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G. Thomas, P. Lelkes, D. Chick, Huiping Lu, Thomas Kowal, R. Hammond, H. Nakajima, H. Nakajima, A. Spanta, L. Stephenson (1995)
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Introduction It has been over 12 years since Carpentier and Chachques' reported on the first patient to undergo cardiomyoplasty, a surgical procedure where the latissimus dorsi muscle is wrapped around the ventricles and then stimulated to contract during systole (Fig. 1). This operation has now been performed in more than a thousand patients worldwide.2 The Cardiomyoplasty Phase I clinical trial was conducted in this country under the auspices of the Food and Drug Administration between 1988 and 1991, and the Phase I1 trial from 1991 to 1993. The Phase I1 results were reported in 1996.3Currently, we are about 2 years into the Phase I11 trial, where 400patients are being randomized to either cardiomyoplasty or standard medical therapy for heart failure. The Phase 111 objective is to determine the safety and efficacy of cardiomyoplasty as a treatment for heart failure in patients with either idiopathic dilated cardiomyopathy or ischemic cardiomyopathy. In another procedure called aortomyoplasty, the muscle is wrapped around a portion of the aorta and then stimulated during cardiac diastole in hopes of augmenting aortic diastolic pressure (Fig. 2). That procedure has been performed in at least 28 patient^.^ What have we learned so far about cardiomyoplasty, aortomyoplasty,
Journal of Interventional Cardiology – Wiley
Published: Jun 1, 1998
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