistry, 57 36
Manibarsha Goswami, Kaelyn Wilke, Erin Carlson (2017)
Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.Journal of medicinal chemistry, 60 19
Laura Marks, Ryan Reddinger, A. Hakansson (2012)
High Levels of Genetic Recombination during Nasopharyngeal Carriage and Biofilm Formation in Streptococcus pneumoniaemBio, 3
Anders Jensen, Óskar Valdórsson, N. Frimodt-Møller, S. Hollingshead, M. Kilian (2015)
Commensal Streptococci Serve as a Reservoir for β-Lactam Resistance Genes in Streptococcus pneumoniaeAntimicrobial Agents and Chemotherapy, 59
Calum Johnston, B. Martin, G. Fichant, P. Polard, J. Claverys (2014)
Bacterial transformation: distribution, shared mechanisms and divergent controlNature Reviews Microbiology, 12
M. Prudhomme, L. Attaiech, G. Sanchez, B. Martin, J. Claverys (2006)
Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniaeScience, 313
P. Suntharalingam, D. Cvitkovitch (2005)
Quorum sensing in streptococcal biofilm formation.Trends in microbiology, 13 1
Yifang Yang, Jingjun Lin, A. Harrington, Gabriel Cornilescu, G. Lau, Yftah Tal‐Gan (2020)
Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniaeProceedings of the National Academy of Sciences, 117
T. Kochan, S. Dawid (2013)
The HtrA Protease of Streptococcus pneumoniae Controls Density-Dependent Stimulation of the Bacteriocin blp Locus via Disruption of Pheromone SecretionJournal of Bacteriology, 195
J. Claverys, M. Prudhomme, I. Mortier-Barrière, B. Martin (2000)
Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination‐mediated genetic plasticity?Molecular Microbiology, 35
(2014)
Biochemistry from Acharya Nagarjuna University, India, and MS (2010) in Biochemistry from Andhra University, India
M. Blokesch (2016)
Natural competence for transformationCurrent Biology, 26
G. Lau, S. Haataja, M. Lonetto, Sarah Kensit, A. Marra, A. Bryant, D. McDevitt, D. Morrison, D. Holden (2001)
A functional genomic analysis of type 3 Streptococcus pneumoniae virulenceMolecular Microbiology, 40
Bimal Koirala, R. Hillman, Erin Tiwold, M. Bertucci, Yftah Tal‐Gan (2018)
Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniaeBeilstein Journal of Organic Chemistry, 14
Kaelyn Wilke, Samson Francis, Erin Carlson (2014)
Inactivation of Multiple Bacterial Histidine Kinases by Targeting the ATP-Binding DomainACS Chemical Biology, 10
J. Kowalko, M. Sebert, M. Sebert (2008)
The Streptococcus pneumoniae Competence Regulatory System Influences Respiratory Tract ColonizationInfection and Immunity, 76
A. Gómez-Mejia, Gustavo Gámez, S. Hammerschmidt (2017)
Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment.International journal of medical microbiology : IJMM, 308 6
Médéric Diard, W. Hardt (2017)
Evolution of bacterial virulence.FEMS microbiology reviews, 41 5
Yashuan Chao, Laura Marks, M. Pettigrew, A. Hakansson (2015)
Streptococcus pneumoniae biofilm formation and dispersion during colonization and diseaseFrontiers in Cellular and Infection Microbiology, 4
J. Weiser (2010)
The pneumococcus: why a commensal misbehavesJournal of Molecular Medicine, 88
A. Santos-Lopez, Christopher Marshall, Michelle Scribner, D. Snyder, V. Cooper (2019)
Biofilm-dependent evolutionary pathways to antibiotic resistancebioRxiv
C. Duan, Luchang Zhu, Ying Xu, G. Lau (2012)
Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic TransformationPLoS ONE, 7
M. Sebert, K. Patel, M. Plotnick, J. Weiser (2005)
Pneumococcal HtrA Protease Mediates Inhibition of Competence by the CiaRH Two-Component Signaling SystemJournal of Bacteriology, 187
M. Bartilson, A. Marra, J. Christine, Jyoti Asundi, W. Schneider, A. Hromockyj (2001)
Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptideMolecular Microbiology, 39
Luchang Zhu, G. Lau (2011)
Inhibition of Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus pneumoniae by a Modified Competence Stimulating PeptidePLoS Pathogens, 7
S. Dawid, M. Sebert, J. Weiser (2008)
Bacteriocin Activity of Streptococcus pneumoniae Is Controlled by the Serine Protease HtrA via Posttranscriptional RegulationJournal of Bacteriology, 191
E. Donkor, C. Bishop, K. Gould, Jason Hinds, Martin Antonio, Brendan Wren, W. Hanage (2011)
High Levels of Recombination among Streptococcus pneumoniae Isolates from the GambiamBio, 2
C. Chewapreecha, S. Harris, N. Croucher, C. Turner, P. Marttinen, Lu Cheng, A. Pessia, D. Aanensen, A. Mather, A. Page, S. Salter, D. Harris, F. Nosten, D. Goldblatt, J. Corander, J. Parkhill, P. Turner, S. Bentley (2014)
