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Coronary stenting can significantly reduce the restenosis and reocclusion rates after successful balloon angioplasty for chronic total occlusions (CTO). Nevertheless, recanalization of CTO remains among the worst predictors for in‐stent restenosis and reocclusion. This multicenter, nonrandomized study assessed the safety and effectiveness of the CYPHER® sirolimus‐eluting stent in reducing angiographic in‐stent late loss in totally occluded native coronary arteries. A total of 25 eligible patients were treated with the CYPHER® sirolimus‐eluting stent. Baseline clinical and angiographic data were collected and 6‐month follow‐up angiography and intravascular ultrasound (IVUS) were performed. Clinical follow‐up was required at 30 days, 6, 12, 18, and 24 months. Study stent implantation was successful in all patients, with a mean stent length of 28.4 ± 11 mm. Six‐month angiographic outcomes showed that mean lumen diameter stenosis did not change (2.22 ± 0.56 mm postprocedure; 2.26 ± 0.60 mm at 6 months follow‐up; P = NS). Similarly, mean percent diameter stenosis did not change significantly (15.7 ± 8.6% postprocedure, 19.3 ± 11% at follow‐up; P = NS). The absolute late lumen loss was −0.03 ± 0.28 mm with a 6‐month in‐stent restenosis rate of 0%. IVUS follow‐up revealed in‐stent obstruction volume of only 4.9 ± 6.8%. Long‐term clinical follow‐up showed target lesion revascularization at 12 months was only 4%, with target vessel revascularization of only 12%. The CYPHER® sirolimus‐eluting stent was safe and effective in the treatment of CTO compared to historical data with bare metal stents.
Journal of Interventional Cardiology – Wiley
Published: Aug 1, 2006
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