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(1963)
Introduction to the Theory of Statietics
- Publisher
- Wiley
- Copyright
- Copyright © 1976 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0003-4800
- eISSN
- 1469-1809
- DOI
- 10.1111/j.1469-1809.1976.tb00132.x
- Publisher site
- See Article on Publisher Site
Abstract
Summary If a disease can be split into two or more groups on any criterion (clinical, biochemical, physiological or statistical) then the grouping can be tested to establish if genetically independent forms of the disease have been identified. The data required are simply the frequencies of the two disease groups in relatives of probands for each of the disease groups. A systematic search for such distinct groups is proposed in searches for genetic heterogeneity in familial diseases.
Journal
Annals of Human Genetics – Wiley
Published: Jan 1, 1976