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Relative influence of genes and micro‐environment on human chromosome length

Relative influence of genes and micro‐environment on human chromosome length BY F. GIANNELLI, B. HERREROS," AND C. A. B. SMITH Paediatric Research Unit, Guy's Hospital, London, X.E. 1 and Crcclton Laboratory, University College, London, W.C. 1 Recent papers (Atkins & Santesson, 1966; Ockey, Wennstrom & De La Chapelle, 1966; Chandra & Hungerford, 1967 ;German, 1966; Kikuchi & Sandberg, 1964; Lima-de-Faria,Bianchi & Nowell, 1967; Marshall Graves, 1967; Sandberg et al. 1968; De Capoa etal. 1968; Ockey, 1969) have discussed the length differences between homologous chromosomes and the similarity of their DNA synthesis. Further understanding may be obtained from the study of endoreduplicated and tetraploid cells. In these cells the whole chromosome complement is doubled. Thus, for example, there are four number 1 chromosomes, consisting of two homologous pairs of 'sister chromosomes'. Each of the two sister chromosomes are genetically alike. These chromosomes lie close together in endoreduplications (Fig. 1) but much less close in tetraploids. The question therefore arises whether in endoreduplications sister chromosomesdiffer from each other by a lesser extent than non-sister chromosomes, and if so by how much? If sister chromosomes turn out to be very similar, then either the length is controlled mainly by the genes on the chromosome or the close proximity and, therefore, similm http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Relative influence of genes and micro‐environment on human chromosome length

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References (18)

Publisher
Wiley
Copyright
Copyright © 1970 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1970.tb01659.x
Publisher site
See Article on Publisher Site

Abstract

BY F. GIANNELLI, B. HERREROS," AND C. A. B. SMITH Paediatric Research Unit, Guy's Hospital, London, X.E. 1 and Crcclton Laboratory, University College, London, W.C. 1 Recent papers (Atkins & Santesson, 1966; Ockey, Wennstrom & De La Chapelle, 1966; Chandra & Hungerford, 1967 ;German, 1966; Kikuchi & Sandberg, 1964; Lima-de-Faria,Bianchi & Nowell, 1967; Marshall Graves, 1967; Sandberg et al. 1968; De Capoa etal. 1968; Ockey, 1969) have discussed the length differences between homologous chromosomes and the similarity of their DNA synthesis. Further understanding may be obtained from the study of endoreduplicated and tetraploid cells. In these cells the whole chromosome complement is doubled. Thus, for example, there are four number 1 chromosomes, consisting of two homologous pairs of 'sister chromosomes'. Each of the two sister chromosomes are genetically alike. These chromosomes lie close together in endoreduplications (Fig. 1) but much less close in tetraploids. The question therefore arises whether in endoreduplications sister chromosomesdiffer from each other by a lesser extent than non-sister chromosomes, and if so by how much? If sister chromosomes turn out to be very similar, then either the length is controlled mainly by the genes on the chromosome or the close proximity and, therefore, similm

Journal

Annals of Human GeneticsWiley

Published: May 1, 1970

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