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T. Al-Dabbagh (2008)
Risk factors associated with esophageal cancer in North of Iran.Saudi medical journal, 29 1
A. Moradi (2008)
Risk Factors associated with esophageal cancer in North of Iran. Authors' replySaudi Medical Journal, 29
Che-Hong Chen, G. Budas, E. Churchill, M. Disatnik, T. Hurley, D. Mochly‐Rosen (2008)
Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the HeartScience, 321
A. Yokoyama, H. Kato, T. Yokoyama, H. Igaki, T. Tsujinaka, M. Muto, T. Omori, Y. Kumagai, Masako Yokoyama, Hiroshi Watanabe (2006)
Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.Alcoholism, clinical and experimental research, 30 3
A. Yokoyama, T. Muramatsu, Tai Omori, T. Yokoyama, S. Matsushita, Susumu Higuchi, K. Maruyama, H. Ishii (2001)
Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics.Carcinogenesis, 22 3
T. Reich, H. Edenberg, A. Goate, Jeff Williams, J. Rice, P. Eerdewegh, T. Foroud, V. Hesselbrock, M. Schuckit, K. Bucholz, B. Porjesz, Ting-kai Li, P. Conneally, J. Nurnberger, J. Tischfield, R. Crowe, C. Cloninger, William Wu, S. Shears, Kristie Carr, Candice Crose, Chris Willig, H. Begleiter (1998)
Genome-wide search for genes affecting the risk for alcohol dependence.American journal of medical genetics, 81 3
J. Long, W. Knowler, R. Hanson, R. Robin, M. Urbanek, Elisa Moore, Peter Bennett, D. Goldman (1998)
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population.American journal of medical genetics, 81 3
(2007)
Study on the Population Genetic Characteristics of Esophageal Cancer
Norma Greenfield, R. Pietruszko (1977)
Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.Biochimica et biophysica acta, 483 1
Hiroki Oota, A. Pakstis, B. Bonné-Tamir, D. Goldman, E. Grigorenko, S. Kajuna, N. Karoma, Selemani Kungulilo, R. Lu, K. Odunsi, F. Okonofua, O. Zhukova, J. Kidd, K. Kidd (2004)
The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombinationAnnals of Human Genetics, 68
Shu-juan Yang, Hua-yu Wang, Xiao-qing Li, Hui-zhang Du, Can-jie Zheng, Huai-gong Chen, X. Mu, Chun-Xia Yang (2007)
Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China.World journal of gastroenterology, 13 43
(2005)
Life-style and Gene Polymorphisms on Esophageal Cancer Risk
G. Stamatoyannopoulos, S. Chen, M. Fukui (1975)
Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.American journal of human genetics, 27 6
M. Hashibe, J. Mckay, M. Curado, J. Oliveira, S. Koifman, R. Koifman, D. Zaridze, O. Shangina, V. Wünsch-Filho, J. Eluf-Neto, J. Levi, E. Matos, P. Lagiou, A. Lagiou, S. Benhamou, C. Bouchardy, N. szeszenia-Dabrowska, A. Menezes, M. Dall'Agnol, F. Merletti, L. Richiardi, L. Fernandez, J. Lence, R. Talamini, L. Barzan, D. Mates, I. Mateș, K. Kjaerheim, G. Macfarlane, T. Macfarlane, L. Simonato, C. Canova, I. Holcatova, A. Agudo, X. Castellsagué, R. Lowry, V. Janout, H. Kollárová, D. Conway, P. McKinney, A. Znaor, E. Fabiánová, V. Bencko, J. Lissowska, Amélie Chabrier, R. Hung, V. Gaborieau, P. Boffetta, P. Brennan (2008)
Multiple ADH genes are associated with upper aerodigestive cancersNature Genetics, 40
Wu Jian (2001)
Polymorphisms of Aldehyde Dehydrogenase-2 Genotypes and the Risk of Esophageal CancerBulletin of Chinese Cancer
J. D. Hempel, R. Pietruszko (1978)
Structural distinctness of the isozymes of human liver aldehyde dehydrogenase, 37
Yunhua Fan, Jian-Min Yuan, Renwei Wang, Yu-Tang Gao, Mimi Yu (2008)
Alcohol, Tobacco, and Diet in Relation to Esophageal Cancer: The Shanghai Cohort StudyNutrition and Cancer, 60
(2007)
Structural and functional consequences of coenzyme binding to the inactive Asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487
Dong-ping Li, C. Dandara, G. Walther, M. Parker (2008)
Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer, 46
N. Druesne-Pecollo, B. Téhard, Y. Mallet, M. Gerber, T. Norat, S. Hercberg, P. Latino-Martel (2009)
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.The Lancet. Oncology, 10 2
Chiao Chen, R. Lu, Yi Chen, Mingfu Wang, Yue-Cune Chang, Ting-kai Li, S. Yin (1999)
Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.American journal of human genetics, 65 3
Ku-sheng Wu, Xianqi Huo, Guang Zhu (2007)
Soil and vegetation characteristics of high- and low-risk areas of esophageal cancer in China.Asian Pacific journal of cancer prevention : APJCP, 8 4
Yu-tong He, J. Hou, Zhi-feng Chen, G. Song, Cui-yun Qiao, F. Meng, H. Ji, Chao Chen (2006)
[Study on the esophageal cancer incidence and mortality rate from 1974-2002 in Cixian, China].Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 27 2
E. Algar, R. Holmes (1989)
Kinetic properties of murine liver aldehyde dehydrogenases.Progress in clinical and biological research, 290
(1970)
Cancer Incidence in Five Continents
(2007)
Progress on Aldehyde Dehydrogenase 2 (ALDH2) Gene
D. Goldman, M. Enoch (1990)
Genetic epidemiology of ethanol metabolic enzymes: a role for selection.World review of nutrition and dietetics, 63
