Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Larsen, S. Knechtle, A. Adams, T. Pearson, A. Kirk (2006)
A New Look at Blockade of T‐cell Costimulation: A Therapeutic Strategy for Long‐term Maintenance ImmunosuppressionAmerican Journal of Transplantation, 6
P. Thompson, I. Badell, M. Lowe, JA Cano, Mingqing Song, F. Leopardi, J. Avila, R. Ruhil, E. Strobert, G. Korbutt, G. Rayat, Rajotte Rv, N. Iwakoshi, C. Larsen, A. Kirk (2011)
Islet Xenotransplantation Using Gal‐Deficient Neonatal Donors Improves Engraftment and FunctionAmerican Journal of Transplantation, 11
L. Buhler, I. Alwayn, J. Appel, S. Robson, D. Cooper (2001)
Anti-CD154 monoclonal antibody and thromboembolism.Transplantation, 71 3
M. Mohiuddin, Avneesh Singh, P. Corcoran, R. Hoyt, Marvin Thomas, B. Lewis, M. Eckhaus, Nicole Dabkowski, Aaron Belli, K. Reimann, D. Ayares, K. Horvath (2014)
Role of anti‐CD40 antibody‐mediated costimulation blockade on non‐Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig‐to‐baboon modelXenotransplantation, 21
J. Shin, Jong Kim, J. Kim, Byoung-Hoon Min, Yong-Hee Kim, Hee Kim, Jae-Yool Jang, Il‐Hee Yoon, H. Kang, Jung Kim, E. Hwang, D. Lim, Won-Woo Lee, J. Ha, Kunhwa Jung, Si Park, S. Kim, Chung-Gyu Park (2015)
Long‐Term Control of Diabetes in Immunosuppressed Nonhuman Primates (NHP) by the Transplantation of Adult Porcine IsletsAmerican Journal of Transplantation, 15
Chung-Gyu Park, R. Bottino, W. Hawthorne (2015)
Current status of islet xenotransplantation.International journal of surgery, 23 Pt B
Jenny Xie, A. Yamniuk, Virna Borowski, R. Kuhn, Vojkan Susulic, Sandra Rex-Rabe, Xiaoxia Yang, Xiadi Zhou, Yifan Zhang, Kathleen Gillooly, R. Brosius, R. Ravishankar, K. Waggie, K. Mink, L. Price, R. Rehfuss, J. Tamura, Yongmi An, Lin Cheng, Bozena Abramczyk, O. Ignatovich, P. Drew, S. Grant, J. Bryson, S. Suchard, L. Salter-Cid, S. Nadler, A. Suri (2014)
Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune DiseasesThe Journal of Immunology, 192
H. Iwase, B. Ekser, H. Hara, C. Phelps, D. Ayares, D. Cooper, M. Ezzelarab (2014)
Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibitionXenotransplantation, 21
C. Knosalla, B. Gollackner, D. Cooper (2002)
Anti-CD154 monoclonal antibody and thromboembolism revisted.Transplantation, 74 3
A. Kirk, A. Kirk, A. Kirk, L. Burkly, D. Batty, R. Baumgartner, J. Berning, K. Buchanan, J. Fechner, Rhonda Germond, R. Kampen, N. Patterson, S. Swanson, D. Tadaki, C. Tenhoor, Leonard White, S. Knechtle, D. Harlan (1999)
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primatesNature Medicine, 5
R. Bottino, M. Wijkstrom, D. Windt, H. Hara, M. Ezzelarab, N. Murase, S. Bertera, Jing He, C. Phelps, D. Ayares, D. Cooper, M. Trucco (2014)
Pig‐to‐Monkey Islet Xenotransplantation Using Multi‐Transgenic PigsAmerican Journal of Transplantation, 14
P. Andre, K. Prasad, Cécile Denis, Ming He, Jessie Papalia, Richard Hynes, David Phillips, Denisa Wagner (2002)
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanismNature Medicine, 8
A. Kirk, D. Harlan, N. Armstrong, T. Davis, Yinchen Dong, G. Gray, X. Hong, David Thomas, J. Fechner, S. Knechtle (1997)
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.Proceedings of the National Academy of Sciences of the United States of America, 94 16
R. Armitage, W. Fanslow, L. Strockbine, Timothy Sato, K. Clifford, B. Macduff, Dirk Anderson, S. Gimpel, T. Davis‐Smith, C. Maliszewski, E. Clark, Craig Smith, K. Grabstein, D. Cosman, M. Spriggs (1992)
