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- Publisher
- Wiley
- Copyright
- Copyright © 2018 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd
- ISSN
- 2049-4173
- eISSN
- 2049-4173
- DOI
- 10.1111/ncn3.12225
- Publisher site
- See Article on Publisher Site
Abstract
Given the slow‐colonic transit, typical dosing schedule (bedtime administration) of laxative may be unreasonable for treating Parkinson's disease (PD)‐related constipation, that is, to have morning defecations, bedtime administration might be too late for the drug to reach the large intestine during sleep (high colonic motility due to parasympathetic dominance). Shifting laxative dosing schedule to earlier times may help the drug to reach the large intestine during sleep. Here, we reported 21 PD patients with refractory constipation, whose bowel movements were significantly improved, and PD‐related symptoms (such as wearing off and hallucinations) were substantially improved after the shift of laxatives dosing schedule to an earlier time. Because of the simplicity and effectiveness, this strategy might be widely used in treating PD‐related constipation. This retrospective observational case series study was, however, limited in the uncontrolled study design, small sample size, and subjective data sources. A randomized, placebo‐controlled trial is warranted to confirm our results.
Journal
Neurology and Clinical Neuroscience – Wiley
Published: Nov 1, 2018
Keywords: ; ; ; ;