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Review Article: CD47 in xenograft rejection and tolerance induction

Review Article: CD47 in xenograft rejection and tolerance induction Yang Y‐G. CD47 in xenograft rejection and tolerance induction. Xenotransplantation 2010; 17: 267–273. © 2010 John Wiley & Sons A/S. Abstract: Robust immune responses to xenografts remain a major obstacle to clinical translation of xenotransplantation, which could otherwise be a potential solution to the worldwide shortage of organ donors. The more vigorous xenograft rejection relative to allograft rejection is largely accounted for by the extensive genetic disparities between the donor and recipient. Xenografts activate host immunity not only by expressing immunogenic xenoantigens that provide the targets for immune recognition and rejection, but also by lacking ligands for the host immune inhibitory receptors. This review is focused on recent findings regarding the role of CD47, a ligand of an immune inhibitory receptor SIRPα, in xenograft rejection and induction of xenotolerance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Review Article: CD47 in xenograft rejection and tolerance induction

Xenotransplantation , Volume 17 (4) – Jul 1, 2010

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References (89)

Publisher
Wiley
Copyright
© 2010 John Wiley & Sons A/S
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/j.1399-3089.2010.00601.x
pmid
20723199
Publisher site
See Article on Publisher Site

Abstract

Yang Y‐G. CD47 in xenograft rejection and tolerance induction. Xenotransplantation 2010; 17: 267–273. © 2010 John Wiley & Sons A/S. Abstract: Robust immune responses to xenografts remain a major obstacle to clinical translation of xenotransplantation, which could otherwise be a potential solution to the worldwide shortage of organ donors. The more vigorous xenograft rejection relative to allograft rejection is largely accounted for by the extensive genetic disparities between the donor and recipient. Xenografts activate host immunity not only by expressing immunogenic xenoantigens that provide the targets for immune recognition and rejection, but also by lacking ligands for the host immune inhibitory receptors. This review is focused on recent findings regarding the role of CD47, a ligand of an immune inhibitory receptor SIRPα, in xenograft rejection and induction of xenotolerance.

Journal

XenotransplantationWiley

Published: Jul 1, 2010

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