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The group of Dr Denner at the Robert Koch Institute, Berlin‐FRG, reports in this issue of xenotransplantation on the presence of porcine endogenous retroviruses (PERVs) in the herd of Göttingen minipigs held at Ellegaard, Denmark . In a series of 15 animals all three subtypes, PERV‐A, PERV‐B and PERV‐C, were detected and also a new variant of PERV‐C that was recently described by the same group . The expression of PERV was higher than in other pig breeds analyzed by the same group and reported earlier elsewhere . This included German Landrace, Schwäbisch‐Hall, and Duroc/GL breeds: A small number of Large White pigs showed similar or even higher expression. Finally, blood mononuclear cells from five animals were stimulated with the mitogen phytohaemagglutinin and assessed for transmission of PERV into human embryonic kidney 293 cells, either by adding the supernatant of stimulated porcine cells to the human target cells or by coculture with separation of the two cell populations by a 0.4‐μm pore size membrane. In this in vitro transmission assay there was no PERV transmission detected. This manuscript is relevant for the discussion on safety of a xenotransplantation product for a number of aspects. The report is the
Xenotransplantation – Wiley
Published: May 1, 2013
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