Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Simultaneous olfactory discrimination elicits a strain‐specific increase in dendritic spines in the hippocampus of inbred mice

Simultaneous olfactory discrimination elicits a strain‐specific increase in dendritic spines in... This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus‐related learning. The behavioral data first showed a clear‐cut difference in performance between the two strains. C57 mice learned to identify the positively reinforced olfactory cue whereas DBA did not. Both strains, however, similarly acquired the procedural aspects of the task. The morphological analysis performed 24 h post‐training revealed that spine density was significantly increased along apical, oblique, and basal dendrites in trained C57 mice compared to trained DBA mice, and to pseudotrained as well as to control cage mice of both strains. These findings confirm the ability of C57 mice to solve hippocampal‐dependent tasks and provide the first evidence that simultaneous olfactory discrimination learning elicits spine growth in the mouse hippocampus. In addition, the finding that DBA mice failed to discriminate between the two olfactory cues but were as efficient as C57 mice in learning the procedural aspects of the task outlines that the structural changes observed in the latter strain were independent from any procedural learning component. © 2006 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Simultaneous olfactory discrimination elicits a strain‐specific increase in dendritic spines in the hippocampus of inbred mice

Loading next page...
 
/lp/wiley/simultaneous-olfactory-discrimination-elicits-a-strain-specific-n5W4JPGXjI

References (57)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley‐Liss, Inc.
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20174
pmid
16502390
Publisher site
See Article on Publisher Site

Abstract

This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus‐related learning. The behavioral data first showed a clear‐cut difference in performance between the two strains. C57 mice learned to identify the positively reinforced olfactory cue whereas DBA did not. Both strains, however, similarly acquired the procedural aspects of the task. The morphological analysis performed 24 h post‐training revealed that spine density was significantly increased along apical, oblique, and basal dendrites in trained C57 mice compared to trained DBA mice, and to pseudotrained as well as to control cage mice of both strains. These findings confirm the ability of C57 mice to solve hippocampal‐dependent tasks and provide the first evidence that simultaneous olfactory discrimination learning elicits spine growth in the mouse hippocampus. In addition, the finding that DBA mice failed to discriminate between the two olfactory cues but were as efficient as C57 mice in learning the procedural aspects of the task outlines that the structural changes observed in the latter strain were independent from any procedural learning component. © 2006 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 2006

There are no references for this article.