Dense genomic sampling identifies highways of pneumococcal recombinationNature genetics, 46
A. Kadioglu, J. Weiser, J. Paton, P. Andrew (2008)
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and diseaseNature Reviews Microbiology, 6
Luchang Zhu, G. Lau (2013)
Therapeutic potential of the Streptococcus pneumoniae competence regulonExpert Review of Anti-infective Therapy, 11
Max Schroeder, D. Stephens (2005)
Macrolide Resistance in Streptococcus pneumoniaeFrontiers in Cellular and Infection Microbiology, 6
C. Janoir, I. Podglajen, M. Kitzis, C. Poyart, L. Gutmann (1999)
In vitro exchange of fluoroquinolone resistance determinants between Streptococcus pneumoniae and viridans streptococci and genomic organization of the parE-parC region in S. mitis.The Journal of infectious diseases, 180 2
Lavida Brooks, G. Mias (2018)
Streptococcus pneumoniae’s Virulence and Host Immunity: Aging, Diagnostics, and PreventionFrontiers in Immunology, 9
Tahmina Milly, Yftah Tal‐Gan (2020)
Biological evaluation of native streptococcal competence stimulating peptides reveals potential crosstalk between Streptococcus mitis and Streptococcus pneumoniae and a new scaffold for the development of S. pneumoniae quorum sensing modulatorsRSC Chemical Biology, 1
S. Kohler, Franziska Voß, Alejandro Mejia, Jeremy Brown, S. Hammerschmidt (2016)
Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasionFEBS Letters, 590
M. Kilian, K. Poulsen, Trinelise Blomqvist, L. Håvarstein, M. Bek-Thomsen, H. Tettelin, U. Sørensen (2008)
Evolution of Streptococcus pneumoniae and Its Close Commensal RelativesPLoS ONE, 3
Rolando Cuevas, Rory Eutsey, Anagha Kadam, Jacob West-Roberts, C. Woolford, A. Mitchell, K. Mason, N. Hiller (2017)
A novel streptococcal cell–cell communication peptide promotes pneumococcal virulence and biofilm formationMolecular Microbiology, 105
J. Slager, M. Kjos, L. Attaiech, J. Veening (2014)
Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the OriginCell, 157
E. Karlsson, D. Kwiatkowski, Pardis Sabeti (2014)
Natural selection and infectious disease in human populationsNature Reviews. Genetics, 15
Ola Ween, P. Gaustad, L. Håvarstein (1999)
Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniaeMolecular Microbiology, 33
M. Domenech, Ernesto García, M. Moscoso (2012)
Biofilm formation in Streptococcus pneumoniaeMicrobial biotechnology, 5
S. Mehr, N. Wood (2012)
Streptococcus pneumoniae--a review of carriage, infection, serotype replacement and vaccination.Paediatric respiratory reviews, 13 4
A. Whatmore, V. Barcus, C. Dowson (1999)
Genetic Diversity of the Streptococcal Competence (com) Gene LocusJournal of Bacteriology, 181
O. Johnsborg, P. Kristiansen, Trinelise Blomqvist, L. Håvarstein (2006)
A Hydrophobic Patch in the Competence-Stimulating Peptide, a Pneumococcal Competence Pheromone, Is Essential for Specificity and Biological ActivityJournal of Bacteriology, 188
K. Sturød, G. Salvadori, R. Junges, F. Petersen (2018)
Antibiotics alter the window of competence for natural transformation in streptococciMolecular Oral Microbiology, 33
M. Jedrzejas (2001)
Pneumococcal Virulence Factors: Structure and FunctionMicrobiology and Molecular Biology Reviews, 65
Streptococcus pneumoniae is an opportunistic respiratory human pathogen that poses a continuing threat to human health. Natural competence for genetic transformation in S. pneumoniae plays an important role in aiding pathogenicity and it is the best‐characterized feature to acquire antimicrobial resistance genes by a frequent process of recombination. In S. pneumoniae, competence, along with virulence factor production, is controlled by a cell‐density communication mechanism termed the competence regulon. In this review, we present the recent advances in the development of alternative methods to attenuate the pathogenicity of S. pneumoniae by targeting the various stages of the non‐essential competence regulon communication system. We mainly focus on new developments related to competitively intercepting the competence regulon signaling through the introduction of promising dominant‐negative Competence Stimulating Peptide (CSP) scaffolds. We also discuss recent reports on antibiotics that can block CSP export by disturbing the proton motive force across the membrane and various ways to control the pneumococcal pathogenicity by activating the counter signaling circuit and targeting the pneumococcal proteome.
Peptide Science – Wiley
Published: Jul 1, 2021
Keywords: ; ; ; ;
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