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A. Dosanjh (2021)
Review for "Respiratory syncytial virus and airway microbiota – A complex interplay and its reflection on morbidity"Applied Immunohistochemistry & Molecular Morphology
N. Vissing, B. Chawes, H. Bisgaard (2013)
Increased risk of pneumonia and bronchiolitis after bacterial colonization of the airways as neonates.American journal of respiratory and critical care medicine, 188 10
Wouter Piters, Santtu Heinonen, R. Hasrat, Eleonora Bunsow, Bennett Smith, M. Suárez-Arrabal, D. Chaussabel, D. Cohen, E. Sanders, O. Ramilo, D. Bogaert, A. Mejías (2016)
Nasopharyngeal Microbiota, Host Transcriptome, and Disease Severity in Children with Respiratory Syncytial Virus Infection.American journal of respiratory and critical care medicine, 194 9
J. García-Rodríguez, M. Martínez (2002)
Dynamics of nasopharyngeal colonization by potential respiratory pathogens.The Journal of antimicrobial chemotherapy, 50 Suppl S2
V. Avadhanula, Yan Wang, A. Portner, E. Adderson (2006)
Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein.Journal of medical microbiology, 56 Pt 9
A. Auais, B. Adkins, G. Napchan, G. Piedimonte (2003)
Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats.American journal of physiology. Lung cellular and molecular physiology, 285 1
G. Biesbroek, Evgeni Tsivtsivadze, E. Sanders, R. Montijn, R. Veenhoven, B. Keijser, D. Bogaert (2014)
Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children.American journal of respiratory and critical care medicine, 190 11
E. Leibovitz, S. Raiz, L. Piglansky, D. Greenberg, P. Yagupsky, D. Fliss, A. Leiberman, R. Dagan (1998)
Resistance pattern of middle ear fluid isolates in acute otitis media recently treated with antibiotics.The Pediatric infectious disease journal, 17 6
G. Dubourg, S. Edouard, D. Raoult (2019)
Relationship between nasopharyngeal microbiota and patient’s susceptibility to viral infectionExpert Review of Anti-infective Therapy, 17
H. Faden, L. Duffy, R. Wasielewski, J. Wolf, D. Krystofik, Y. Tung (1997)
Relationship between nasopharyngeal colonization and the development of otitis media in children. Tonawanda/Williamsville Pediatrics.The Journal of infectious diseases, 175 6
T. Ederveen, G. Ferwerda, I. Ahout, M. Vissers, R. Groot, J. Boekhorst, H. Timmerman, M. Huynen, S. Hijum, M. Jonge (2018)
Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responsesMicrobiome, 6
G. Rossi, A. Colin (2017)
Respiratory syncytial virus–Host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later lifePediatric Allergy and Immunology, 28
C. Smith, Sara Sandrini, S. Datta, P. Freestone, Sulman Shafeeq, P. Radhakrishnan, Gwyneth Williams, Sarah Glenn, O. Kuipers, R. Hirst, A. Easton, P. Andrew, C. O’Callaghan (2014)
Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection.American journal of respiratory and critical care medicine, 190 2
Hong Guo-Parke, P. Canning, Isobel Douglas, Remi Villenave, L. Heaney, P. Coyle, J. Lyons, M. Shields, U. Power (2013)
Relative respiratory syncytial virus cytopathogenesis in upper and lower respiratory tract epithelium.American journal of respiratory and critical care medicine, 188 7
M. Rose, Franziska Stieglitz, A. Köksal, R. Schubert, J. Schulze, S. Zielen (2010)
Efficacy of probiotic Lactobacillus GG on allergic sensitization and asthma in infants at riskClinical & Experimental Allergy, 40
S. Teo, D. Mok, K. Pham, M. Kusel, M. Serralha, N. Troy, B. Holt, B. Hales, Michael Walker, E. Hollams, Y. Bochkov, K. Grindle, S. Johnston, J. Gern, P. Sly, P. Holt, K. Holt, M. Inouye (2015)
The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma DevelopmentCell Host & Microbe, 17
K. Thorburn, S. Harigopal, V. Reddy, N. Taylor, H. Saene (2006)
High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitisThorax, 61
C. Hall, R. Douglas, J. Geiman (1976)
Respiratory syncytial virus infections in infants: quantitation and duration of shedding.The Journal of pediatrics, 89 1
Amy Newton, Amber Cardani, T. Braciale (2016)
