Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study... INTRODUCTIONHematopoietic stem cell transplantation (HSCT) is a potentially curative option for many diseases, such as hematologic malignancies and refractory solid tumours among children and adolescents (Miano et al., 2007). Its use in the paediatric population has increased over the last three decades as have its survival rates (Barriga et al., 2012). Despite this, HSCT causes a significant number of clinical complications and side effects, both in the short term (e.g., mucositis, fever, nausea and vomiting) and in the long term (e.g., organ toxicities and fatigue) (Kabak et al., 2019). Indeed, allogeneic HSCT recipients can develop graft‐versus‐host disease that can lead to extensive multi‐organ failure, system toxicities and mortality (Blazar et al., 2012). Due to the previous treatments, the severity of the conditioning regimen, length of isolation and hospitalisation, physical, cognitive and psychosocial functions can all be severely impaired (Chamorro‐Viña et al., 2010; Oeffinger et al., 2009), with a consequent reduction in autonomy and quality of life (QoL) (Hacker et al., 2006).Recent studies showed exercise and rehabilitation as a promising tool to decrease the side effects of HSCT and improve QoL in paediatric population undergoing HSCT (Lago et al., 2020; Martha et al., 2021). A systematic meta‐analysis review (Lago et al., 2020) reported that physical exercise is safe, feasible and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Cancer Care Wiley

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Download PDF
10 pages

Loading next page...
 
/lp/wiley/rehabilitation-in-children-and-adolescents-undergoing-stem-cell-ptteGPEwNL
Publisher
Wiley
Copyright
© 2022 John Wiley & Sons Ltd
ISSN
0961-5423
eISSN
1365-2354
DOI
10.1111/ecc.13711
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONHematopoietic stem cell transplantation (HSCT) is a potentially curative option for many diseases, such as hematologic malignancies and refractory solid tumours among children and adolescents (Miano et al., 2007). Its use in the paediatric population has increased over the last three decades as have its survival rates (Barriga et al., 2012). Despite this, HSCT causes a significant number of clinical complications and side effects, both in the short term (e.g., mucositis, fever, nausea and vomiting) and in the long term (e.g., organ toxicities and fatigue) (Kabak et al., 2019). Indeed, allogeneic HSCT recipients can develop graft‐versus‐host disease that can lead to extensive multi‐organ failure, system toxicities and mortality (Blazar et al., 2012). Due to the previous treatments, the severity of the conditioning regimen, length of isolation and hospitalisation, physical, cognitive and psychosocial functions can all be severely impaired (Chamorro‐Viña et al., 2010; Oeffinger et al., 2009), with a consequent reduction in autonomy and quality of life (QoL) (Hacker et al., 2006).Recent studies showed exercise and rehabilitation as a promising tool to decrease the side effects of HSCT and improve QoL in paediatric population undergoing HSCT (Lago et al., 2020; Martha et al., 2021). A systematic meta‐analysis review (Lago et al., 2020) reported that physical exercise is safe, feasible and

Journal

European Journal of Cancer Care – Wiley

Published: Nov 1, 2022

Keywords: adolescents; children; fatigue; hematopoietic stem cell transplantation; motor performance; physical therapy