A. Yoshida, I. Huang, M. Ikawa (1984)
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.Proceedings of the National Academy of Sciences of the United States of America, 81 1
P. Wolff (1972)
Ethnic Differences in Alcohol SensitivityScience, 175
E. M. Algar, R. S. Holmes (1989)
Enzymology and molecular biology of carbonyl metabolism 2: aldehyde dehydrogenase, alcohol dehydrogenase, and aldo‐keto reductase (eds. H. Weiner & T. G. Flynn)
(2006)
Allelic Variability and Tests for Natural Selection at the Human ALDH2 Locus
H. G. Chen (2005)
Master dissertation
H. Larson, H. Weiner, T. Hurley (2005)
Disruption of the Coenzyme Binding Site and Dimer Interface Revealed in the Crystal Structure of Mitochondrial Aldehyde Dehydrogenase “Asian” Variant*Journal of Biological Chemistry, 280
A. Yokoyama, T. Omori (2005)
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.Alcohol, 35 3
B. Wen, Hui Li, D. Lu, Xiufeng Song, Feng Zhang, Yungang He, Feng Li, Yang Gao, Xianyun Mao, Liang Zhang, J. Qian, Jingze Tan, Jianzhong Jin, Wei Huang, R. Deka, B. Su, R. Chakraborty, Li Jin (2004)
Genetic evidence supports demic diffusion of Han cultureNature, 431
Chaohui Yu, Youming Li, Weixing Chen, Min Yue (2002)
Genotype of ethanol metabolizing enzyme genes by oligonucleotide microarray in alcoholic liver disease in Chinese people.Chinese medical journal, 115 7
Pardis Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, Xiaohui Xie, E. Byrne, S. Mccarroll, R. Gaudet, S. Schaffner, E. Lander (2007)
Genome-wide detection and characterization of positive selection in human populationsNature, 449
M. Hammer, T. Karafet, Hwayong Park, K. Omoto, S. Harihara, M. Stoneking, S. Horai (2006)
Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomesJournal of Human Genetics, 51
Xingguang Luo, H. Kranzler, Lingjun Zuo, Shuang Wang, N. Schork, J. Gelernter (2006)
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.American journal of human genetics, 78 6
M. Ikawa, C. Impraim, G. Wang, A. Yoshida (1983)
Isolation and characterization of aldehyde dehydrogenase isozymes from usual and atypical human livers.The Journal of biological chemistry, 258 10
(2005)
A Match Case-control Study on Esophageal Cancer Susceptibility with Lifestyle Habits and Genetic Polymorphisms of ALDH2 and ADH2
Yifeng Li, Dandan Zhang, W. Jin, C. Shao, P. Yan, Congjian Xu, Haihui Sheng, Yan Liu, Jin-de Yu, Yuying Xie, Yingnan Zhao, D. Lu, D. Nebert, D. Harrison, Wei Huang, Li Jin (2006)
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.The Journal of clinical investigation, 116 2
W. Li, X. Wang, C. Zhang (1998)
[Esophageal carcinoma in part of population of Yangquan City].Zhonghua yi xue za zhi, 78 3
Patrice Couzigou, Christiane Coutelle, B. Fleury, A. Iron (1994)
Alcohol and aldehyde dehydrogenase genotypes, alcoholism and alcohol related disease.Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 2
(1994)
Study on Genetic Epidemiology of Esophageal Cancer in Shaanxi Region
Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in human alcohol metabolism. The oriental ALDH2*504Lys variant functions as a dominant negative, greatly reducing activity in heterozygotes and abolishing activity in homozygotes. This allele is associated with serious disorders such as alcohol liver disease, late onset Alzheimer disease, colorectal cancer, and esophageal cancer, and is best known for protection against alcoholism. Many hundreds of papers in various languages have been published on this variant, providing allele frequency data for many different populations. To develop a highly refined global geographic distribution of ALDH2*504Lys, we have collected new data on 4,091 individuals from 86 population samples and assembled published data on a total of 80,691 individuals from 366 population samples. The allele is essentially absent in all parts of the world except East Asia. The ALDH2*504Lys allele has its highest frequency in Southeast China, and occurs in most areas of China, Japan, Korea, Mongolia, and Indochina with frequencies gradually declining radially from Southeast China. As the indigenous populations in South China have much lower frequencies than the southern Han migrants from Central China, we conclude that ALDH2*504Lys was carried by Han Chinese as they spread throughout East Asia. Esophageal cancer, with its highest incidence in East Asia, may be associated with ALDH2*504Lys because of a toxic effect of increased acetaldehyde in the tissue where ingested ethanol has its highest concentration. While the distributions of esophageal cancer and ALDH2*504Lys do not precisely correlate, that does not disprove the hypothesis. In general the study of fine scale geographic distributions of ALDH2*504Lys and diseases may help in understanding the multiple relationships among genes, diseases, environments, and cultures.
Annals of Human Genetics – Wiley
Published: Jan 1, 2009
Keywords: ; ; ; ;
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