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Xenotransplantation 2014: 21: 367–375 © 2014 John Wiley & Sons A/S doi: 10.1111/xen.12104 Published by John Wiley & Sons Ltd. XENOTRANSPLANTATION Original Article Recombinant human antithrombin prevents xenogenic activation of hemostasis in a model of pig-to-human kidney transplantation 1 2 Ramackers W, Friedrich L, Klose J, Vondran F, Bergmann S, Wolf Ramackers, Lars Friedrich, 1 1 Schuttl € er W, Johanning K, Werwitzke S, Trummer A, Broc € ker V, Johannes Klose, Florian Vondran, Klempnauer J, Winkler M, Tiede A. Recombinant human Sabine Bergmann, Wolfgang 1 2 antithrombin prevents xenogenic activation of hemostasis in a model of Schuttler, Kai Johanning, Sonja pig-to-human kidney transplantation. Xenotransplantation 2014; 21: 3 3 Werwitzke, Arne Trummer, Verena 367–375. © 2014 John Wiley & Sons A/S. Published by John Wiley & 4 1 € € Brocker, Jurgen Klempnauer, Sons Ltd. 1 3 Michael Winkler and Andreas Tiede Department of General, Visceral and Abstract: Background: Xenogenic activation of hemostasis (XAH) rep- Transplantation Surgery, Hannover Medical School, resents a major hurdle for the transplantation of discordant animal Department of Anesthesiology and Intensive Care, organs into humans as it results in thrombotic microangiopathy (TMA). Hannover Medical School, Department of We have previously shown that recombinant human-activated protein
Xenotransplantation – Wiley
Published: Jan 1, 2014
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