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Sensitive methods and improved screening strategies are needed for the detection of pig viruses

Sensitive methods and improved screening strategies are needed for the detection of pig viruses To the Editor:Xenotransplantation using pig cells, tissues or organs may be associated with the transmission of porcine microorganisms, including viruses, to the recipient. At the moment, it is still unclear which porcine microorganisms may infect humans and which are able to induce zoonoses. Hepatitis E virus (HEV), for example, is a porcine virus with known zoonotic transmission. HEV is transmitted by undercooked pig meat or contact to pigs and induces diseases in patients with an underlying liver disease and in immunocompromised patients, but infections of healthy individuals are asymptomatic (for review see).Here, I will concentrate on the porcine cytomegalovirus (PCMV), which is the first porcine virus found transmitted to non‐human primates after transplantation of pig organs. In all reported cases, PCMV was detected in the transplant recipients; however, it remains unclear whether the virus infected the non‐human primates or was replicating only in the transplants. When transplanting kidneys from PCMV‐positive pigs into baboons, a transplant dysfunction was observed and the survival time was reduced to 14.1 days (average of 10 animals) compared with 48.3 days (eight animals) when using kidneys from PCMV‐negative pigs. A similar observation was made when kidneys were transplanted into cynomolgus monkeys (28.7, three animals, compared with 9.2 days, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Sensitive methods and improved screening strategies are needed for the detection of pig viruses

Denner, Joachim
Xenotransplantation , Volume 24 (3) – May 1, 2017
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References (23)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12303
pmid
28432699
Publisher site
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Abstract

To the Editor:Xenotransplantation using pig cells, tissues or organs may be associated with the transmission of porcine microorganisms, including viruses, to the recipient. At the moment, it is still unclear which porcine microorganisms may infect humans and which are able to induce zoonoses. Hepatitis E virus (HEV), for example, is a porcine virus with known zoonotic transmission. HEV is transmitted by undercooked pig meat or contact to pigs and induces diseases in patients with an underlying liver disease and in immunocompromised patients, but infections of healthy individuals are asymptomatic (for review see).Here, I will concentrate on the porcine cytomegalovirus (PCMV), which is the first porcine virus found transmitted to non‐human primates after transplantation of pig organs. In all reported cases, PCMV was detected in the transplant recipients; however, it remains unclear whether the virus infected the non‐human primates or was replicating only in the transplants. When transplanting kidneys from PCMV‐positive pigs into baboons, a transplant dysfunction was observed and the survival time was reduced to 14.1 days (average of 10 animals) compared with 48.3 days (eight animals) when using kidneys from PCMV‐negative pigs. A similar observation was made when kidneys were transplanted into cynomolgus monkeys (28.7, three animals, compared with 9.2 days,

Journal

Xenotransplantation – Wiley

Published: May 1, 2017

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