References

  • Hematopoietic stem cell transplantation: Clinical use and perspectives
    Barriga, F.; Ramírez, P.; Wietstruck, A.; Rojas, N.
  • Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: Benefits of a moderate exercise intervention
    Baumann, F. T.; Zopf, E. M.; Nykamp, E.; Kraut, L.; Schüle, K.; Elter, T.; Fauser, A. A.; Bloch, W.
  • Specific deficit analyses in motor performance and quality of life of pediatric cancer patients—A cross‐sectional pilot study
    Beulertz, J.; BlochW, P. A.; Baumann, F. T.
  • Ankle dorsiflexion in childhood cancer patients: A review of the literature
    Beulertz, J.; Wurz, A.; Culos‐Reed, N.; Chamorro Viña, C.; Bloch, W.; Baumann, F. T.
  • Manual muscle testing‐force profiles and their reproducibility
    Bittmann, F. N.; Dech, S.; Aehle, M.; Schaefer, L. V.
  • Advances in graft‐versus‐host disease biology and therapy
    Blazar, B. R.; Murphy, W. J.; Abedi, M.
  • Feasibility of an inpatient exercise intervention for children undergoing hematopoietic stem cell transplant
    Bogg, T. F. T.; Broderick, C.; Shaw, P.; Cohn, R.; Naumann, F. L.
  • Psychophysical bases of perceived exertion
    Borg, G. A.
  • How we design feasibility studies
    Bowen, D. J.; Kreuter, M.; Spring, B.; Cofta‐Woerpel, L.; Linnan, L.; Weiner, D.; Bakken, S.; Kaplan, C. P.; Squiers, L.; Fabrizio, C.; Fernandez, M.
  • Biomechanics of the ankle
    Brockett, C. L.; Chapman, G. J.
  • EXERCISE in pediatric autologous stem cell transplant patients: A randomized controlled trial protocol
    Chamorro‐Viña, C.; Guilcher, G. M. T.; Khan, F. M.; Mazil, K.; Schulte, F.; Wurz, A.; Williamson, T.; Reimer, R. A.; Culos‐Reed, S. N.
  • Exercise during hematopoietic stem cell transplant hospitalization in children
    Chamorro‐Viña, C.; Ruiz, J. R.; Santana‐Sosa, E.; González Vicent, M.; Madero, L.; Pérez, M.; Fleck, S. J.; Pérez, A.; Ramírez, M.; Lucía, A.
  • Improving occupational performance in pediatric hematopoietic cell transplant recipients
    Colman, J.; Casto, S. C.; Wisner, E.; Stanek, J. R.; Auletta, J. J.
  • A pilot study to evaluate the feasibility of individualized yoga for inpatient children receiving intensive chemotherapy
    Diorio, C.; Schechter, T.; Lee, M.; O'Sullivan, C.; Hesser, T.; Tomlinson, D.; Piscione, J.; Armstrong, C.; Tomlinson, G.; Sung, L.
  • Move to improve: The feasibility of using an early mobility protocol to increase ambulation in the intensive and intermediate care settings
    Drolet, A.; DeJuilio, P.; Harkless, S.; Henricks, S.; Kamin, E.; Leddy, E. A.; Lloyd, J. M.; Waters, C.; Williams, S.
  • Clinical measurement of range of motion: Review of goniometry emphasizing reliability and validity
    Gajdosik, R.; Bohannon, R.
  • Data analysis using regression and multilevel/hierarchical models
    Gelman, A.; Hill, J.
  • Heavy to carry: A survey of parents' and healthcare professionals' perceptions of cancer‐related fatigue in children and young people
    Gibson, F.; Garnett, M.; Richardson, A.; Edwards, J.; Sepion, B.
  • Physician referral frequency for physical therapy in children with acute lymphoblastic leukemia
    Gohar, S. F.; Marchese, V.; Comito, M.
  • Transplant energize me patient outcome (TEMPO): A quality improvement project that maintains functional mobility in pediatric patients admitted for allogeneic hematopoietic cell transplantation
    Gonzales, A.; Gates, E.; Bhunia, N.; Mehyar, L.; Hashem, H.; Stanek, J. R.; Krebs, B.; Auletta, J. J.
  • Fatigue and physical activity in patients undergoing hematopoietic stem cell transplant
    Hacker, E. D.; Ferrans, C.; Verlen, E.; Ravandi, F.; Besien, K.; Gelms, J.; Dieterle, N.
  • Mobilization patterns of children on a hematology/oncology inpatient ward
    Johnston, K.; Deliva, R.; Evans, C.
  • Effects of multimodal exercise on clinical status and patient‐reported outcomes in children undergoing hematopoietic stem cell transplantation
    Kabak, V. Y.; Cetinkaya, D. U.; Kuskonmaz, B.; Cetin, N.; Duger, T.
  • On the use of the upper confidence limit for the variance from a pilot sample for sample size determination
    Kieser, M.; Wassmer, G.
  • Effects of physical exercise for children and adolescents undergoing hematopoietic stem cell transplantation: A systematic review and meta‐analysis
    Lago, A. S.; Zaffarani, C.; Mendonça, J. F. B.; Moran, C. A.; Costa, D.; Gomes, E. L. F. D.
  • Effect of physical exercise on the functional capacity of children and adolescents submitted to transplantation of hematopoietic stem cells—A systematic review with meta‐analysis
    Martha, B. A.; Vacchi, C. O.; Fattori, R. A.; Macagnan, F. E.
  • Criterion‐related validity of sit‐and‐reach tests for estimating hamstring and lumbar extensibility: A meta‐analysis
    Mayorga‐Vega, D.; Merino‐Marban, R.; Viciana, J.
  • Haematopoietic stem cell transplantation trends in children over the last three decades: A survey by the paediatric diseases working party of the European group for blood and marrow transplantation
