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Segregation of ACP 1 and MNSs in families with structural rearrangements involving chromosome 2

Segregation of ACP 1 and MNSs in families with structural rearrangements involving chromosome 2 Segregation of ACP, and MNSs in families with structural rearrangements involving chromosome 2 BY M. A. MACE,* J. NOADES, E. B. ROBSON MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London M . HULTfiN, J. LINDSTEN Department of Clinical Genetics, Karolinska Hospital, Stockholm P. E. POLANI Paediatric Research Unit, Guy’s Hospital Medical School, London P. A. JACOBS AND K. E. BUCKTON MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh In 1968 the MNSs blood group locus was assigned to the long arm of either chromosome 2 or 4 by the method of deletion mapping (German et al. 1968, 1969). This work was reassessed when the development of the new banding techniques made it possible to determine the breakpoints, and MNSs assigned specifically to band 2q14 (German & Chaganti, 1973). ACP,, the locus for red cell acid phosphatase, has also been implicated with chromosome 2 (Weitkamp et al. 1969). ACP, has now been assigned to that chromosome by work on somatic cell hybrids (Povey et al. 1974), having previously been assigned to the specific region p23-tpter by deletion mapping (Ferguson-Smith et al. 1973), and recently provisionally assigned to band p23 itself (Hamerton et al. 1975). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Segregation of ACP 1 and MNSs in families with structural rearrangements involving chromosome 2

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References (24)

Publisher
Wiley
Copyright
Copyright © 1975 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1975.tb00637.x
Publisher site
See Article on Publisher Site

Abstract

Segregation of ACP, and MNSs in families with structural rearrangements involving chromosome 2 BY M. A. MACE,* J. NOADES, E. B. ROBSON MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London M . HULTfiN, J. LINDSTEN Department of Clinical Genetics, Karolinska Hospital, Stockholm P. E. POLANI Paediatric Research Unit, Guy’s Hospital Medical School, London P. A. JACOBS AND K. E. BUCKTON MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh In 1968 the MNSs blood group locus was assigned to the long arm of either chromosome 2 or 4 by the method of deletion mapping (German et al. 1968, 1969). This work was reassessed when the development of the new banding techniques made it possible to determine the breakpoints, and MNSs assigned specifically to band 2q14 (German & Chaganti, 1973). ACP,, the locus for red cell acid phosphatase, has also been implicated with chromosome 2 (Weitkamp et al. 1969). ACP, has now been assigned to that chromosome by work on somatic cell hybrids (Povey et al. 1974), having previously been assigned to the specific region p23-tpter by deletion mapping (Ferguson-Smith et al. 1973), and recently provisionally assigned to band p23 itself (Hamerton et al. 1975).

Journal

Annals of Human GeneticsWiley

Published: May 1, 1975

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