Access the full text.
Sign up today, get DeepDyve free for 14 days.
Y. Geinisman, J. Disterhoft, H. Gundersen, M. McEchron, Inna Persina, J. Power, E. Zee, M. West (2000)
Remodeling of hippocampal synapses after hippocampus‐dependent associative learningJournal of Comparative Neurology, 417
A. O'Malley, C. O'Connell, C. Regan (1998)
Ultrastructural analysis reveals avoidance conditioning to induce a transient increase in hippocampal dentate spine density in the 6hour post-training period of consolidationNeuroscience, 87
R. Barber, J. Vaughn, R. Wimer, C. Wimer (1974)
Genetically‐associated variations in the destribution of dentate granule cell synapses upon the pyramidal cell dendrites in mouse hippocampusJournal of Comparative Neurology, 156
S. Knafo, F. Libersat, E. Barkai (2005)
Olfactory learning‐induced morphological modifications in single dendritic spines of young ratsEuropean Journal of Neuroscience, 21
J. Dalley, R. Cardinal, T. Robbins (2004)
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substratesNeuroscience & Biobehavioral Reviews, 28
E. Glaser, H. Loos (1981)
Analysis of thick brain sections by obverse—Reverse computer microscopy: Application of a new, high clarity Golgi—Nissl stainJournal of Neuroscience Methods, 4
S. Middei, L. Restivo, C. Sgobio, Enrica Passino, M. Ammassari-Teule (2004)
Reversible inactivation of hippocampus and dorsolateral striatum in C57BL/6 and DBA/2 inbred mice failed to show interaction between memory systems in these genotypesBehavioural Brain Research, 154
B. Leuner, Jacqueline Falduto, T. Shors (2003)
Associative Memory Formation Increases the Observation of Dendritic Spines in the HippocampusThe Journal of Neuroscience, 23
A. Feria-Velasco, A. Angel, I. González-Burgos (2002)
Modification of dendritic development.Progress in brain research, 136
S. Knafo, F. Libersat, E. Barkai (2005)
Dynamics of learning‐induced spine redistribution along dendrites of pyramidal neurons in ratsEuropean Journal of Neuroscience, 21
Kolb Kolb, Whishaw Whishaw (1998)
Brain plasticity and behaviorAnnu Rev Psychol, 49
Enrica Passino, S. Middei, L. Restivo, V. Bertaina-Anglade, M. Ammassari-Teule (2002)
Genetic approach to variability of memory systems: Analysis of place vs. response learning and Fos‐related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 miceHippocampus, 12
L. Restivo, F. Ferrari, Enrica Passino, C. Sgobio, J. Bock, B. Oostra, C. Bagni, M. Ammassari-Teule (2005)
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.Proceedings of the National Academy of Sciences of the United States of America, 102 32
M. Eyre, G. Richter-Levin, A. Avital, M. Stewart (2003)
Morphological changes in hippocampal dentate gyrus synapses following spatial learning in rats are transientEuropean Journal of Neuroscience, 17
S. Matsuyama, U. Namgung, A. Routtenberg (1997)
Long-term potentiation persistence greater in C57BL/6 than DBA/2 mice: Predicted on basis of protein kinase C levels and learning performanceBrain Research, 763
M. Ammassari-Teule, Enrica Passino, L. Restivo, Benedetta Marsanich (2000)
Fear conditioning in C57/BL/6 and DBA/2 mice: variability in nucleus accumbens function according to the strain predisposition to show contextual‐ or cue‐based respondingEuropean Journal of Neuroscience, 12
T. Hosokawa, D. Rusakov, T. Bliss, Alan Fine, Monte Sim-Ulation (1995)
Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP, 15
J. Wehner, S. Sleight, M. Upchurch (1990)
Hippocampal protein kinase C activity is reduced in poor spatial learnersBrain Research, 523
M. Feldman, A. Peters (1979)
A technique for estimating total spine numbers on golgi‐impregnated dendritesJournal of Comparative Neurology, 188
C. Faherty, D. Kerley, Richard Smeyne (2003)
A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment.Brain research. Developmental brain research, 141 1-2
S. Mihalick, J. Langlois, J. Krienke (2000)
Strain and sex differences on olfactory discrimination learning in C57BL/6J and DBA/2J inbred mice (Mus musculus).Journal of comparative psychology, 114 4
R. Paylor, Ryan Tracy, J. Wehner, J. Rudy (1994)
DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning.Behavioral neuroscience, 108 4
N. Toni, Pierre-Alain Buchs, I. Nikonenko, C. Bron, D. Muller (1999)
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendriteNature, 402
N. Bannister, A. Larkman (1995)
Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: I. Branching patternsJournal of Comparative Neurology, 360
R. Gibb, B. Kolb (1998)
A method for vibratome sectioning of Golgi–Cox stained whole rat brainJournal of Neuroscience Methods, 79
M. Moser, M. Trommald, P. Andersen (1994)
An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses.Proceedings of the National Academy of Sciences of the United States of America, 91 26
U. Staubli, D. Fraser, R. Faraday, G. Lynch (1987)
Olfaction and the "data" memory system in rats.Behavioral neuroscience, 101 6
M. Moser, M. Trommald, T. Egeland, P. Andersen (1997)
Spatial training in a complex environment and isolation alter the spine distribution differently in rat CA1 pyramidal cells.The Journal of comparative neurology, 380 3
A. Holmes, C. Wrenn, Ashley Harris, K. Thayer, J. Crawley (2002)
Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in miceGenes, 1
C. O'Connell, A. O'Malley, C. Regan (1996)
Transient, learning-induced ultrastructural change in spatially-clustered dentate granule cells of the adult rat hippocampusNeuroscience, 76
A. O'Malley, C. O'Connell, K. Murphy, C. Regan (2000)
Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodentNeuroscience, 99
P. Nguyen, T. Abel, E. Kandel, Roussoudan Bourtchouladze (2000)
Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice.Learning & memory, 7 3
M. Ammassari-Teule, A. Caprioli (1985)
Spatial learning and memory, maze running strategies and cholinergic mechanisms in two inbred strains of miceBehavioural Brain Research, 17
Francois Roman, Evelyne Marchetti, Alain Bouquerel, B. Soumireu-Mourat, (2002)
The olfactory tubing maze: a new apparatus for studying learning and memory processes in miceJournal of Neuroscience Methods, 117
J. Dusek, H. Eichenbaum (1997)
The hippocampus and memory for orderly stimulus relations.Proceedings of the National Academy of Sciences of the United States of America, 94 13
P. Alvarez, H. Eichenbaum (2002)
Representations of odors in the rat orbitofrontal cortex change during and after learning.Behavioral neuroscience, 116 3
M. Ragozzino, S. Detrick, R. Kesner (1999)
Involvement of the Prelimbic–Infralimbic Areas of the Rodent Prefrontal Cortex in Behavioral Flexibility for Place and Response LearningThe Journal of Neuroscience, 19
M. Ragozzino (2002)
The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility.Learning & memory, 9 1
M. Ammassari-Teule, C. Castellano (2004)
Strains of Rodents and the Pharmacology of Learning and MemoryNeural Plasticity, 11
N. Otmakhov, J. Tao-Cheng, S. Carpenter, Brent Asrican, A. Dosemeci, T. Reese, J. Lisman (2004)
Persistent Accumulation of Calcium/Calmodulin-Dependent Protein Kinase II in Dendritic Spines after Induction of NMDA Receptor-Dependent Chemical Long-Term PotentiationThe Journal of Neuroscience, 24
C. Horner, E. Arbuthnott (1991)
Methods of estimation of spine density--are spines evenly distributed throughout the dendritic field?Journal of anatomy, 177
R. Paylor, Linda Baskall, J. Wehner (1993)
Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesisPsychobiology
Bliss Tv, T. Lømo (1970)
Plasticity in a monosynaptic cortical pathway.The Journal of physiology, 207 2
S. Knafo, G. Ariav, E. Barkai, F. Libersat (2004)
Olfactory learning‐induced increase in spine density along the apical dendrites of CA1 hippocampal neuronsHippocampus, 14
N. Bannister, A. Larkman (1995)
Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: II. Spine distributionsJournal of Comparative Neurology, 360
F. Chaillan, Evelyne Marchetti, B. Soumireu-Mourat,, Francois Roman (2005)
Selective impairment of subcategories of long-term memory in mice with hippocampal lesions accessed by the olfactory tubing mazeBehavioural Brain Research, 158
M. Trommald, G. Hulleberg, Per Andersen (1996)
Long-term potentiation is associated with new excitatory spine synapses on rat dentate granule cells.Learning & memory, 3 2-3
M. Bunsey, H. Eichenbaum (1996)
Conservation of hippocampal memory function in rats and humansNature, 379
D. Rusakov, Heather Davies, E. Harrison, G. Diana, G. Diana, Gal Richter-Levin, Gal Richter-Levin, T. Bliss, Michael Stewart (1997)
Ultrastructural synaptic correlates of spatial learning in rat hippocampusNeuroscience, 80
Y. Geinisman (2000)
Structural synaptic modifications associated with hippocampal LTP and behavioral learning.Cerebral cortex, 10 10
J. Bock, Katharina Braun (1999)
Blockade of N-methyl-D-aspartate receptor activation suppresses learning-induced synaptic elimination.Proceedings of the National Academy of Sciences of the United States of America, 96 5
D. Bovet, F. Bovet-Nitti, A. Oliverio (1969)
Genetic aspects of learning and memory in mice.Science, 163 3863
L. Restivo, Enrica Passino, S. Middei, M. Ammassari-Teule (2002)
The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA miceBrain Research Bulletin, 57
Wim Crusio, H. Schwegler, H. Lipp (1987)
Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distributionBrain Research, 425
A. Feria-Velasco, A. Angel, I. González-Burgos (2002)
Chapter 11 Modification of dendritic developmentProgress in Brain Research, 136
B. Kolb, R. Gibb, T. Robinson (2003)
Brain Plasticity and BehaviorCurrent Directions in Psychological Science, 12
M. Upchurch, J. Wehner (1989)
Inheritance of spatial learning ability in inbred mice: a classical genetic analysis.Behavioral neuroscience, 103 6
This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus‐related learning. The behavioral data first showed a clear‐cut difference in performance between the two strains. C57 mice learned to identify the positively reinforced olfactory cue whereas DBA did not. Both strains, however, similarly acquired the procedural aspects of the task. The morphological analysis performed 24 h post‐training revealed that spine density was significantly increased along apical, oblique, and basal dendrites in trained C57 mice compared to trained DBA mice, and to pseudotrained as well as to control cage mice of both strains. These findings confirm the ability of C57 mice to solve hippocampal‐dependent tasks and provide the first evidence that simultaneous olfactory discrimination learning elicits spine growth in the mouse hippocampus. In addition, the finding that DBA mice failed to discriminate between the two olfactory cues but were as efficient as C57 mice in learning the procedural aspects of the task outlines that the structural changes observed in the latter strain were independent from any procedural learning component. © 2006 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Jan 1, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.