    Miano, M.; Labopin, M.; Hartmann, O.; Angelucci, E.; Cornish, J.; Gluckman, E.; Locatelli, F.; Fischer, A.; Egeler, R. M.; Or, R.; Ortega, J.; Veys, P.; Bordigoni, P.; Iori, A. P.; Niethammer, D.; Rocha, V.; Dini, G.
  • Impaired physiological function and health‐related QOL in patients before hematopoietic stem‐cell transplantation
    Morishita, S.; Kaida, K.; Ikegame, K.; Yoshihara, S.; Taniguchi, K.; Okada, M.; Kodama, N.; Ogawa, H.; Domen, K.
  • Timed "up & go" test in children and adolescents
    Nicolini‐Panisson, R. D.; Donadio, M. V.
  • ND physical activity prescription: Our best medicine
    Oberg, E.
  • Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta‐analysis of randomized trials
    Oberoi, S.; Robinson, P. D.; Cataudella, D.; Culos‐Reed, S. N.; Davis, H.; Duong, N.; Gibson, F.; Götte, M.; Hinds, P.; Nijhof, S. L.; Tomlinson, D.; Torre, P.; Cabral, S.; Dupuis, L. L.; Sung, L.
  • Survivorship: Childhood cancer survivors
    Oeffinger, K. C.; Hudson, M. M.; Landier, W.
  • Motivation and physiologic responses of playing a physically interactive video game relative to a sedentary alternative in children
    Penko, A. L.; Barkley, J. E.
  • Effects of exercise in patients treated with stem cell transplantation for a hematologic malignancy: A systematic review and meta‐analysis
    Persoon, S.; Kersten, M. J.; Weiden, K.; Buffart, L. M.; Nollet, F.; Brug, J.; Chinapaw, M. J.
  • Role of video games in improving health‐related outcomes
    Primack, B. A.; Carroll, M. V.; McNamara, M.; Klem, M. L.; King, B.; Rich, M. O.; Chan, C. W.; Nayak, S.
  • R: A language and environment for statistical computing
  • Rehabilitative intervention during and after pediatric hematopoietic stem cell transplantation: An analysis of the existing literature
    Rossi, F.; Coppo, M.; Zucchetti, G.; Bazzano, D.; Ricci, F.; Vassallo, E.; Nesi, F.; Fagioli, F.
  • The Italian consensus conference on the role of rehabilitation for children and adolescents with leukemia, central nervous system, and bone tumors, part 1: Review of the conference and presentation of consensus statements on rehabilitative evaluation of motor aspects
    Rossi, F.; Ricci, F.; Botti, S.; Bertin, D.; Breggiè, S.; Casalaz, R.; Cervo, M.; Ciullini, P.; Coppo, M.; Cornelli, A.; Esposito, M.; Ferrarese, M.; Ghetti, M.; Longo, L.; Morri, M.; Naretto, G.; Orsini, N.; Fagioli, F.
  • The gross motor function measure: A means to evaluate the effects of physical therapy
    Russell, D. J.; Rosenbaum, P. L.; Cadman, D. T.; Gowland, C.; Hardy, S.; Jarvis, S.
  • Psychophysical effects of an exercisetherapy during pediatric stem cell transplantation: A randomized controlled trial
    Senn‐Malashonak, A.; Wallek, S.; Schmidt, K.; Rosenhagen, A.; Vogt, L.; Bader, P.; Banzer, W.
  • Impact of exercise on lower activity levels in children with acute lymphoblastic leukemia: A randomized controlled trial from Turkey
    Tanir, M. K.; Kuguoglu, S.
  • Nijhuis‐van der Sanden MW. Physical exercise for patients undergoing hematopoietic stem cell transplantation: Systematic review and meta‐analyses of randomized controlled trials
    Haren, I. E.; Timmerman, H.; Potting, C. M.; Blijlevens, N. M.; Staal, J. B.
  • The PedsQL in pediatric cancer: Reliability and validity of the pediatric quality of life inventory generic Core scales, multidimensional fatigue scale, and Cancer module
    Varni, J. W.; Burwinkle, T. M.; Katz, E. R.; Meeske, K.; Dickinson, P.
  • The PedsQL multidimensional fatigue scale in pediatric rheumatology: Reliability and validity
    Varni, J. W.; Burwinkle, T. M.; Szer, I. S.
  • Impact of the initial fitness level on the effects of astructured exercise therapy during pediatric stem celltransplantation
    Wallek, S.; Senn‐Malashonak, A.; Vogt, L.; Schmidt, K.; Bader, P.; Banzer, W.
  • Impaired respiratory and skeletal muscle strength in patients prior to hematopoietic stem‐cell transplantation
    White, A. C.; Terrin, N.; Miller, K. B.; Ryan, H. F.
  • Effects of a partly self‐administered exercise program before, during, and after allogeneic stem cell transplantation
    Wiskemann, J.; Dreger, P.; Schwerdtfeger, R.; Bondong, A.; Huber, G.; Kleindienst, N.; Ulrich, C. M.; Bohus, M.
  • Physical exercise as adjuvant therapy for patients undergoing hematopoietic stem cell transplantation
    Wiskemann, J.; Huber, G.
  • Adaptation and psychometric properties of the gross motor function measure for children receiving treatment for acute lymphoblastic leukemia
    Wright, M. J.
  • Investigation of the effects of an exercise program on physical functions and activities of daily life in pediatric hematopoietic stem cell transplantation
    Yildiz Kabak, V.; Duger, T.; Uckan, C. D.
  • Exercise program for children and adolescents with leukemia and lymphoma during treatment: A comprehensive review
    Zucchetti, G.; Rossi, F.; Chamorro Vina, C.; Bertorello, N.; Fagioli, F.