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Scientific Summaries for Families with ASD

Scientific Summaries for Families with ASD Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies Michael W. Nestor, Andre W. Phillips, Elena Artimovich, Jonathan E. Nestor, John P. Hussman, and Gene J. Blatt Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental condition. Symptoms of ASD cover the spectrum from mild qualitative differences in social interaction to severe communication and social and behav- ioral challenges that require lifelong support. Attempts at understanding the pathophysiology of ASD have been hampered by a multifactorial etiology that stretches the limits of current behavioral and cell based models. Recent progress has implicated numerous autism-risk genes but efforts to gain a better understanding of the underlying biological mechanisms have seen slow progress. This is in part due to lack of appropriate models for complete molecular and pharmacological studies. The advent of induced pluripotent stem cells (iPSC) has reinvigorated efforts to establish more complete model systems that more reliably identify molecular pathways and predict effec- tive drug targets and candidates in ASD. iPSCs are particularly appealing because they can be derived from human patients and controls for research purposes and provide a technology for the development of a personalized treat- ment regimen for ASD patients. The pluripotency of iPSCs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

Scientific Summaries for Families with ASD

Autism Research , Volume 9 (5) – May 1, 2016
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Publisher
Wiley
Copyright
© 2016 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1648
Publisher site
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Abstract

Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies Michael W. Nestor, Andre W. Phillips, Elena Artimovich, Jonathan E. Nestor, John P. Hussman, and Gene J. Blatt Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental condition. Symptoms of ASD cover the spectrum from mild qualitative differences in social interaction to severe communication and social and behav- ioral challenges that require lifelong support. Attempts at understanding the pathophysiology of ASD have been hampered by a multifactorial etiology that stretches the limits of current behavioral and cell based models. Recent progress has implicated numerous autism-risk genes but efforts to gain a better understanding of the underlying biological mechanisms have seen slow progress. This is in part due to lack of appropriate models for complete molecular and pharmacological studies. The advent of induced pluripotent stem cells (iPSC) has reinvigorated efforts to establish more complete model systems that more reliably identify molecular pathways and predict effec- tive drug targets and candidates in ASD. iPSCs are particularly appealing because they can be derived from human patients and controls for research purposes and provide a technology for the development of a personalized treat- ment regimen for ASD patients. The pluripotency of iPSCs

Journal

Autism Research – Wiley

Published: May 1, 2016

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