Molecular and biological characterization of a murine ligand for CD40Nature, 357
K. Kalunian, John Davis, J. Merrill, M. Totoritis, D. Wofsy (2002)
Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial.Arthritis and rheumatism, 46 12
M. Ezzelarab, B. Ekser, G. Echeverri, H. Hara, Corin Ezzelarab, Cassandra Long, P. Bajona, B. Garcia, N. Murase, D. Ayares, D. Cooper (2012)
Costimulation blockade in pig artery patch xenotransplantation – a simple model to monitor the adaptive immune response in nonhuman primatesXenotransplantation, 19
K. Cardona, G. Korbutt, Z. Milas, J. Lyon, J. Cano, Wan-lin Jiang, Hameeda Bello-Laborn, Brad Hacquoil, E. Strobert, Shivaprakash Gangappa, C. Weber, T. Pearson, R. Rajotte, C. Larsen (2006)
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathwaysNature Medicine, 12
D. Cooper, V. Satyananda, B. Ekser, D. Windt, H. Hara, M. Ezzelarab, H. Schuurman (2014)
Progress in pig‐to‐non‐human primate transplantation models (1998–2013): a comprehensive review of the literatureXenotransplantation, 21
A. Peters, L. Stunz, G. Bishop (2009)
CD40 and autoimmunity: the dark side of a great activator.Seminars in immunology, 21 5
B. Hering, M. Wijkstrom, M. Graham, M. Hårdstedt, T. Aasheim, T. Jie, J. Ansite, M. Nakano, Jane Cheng, Wei Li, K. Moran, U. Christians, Colleen Finnegan, C. Mills, D. Sutherland, P. Bansal‐Pakala, M. Murtaugh, N. Kirchhof, H. Schuurman (2006)
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primatesNature Medicine, 12
L. Bühler, M. Awwad, M. Basker, S. Gojo, Anthony Watts, S. Treter, K. Nash, G. Oravec, Q. Chang, A. Thall, J. Down, Megan Sykes, D. Andrews, Robert Sackstein, M. White-Scharf, D. Sachs, D. Cooper (2000)
High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.Transplantation, 69 11
N. Kenyon, M. Chatzipetrou, M. Masetti, A. Ranuncoli, Maria Oliveira, Joseph Wagner, A. Kirk, D. Harlan, L. Burkly, C. Ricordi (1999)
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.Proceedings of the National Academy of Sciences of the United States of America, 96 14
I. Koyama, T. Kawai, D. Andrews, S. Boskovic, O. Nadazdin, S. Wee, H. Sogawa, Dongni Wu, R. Smith, R. Colvin, D. Sachs, A. Cosimi (2004)
Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates1Transplantation, 77
T. Kawai, D. Andrews, R. Colvin, D. Sachs, Cosimi Ab (2000)
Thromboembolic complications after treatment with monoclonal antibody against CD40 ligandNature Medicine, 6
H. Iwase, Hong Liu, M. Wijkstrom, Huidong Zhou, Jagjit Singh, H. Hara, M. Ezzelarab, Cassandra Long, E. Klein, R. Wagner, C. Phelps, D. Ayares, R. Shapiro, A. Humar, D. Cooper (2015)
Pig kidney graft survival in a baboon for 136 days: longest life‐supporting organ graft survival to dateXenotransplantation, 22
H. Tai, N. Campanile, M. Ezzelarab, D. Cooper, C. Phelps (2006)
Measurement of anti‐CD154 monoclonal antibody in primate sera by competitive inhibition ELISAXenotransplantation, 13
D. Windt, D. Windt, R. Bottino, Anna Casu, N. Campanile, C. Smetanka, Jing He, N. Murase, H. Hara, S. Ball, B. Loveland, D. Ayares, F. Lakkis, D. Cooper, M. Trucco (2009)
Long‐Term Controlled Normoglycemia in Diabetic Non‐Human Primates After Transplantation with hCD46 Transgenic Porcine IsletsAmerican Journal of Transplantation, 9
