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Commentary – Autism Spectrum Disorder: Spectrum or Cluster? John R. Pruett, Jr. and Daniel J. Povinelli Article citation: Autism Res 2016, 9: 1237–1240. DOI: 10.1002/aur.1650 Elevated Levels of Tissue Plasminogen Activator and E-Selectin in Male Children With Autism Spectrum Disorder S ¸eref S ¸ims ¸ek, Ihsan C ¸etin, Abdullah C ¸im, and Savas ¸ Kaya Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plas- minogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previ- ously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P5 0.025) and E-selectin (P5 0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative corre- lation with sensory, body and object-use,
Autism Research – Wiley
Published: Dec 1, 2016
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