The host immune response in respiratory virus infection: balancing virus clearance and immunopathologySeminars in Immunopathology, 38
H. Bauchner (2009)
Burden of RSV Infection in Young ChildrenNEJM Journal Watch, 2009
H Faden, L Duffy, R Wasielewski (1997)
Relationship between nasopharyngeal colonization and the development of otitis media in children, 175
R. Invernizzi, C. Lloyd, P. Molyneaux (2020)
Respiratory microbiome and epithelial interactions shape immunity in the lungsImmunology, 160
N. Følsgaard, S. Schjørring, B. Chawes, M. Rasmussen, K. Krogfelt, S. Brix, H. Bisgaard (2013)
Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release.American journal of respiratory and critical care medicine, 187 6
Nicholas Arpaia, Clarissa Campbell, Xiying Fan, Stanislav Dikiy, J. Veeken, P. Deroos, Hui Liu, J. Cross, K. Pfeffer, P. Coffer, A. Rudensky (2013)
Metabolites produced by commensal bacteria promote peripheral regulatory T cell generationNature, 504
V. Avadhanula, C. Rodriguez, J. DeVincenzo, Yan Wang, R. Webby, G. Ulett, E. Adderson (2006)
Respiratory Viruses Augment the Adhesion of Bacterial Pathogens to Respiratory Epithelium in a Viral Species- and Cell Type-Dependent MannerJournal of Virology, 80
S. Ralston, Vanessa Hill, A. Waters (2011)
Occult serious bacterial infection in infants younger than 60 to 90 days with bronchiolitis: a systematic review.Archives of pediatrics & adolescent medicine, 165 10
Chian-Feng Huang, W. Chie, I. Wang (2018)
Efficacy of Lactobacillus Administration in School-Age Children with Asthma: A Randomized, Placebo-Controlled TrialNutrients, 10
L. Petecchia, F. Sabatini, C. Usai, E. Caci, L. Varesio, G. Rossi (2012)
Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathwayLaboratory Investigation, 92
Jeannette Kast, A. McFarlane, Anna Głobińska, M. Sokolowska, P. Wawrzyniak, Marek Sanak, Jürgen Schwarze, C. Akdis, Kerstin Wanke (2017)
Respiratory syncytial virus infection influences tight junction integrityClinical & Experimental Immunology, 190
R. Gosens, P. Hiemstra, I. Adcock, K. Bracke, R. Dickson, P. Hansbro, S. Krauss‐Etschmann, H. Smits, F. Stassen, S. Bartel (2020)
Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung diseaseThe European Respiratory Journal, 56
ORal Bacterial EXtracts for the prevention of wheezing lower respiratory tract illness (ORBEX) trial (ClinTrials.gov ldetifier NCT02148796)
K. Hasegawa, J. Mansbach, N. Ajami, J. Espinola, D. Henke, J. Petrosino, P. Piedra, C. Shaw, A. Sullivan, C. Camargo (2016)
Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitisEuropean Respiratory Journal, 48
Paul Bergeson, J. Shaw (2001)
Are Infants Really Obligatory Nasal Breathers?Clinical Pediatrics, 40
J. Mansbach, Pamela Luna, C. Shaw, K. Hasegawa, J. Petrosino, P. Piedra, A. Sullivan, J. Espinola, C. Stewart, C. Camargo (2019)
Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezingThe Journal of Allergy and Clinical Immunology, 145
C. Stewart, J. Mansbach, M. Wong, N. Ajami, J. Petrosino, C. Camargo, K. Hasegawa (2017)
Associations of Nasopharyngeal Metabolome and Microbiome with Severity among Infants with Bronchiolitis. A Multiomic AnalysisAmerican Journal of Respiratory and Critical Care Medicine, 196
G. Rossi, H. Fanous, A. Colin (2020)
Pediatric Pulmonology
P. Souëf (2018)
Viral infections in wheezing disordersEuropean Respiratory Review, 27
Xiaoyan Zhang, Xiang Zhang, N. Zhang, Xinglan Wang, Lin Sun, Ning Chen, Shunying Zhao, Qiushui He (2019)
Airway microbiome, host immune response and recurrent wheezing in infants with severe respiratory syncytial virus bronchiolitisPediatric Allergy and Immunology, 31
Geovanny Perez, M. Pérez‐Losada, N. Isaza, M. Rose, A. Colberg-Poley, G. Nino (2017)
Nasopharyngeal microbiome in premature infants and stability during rhinovirus infectionJournal of Investigative Medicine, 65
J. Mansbach, K. Hasegawa, P. Piedra, V. Avadhanula, J. Petrosino, A. Sullivan, J. Espinola, C. Camargo (2018)
Haemophilus-Dominant Nasopharyngeal Microbiota Is Associated With Delayed Clearance of Respiratory Syncytial Virus in Infants Hospitalized for BronchiolitisThe Journal of Infectious Diseases, 219
