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Serum gamma globulin groups in Japanese

Serum gamma globulin groups in Japanese Summary Serum gamma globulin (Gm) groups were determined for 262 Japanese. The resulting allele frequency estimate for Gma was 0–885 and for Gmb 0–115. Some reservation is necessary in accepting these estimates at face value because of failure to observe any Gm(a ‐ b +) individual. There was no significant difference in the Gma and Gmb frequencies between normal Japanese subjects and Japanese with rheumatoid arthritis. An attempt was made to detect new Gm factors in the American population by the use of sera from Japanese rheumatoid arthritis. The attempt was based on the assumptions that effective typing sera from rheumatoid arthritics must lack the Gm factor sought, that such typing sera must be very rare in populations where the Gm factor in question is common, and that ethnic differences in Gm allele frequencies extend to undetected alleles. The attempt failed; however, the method of approach may be of value to future investigators. We wish to offer our thanks for the provision of sera from American‐born Japanese children to Dr Stanley Wright, University of California at Los Angeles, School of Medicine. This investigation was supported in part by Grant no. B2053 from the National Heart Institute, the National Institutes of Health, Bethesda, Maryland. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Serum gamma globulin groups in Japanese

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References (25)

Publisher
Wiley
Copyright
Copyright © 1961 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1961.tb01499.x
Publisher site
See Article on Publisher Site

Abstract

Summary Serum gamma globulin (Gm) groups were determined for 262 Japanese. The resulting allele frequency estimate for Gma was 0–885 and for Gmb 0–115. Some reservation is necessary in accepting these estimates at face value because of failure to observe any Gm(a ‐ b +) individual. There was no significant difference in the Gma and Gmb frequencies between normal Japanese subjects and Japanese with rheumatoid arthritis. An attempt was made to detect new Gm factors in the American population by the use of sera from Japanese rheumatoid arthritis. The attempt was based on the assumptions that effective typing sera from rheumatoid arthritics must lack the Gm factor sought, that such typing sera must be very rare in populations where the Gm factor in question is common, and that ethnic differences in Gm allele frequencies extend to undetected alleles. The attempt failed; however, the method of approach may be of value to future investigators. We wish to offer our thanks for the provision of sera from American‐born Japanese children to Dr Stanley Wright, University of California at Los Angeles, School of Medicine. This investigation was supported in part by Grant no. B2053 from the National Heart Institute, the National Institutes of Health, Bethesda, Maryland.

Journal

Annals of Human GeneticsWiley

Published: Sep 1, 1961

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