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Relatives of probands: models for preliminary genetic analysis

Relatives of probands: models for preliminary genetic analysis BY M. A. CAMPBELL* AND R. C. ELSTON Department of Biostatistics and the Genetics Curriculum, University of North Carolina, C h q e l Hill, North Carolina 27514 1 . INTRODUCTION I n the genetic study of a particular trait it is common practice to summarize the data by stating the frequencies with which the trait occurs among the various types of relatives of probands. Thus we find reported in the literature the proportion of sibs, parents, first cousins, etc., of probands who are affected with the trait. One method of analysis is then to consider the question, under a variety of genetic models, ‘What is the probability that a relative of a proband be affected? ’ A comparison of these expected probabilities of being affected with the reported empirical proportions will then give a clue as to which genetic hypothesis is the most appropriate. Li & Sacks (1954) introduced three basic stochastic matrices for the purpose of deriving the joint distribution and correlation between relatives, appropriate for monozygotic twins, children (or parents) and unrelated individuals respectively. These same matrices and others of a similar nature can be used to answer the question posed above. Each of these http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Relatives of probands: models for preliminary genetic analysis

Annals of Human Genetics , Volume 35 (2) – Oct 1, 1971

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References (12)

Publisher
Wiley
Copyright
Copyright © 1971 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1956.tb01395.x
Publisher site
See Article on Publisher Site

Abstract

BY M. A. CAMPBELL* AND R. C. ELSTON Department of Biostatistics and the Genetics Curriculum, University of North Carolina, C h q e l Hill, North Carolina 27514 1 . INTRODUCTION I n the genetic study of a particular trait it is common practice to summarize the data by stating the frequencies with which the trait occurs among the various types of relatives of probands. Thus we find reported in the literature the proportion of sibs, parents, first cousins, etc., of probands who are affected with the trait. One method of analysis is then to consider the question, under a variety of genetic models, ‘What is the probability that a relative of a proband be affected? ’ A comparison of these expected probabilities of being affected with the reported empirical proportions will then give a clue as to which genetic hypothesis is the most appropriate. Li & Sacks (1954) introduced three basic stochastic matrices for the purpose of deriving the joint distribution and correlation between relatives, appropriate for monozygotic twins, children (or parents) and unrelated individuals respectively. These same matrices and others of a similar nature can be used to answer the question posed above. Each of these

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1971

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