M. Arrieta, Leah Stiemsma, P. Dimitriu, L. Thorson, Shannon Russell, Sophie Yurist-Doutsch, B. Kuzeljevic, Matthew Gold, Heidi Britton, D. Lefebvre, P. Subbarao, P. Mandhane, A. Becker, K. McNagny, M. Sears, T. Kollmann, Child Investigators, W. Mohn, S. Turvey, B. Finlay (2015)
Early infancy microbial and metabolic alterations affect risk of childhood asthmaScience Translational Medicine, 7
Zili Jiang, N. Nagata, Edgar Molina, L. Bakaletz, Hal Hawkins, J. Patel (1999)
Fimbria-Mediated Enhanced Attachment of NontypeableHaemophilus influenzae to Respiratory Syncytial Virus-Infected Respiratory Epithelial CellsInfection and Immunity, 67
G. Rossi, P. Pohunek, W. Feleszko, S. Ballarini, A. Colin (2020)
Viral infections and wheezing–asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?Clinical and Translational Allergy, 10
J. Hament, P. Aerts, A. Fleer, H. Dijk, T. Harmsen, J. Kimpen, T. Wolfs (2005)
Direct Binding of Respiratory Syncytial Virus to Pneumococci: A Phenomenon That Enhances Both Pneumococcal Adherence to Human Epithelial Cells and Pneumococcal Invasiveness in a Murine ModelPediatric Research, 58
A. Díaz-Díaz, Cristina Garcia-Mauriño, A. Jordán-Villegas, Jeffrey Naples, O. Ramilo, A. Mejías (2019)
Viral Bacterial Interactions in Children: Impact on Clinical Outcomes.Pediatric Infectious Disease Journal
H. Nair, D. Nokes, Bradford Gessner, M. Dherani, S. Madhi, R. Singleton, Katherine O'Brien, A. Roca, Peter Wright, N. Bruce, A. Chandran, E. Theodoratou, A. Sutanto, E. Sedyaningsih, M. Ngama, P. Munywoki, C. Kartasasmita, Eric Simões, I. Rudan, Martin Weber, H. Campbell (2010)
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysisLancet, 375
H. Meissner (2016)
Viral Bronchiolitis in Children.The New England journal of medicine, 374 1
Geovanny Perez, Krishna Pancham, Shehlanoor Huseni, Amish Jain, C. Rodríguez‐Martínez, D. Preciado, M. Rose, G. Nino (2015)
Rhinovirus‐induced airway cytokines and respiratory morbidity in severely premature childrenPediatric Allergy and Immunology, 26
Embriette Hyde, J. Petrosino, P. Piedra, C. Camargo, J. Espinola, J. Mansbach (2014)
Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis.The Journal of allergy and clinical immunology, 133 4
C. Lal, C. Travers, Z. Aghai, P. Eipers, T. Jilling, B. Halloran, W. Carlo, Jordan Keeley, G. Rezonzew, Ranjit Kumar, C. Morrow, V. Bhandari, N. Ambalavanan (2016)
The Airway Microbiome at BirthScientific Reports, 6
L. Duttweiler, D. Nadal, B. Frey (2004)
Pulmonary and systemic bacterial co-infections in severe RSV bronchiolitisArchives of Disease in Childhood, 89
D. Nguyen, Rogier Louwen, K. Elberse, G. Amerongen, S. Yüksel, A. Luijendijk, A. Osterhaus, W. Duprex, R. Swart (2015)
Streptococcus pneumoniae Enhances Human Respiratory Syncytial Virus Infection In Vitro and In VivoPLoS ONE, 10
D. Levine, S. Platt, P. Dayan, C. Macias, J. Zorc, W. Krief, J. Schor, D. Bank, N. Fefferman, K. Shaw, N. Kuppermann (2004)
Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections.Pediatrics, 113 6
P. Kanmani, Patricia Clua, M. Vizoso-Pinto, C. Rodríguez, S. Alvarez, V. Melnikov, Hideki Takahashi, H. Kitazawa, J. Villena (2017)
Respiratory Commensal Bacteria Corynebacterium pseudodiphtheriticum Improves Resistance of Infant Mice to Respiratory Syncytial Virus and Streptococcus pneumoniae SuperinfectionFrontiers in Microbiology, 8
M. Suárez-Arrabal, Cesar Mella, S. Lopez, Nicole Brown, M. Hall, S. Hammond, W. Shiels, J. Groner, M. Marcon, O. Ramilo, A. Mejías (2015)
Nasopharyngeal bacterial burden and antibiotics: Influence on inflammatory markers and disease severity in infants with respiratory syncytial virus bronchiolitis.The Journal of infection, 71 4
D. Weinberger, K. Klugman, C. Steiner, L. Simonsen, C. Viboud (2015)
Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization DataPLoS Medicine, 12
GA Rossi, H Fanous, AA Colin (2020)
Viral strategies predisposing to respiratory bacterial superinfections, 55
