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ISSN 0906-3784 Sensitization and development of tolerance via the gut Hanson LA, Telemo E, Wiedermann U, Dahlman A, Saalman R, Ahlstedt S, Friman V, Holmgren J, Czerkinsky C, Dahlgren U. Sensitization and development of tolerance via the gut. Pediatr Allergy Immunol 1993: 4 (Suppl 3): 16-20. 0Munksgaard 1993. L. A. Hansonâ, E. Telemoâ, U. Wiedermannâ, A. Dahlrnanâ, R. Saalmad, S. Ahlstedtâ, V. himan*, J. Holrngren3,C. Czerkinsky3, U. Dahlgrenâ Departments of âClinical Immunology, âMedical Microbiology and Immunology and 31nfectious Diseases, University of Goteborg, Sweden Lars 8. Hanson, Department of Clinical Immunology, Guldhedsgatan 10, S-413 46 Goteborg, Sweden Key words: sensitization; tolerance; gut Background and history As an immunological organ, the gut has an almost impossible task. It must be able to defend its vast surfaces of mucosal membranes from exposure to pathogenic microorganisms. At the same time, it has to accept without reactivity the normal intestinal flora and foreign material in the form of food. The fact that the gut is such a major lymphoid organ (Scott et al., this publication) illustrates the importance of the defence of the intestinal mucosal surfaces. The predominance of the secretory IgA (SIgA) system and the great number of T-lymphocytes in the epithelium
Pediatric Allergy and Immunology – Wiley
Published: Jun 1, 1993
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