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Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study

Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study To cite this article: van Oeffelen AAM, Bekkers MBM, Smit HA, Kerkhof M, Koppelman GH, Haveman‐Nies A, van der A DL, Jansen EHJM, Wijga AH. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011: 22: 784–793. Background: Research suggests an influence of micronutrients on childhood asthma. So far, evidence mainly originates from cross‐sectional studies using nutrient intake data, which is not an accurate measure of nutrient status. This study aimed to investigate the cross‐sectional and prospective associations between serum concentrations of magnesium, vitamin D, selenium, and zinc and prevalence of (severe) asthma, atopy, and bronchial hyperresponsiveness (BHR) in childhood. Methods: In the Prevention and Incidence of Asthma and Mite Allergy birth cohort study, serum nutrient concentrations were available for a 4‐yr‐old subgroup (n = 372) and for a different 8‐yr‐old subgroup (n = 328). Yearly questionnaires inquired about asthma prevalence until 8 yr of age. Allergic sensitization was measured at 4 and 8 yr of age; BHR was measured at 8 yr of age. Data were analyzed with logistic regression and generalized estimating equations models. Results: There was a consistent (non‐significant) inverse association between serum magnesium concentrations and asthma prevalence. Serum vitamin D concentrations measured at age 4 were inversely associated with asthma at ages 4–8 (e.g., cross‐sectional association between vitamin D tertile 3 vs. 1 and severe asthma: odds ratio (OR): 0.49, 95% confidence interval (CI): 0.25–0.95), whereas vitamin D measured at age 8 was positively associated with asthma at age 8 (e.g., cross‐sectional association between vitamin D tertile 3 vs. 1 and severe asthma: OR: 2.14, 95% CI: 0.67–6.82). Conclusions: Our study contributes to the evidence that children with higher serum magnesium concentrations are less likely to have asthma. The associations between serum vitamin D concentrations and asthma were age‐dependent. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study

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References (59)

Publisher
Wiley
Copyright
Copyright © 2011 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.2011.01190.x
pmid
21929603
Publisher site
See Article on Publisher Site

Abstract

To cite this article: van Oeffelen AAM, Bekkers MBM, Smit HA, Kerkhof M, Koppelman GH, Haveman‐Nies A, van der A DL, Jansen EHJM, Wijga AH. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011: 22: 784–793. Background: Research suggests an influence of micronutrients on childhood asthma. So far, evidence mainly originates from cross‐sectional studies using nutrient intake data, which is not an accurate measure of nutrient status. This study aimed to investigate the cross‐sectional and prospective associations between serum concentrations of magnesium, vitamin D, selenium, and zinc and prevalence of (severe) asthma, atopy, and bronchial hyperresponsiveness (BHR) in childhood. Methods: In the Prevention and Incidence of Asthma and Mite Allergy birth cohort study, serum nutrient concentrations were available for a 4‐yr‐old subgroup (n = 372) and for a different 8‐yr‐old subgroup (n = 328). Yearly questionnaires inquired about asthma prevalence until 8 yr of age. Allergic sensitization was measured at 4 and 8 yr of age; BHR was measured at 8 yr of age. Data were analyzed with logistic regression and generalized estimating equations models. Results: There was a consistent (non‐significant) inverse association between serum magnesium concentrations and asthma prevalence. Serum vitamin D concentrations measured at age 4 were inversely associated with asthma at ages 4–8 (e.g., cross‐sectional association between vitamin D tertile 3 vs. 1 and severe asthma: odds ratio (OR): 0.49, 95% confidence interval (CI): 0.25–0.95), whereas vitamin D measured at age 8 was positively associated with asthma at age 8 (e.g., cross‐sectional association between vitamin D tertile 3 vs. 1 and severe asthma: OR: 2.14, 95% CI: 0.67–6.82). Conclusions: Our study contributes to the evidence that children with higher serum magnesium concentrations are less likely to have asthma. The associations between serum vitamin D concentrations and asthma were age‐dependent.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Dec 1, 2011

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