H. Bisgaard, M. Hermansen, F. Buchvald, L. Loland, L. Halkjaer, K. Bønnelykke, M. Brasholt, Andreas Heltberg, N. Vissing, S. Thorsen, M. Stage, C. Pipper (2007)
Childhood asthma after bacterial colonization of the airway in neonates.The New England journal of medicine, 357 15
J. Brealey, P. Sly, P. Young, K. Chappell (2015)
Viral bacterial co-infection of the respiratory tract during early childhood.FEMS microbiology letters, 362 10
Lena Heung, C. Luberto, M. Poeta (2006)
Role of Sphingolipids in Microbial PathogenesisInfection and Immunity, 74
C. Rosas-Salazar, M. Shilts, A. Tovchigrechko, S. Schobel, J. Chappell, E. Larkin, T. Gebretsadik, R. Halpin, K. Nelson, M. Moore, L. Anderson, S. Peebles, Suman Das, T. Hartert (2018)
Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancyThe Journal of Allergy and Clinical Immunology, 142
B. Resch, W. Gusenleitner, W. Mueller (2007)
Risk of concurrent bacterial infection in preterm infants hospitalized due to respiratory syncytial virus infectionActa Pædiatrica, 96
F. Gulraiz, Carla Rellinghausen, C. Bruggeman, F. Stassen (2015)
Haemophilus influenzae increases the susceptibility and inflammatory response of airway epithelial cells to viral infectionsThe FASEB Journal, 29
A. Kozik, Yvonne Huang (2019)
The microbiome in asthma: Role in pathogenesis, phenotype, and response to treatment.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 122 3
M. Titus, S. Wright (2003)
Prevalence of serious bacterial infections in febrile infants with respiratory syncytial virus infection.Pediatrics, 112 2
Haruka Hishiki, N. Ishiwada, Chie Fukasawa, Katsuaki Abe, T. Hoshino, J. Aizawa, N. Ishikawa, Y. Kohno (2011)
Incidence of bacterial coinfection with respiratory syncytial virus bronchopulmonary infection in pediatric inpatientsJournal of Infection and Chemotherapy, 17
Á. Gentile (2014)
[U.S. hospitalizations for pneumonia after a decade of pneumococcal vaccination].Archivos argentinos de pediatria, 112 3
O. Sakwinska, Viktoria Schmid, B. Berger, A. Bruttin, K. Keitel, Mélissa Lepage, D. Moine, C. Bru, H. Brüssow, A. Gervaix (2014)
Nasopharyngeal Microbiota in Healthy Children and Pneumonia PatientsJournal of Clinical Microbiology, 52
R. Dickson, J. Erb-Downward, F. Martinez, G. Huffnagle (2016)
The Microbiome and the Respiratory Tract.Annual review of physiology, 78
The immunopathology of respiratory syncytial virus (RSV) infection varies considerably, severe disease occurring only in a minority of the affected children. The variability of the clinical presentation is in part explained by viral and environmental factors but, in infants and young children, disease severity is certainly linked to the physiologic immaturity of the innate and adaptive immune system. There is evidence that the maturation of the host immune response is positively influenced by the composition of the nasopharyngeal microbiome that, promoting an efficient reaction, can counteract the predisposition to develop viral respiratory infections and lower the risk of disease severity. However, interaction between the nasopharyngeal microbiota and respiratory viruses can be bidirectional since microbial dysbiosis may also represent a reflection of the disease‐induced alterations of the local milieu. Moreover, viruses like RSV can also increase the virulence of potential pathogens in nasopharynx, a main reservoir of bacteria, and therefore promote their spread to the lower airways causing superinfection. Moreover, if negative changes in microbial community composition in early life may constitute a heightened risk toward severe RSV respiratory infection, on the contrary specific groups of microorganisms seem to be associated with protection. A better understanding into the potential negative and positive role of the different nasopharyngeal bacterial species on RSV infection may improve primary prevention and possibly care of this highly contagious disorder.
Pediatric Allergy and Immunology – Wiley
Published: Aug 1, 2021
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