Wayne Hawthorne, E. Salvaris, P. Phillips, J. Hawkes, D. Liuwantara, Heather Burns, H. Barlow, A. Stewart, S. Peirce, Min Hu, Andrew Lew, Simon Robson, M. Nottle, A. D'apice, P. O’Connell, P. Cowan (2014)
Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in BaboonsAmerican Journal of Transplantation, 14
(2004)
Efficacy and safety of ABI793, a novel human anti human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation
L. Robles-Carrillo, T. Meyer, Meghan Hatfield, Hina Desai, Mónica Dávila, F. Langer, M. Amaya, E. Garber, J. Francis, Y. Hsu, A. Amirkhosravi (2010)
Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic MiceThe Journal of Immunology, 185
G. Roth, A. Zuckermann, W. Klepetko, E. Wolner, H. Ankersmit, B. Moser, I. Volf (2004)
Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates.Transplantation, 78 8
M. Baas, V. Gerdes, I. Berge, K. Heutinck, S. Florquin, J. Meijers, F. Bemelman (2013)
Treatment with everolimus is associated with a procoagulant state.Thrombosis research, 132 2
D. Boumpas, R. Furie, S. Manzi, G. Illei, D. Wallace, J. Balow, A. Vaishnaw (2003)
A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis.Arthritis and rheumatism, 48 3
M. Ezzelarab, B. Ekser, K. Isse, H. Iwase, A. Morelli, D. Ayares, D. Cooper (2014)
Increased Soluble CD154 (CD40 Ligand) Levels in Xenograft Recipients Correlate With the Development of De Novo Anti-Pig IgG AntibodiesTransplantation, 97
L. Bühler, S. Deng, J. O'neil, H. Kitamura, M. Koulmanda, A. Baldi, J. Rahier, I. Alwayn, J. Appel, M. Awwad, D. Sachs, G. Weir, J. Squifflet, D. Cooper, P. Morel (2002)
Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non‐myeloablative regimen and CD154 blockadeXenotransplantation, 9
V. Henn, J. Slupsky, M. Gräfe, I. Anagnostopoulos, R. Förster, G. Müller‐Berghaus, R. Kroczek (1998)
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cellsNature, 391
M. Levisetti, P. Padrid, G. Szot, Naveen Mittal, Shone Meehan, C. Wardrip, G. Gray, D. Bruce, J. Thistlethwaite, J. Bluestone (1997)
Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.Journal of immunology, 159 11
Anti‐CD154mAb is a powerful co‐stimulation blockade agent that is efficacious in preventing rejection, even in xenogeneic settings. It has been used in the majority of successful long‐term pig‐to‐non‐human primate islet transplantation models. However, its clinical use was halted as a result of thromboembolic complications that were also observed in preclinical and clinical organ transplantation models. An anti‐CD154mAb was administered to 14 streptozotocin‐induced diabetic cynomolgus monkey recipients of porcine islets, some of which received the agent for many months. Monkeys were monitored for complications, and blood monitoring was carried out frequently. After euthanasia, multiple biopsies of all organs were examined for histological features of thromboembolism. Anti‐CD154mAb prevented rejection of genetically engineered pig islets in all monkeys. No significant complications were attributable specifically to anti‐CD154mAb. There was no evidence of thromboembolism in multiple histological sections from all major organs, including the brain. Our data suggest that in diabetic monkeys with pig islet grafts, anti‐CD154mAb would appear to be an effective and safe therapy, and is not associated with thromboembolic complications.
Xenotransplantation – Wiley
Published: Jan 1, 2017
Keywords: ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.