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Recently decreased association of air pollution with cognitive impairment in a population‐based aging cohort and in a mouse model

Recently decreased association of air pollution with cognitive impairment in a population‐based... Particulate matter air pollution is an environmental risk factor for poor cognitive function in the elderly,1–3 together with accelerated cognitive loss,4,5,6 increased risk of dementia,5,7,8 loss of brain grey and white matter,9,10 and small vessel disease.11 Rodent models document the neurotoxicity of air pollution components for cognitive impairments,12,13 oxidative damage and increased brain amyloid,5,14,15 and impaired adult neurogenesis.12,16 Our labs have independently reported indications of recent decreases in the neurotoxicity of air pollution components in human populations17 and rodent models.18In the US‐wide Health and Retirement Study (HRS), Ailshire showed a strong association of cognitive deficits with air pollution for cohorts with lower education in 2004: a 12% higher risk of incident cognitive impairment per 5 μg/m3 increase in PM2.5 among adults ages 65 and older with ≤8 years of education.17 However, by 2014 there was no such association for the corresponding HRS cohort.Among possibilities for the lack of association in 2014, a likely factor is the reduction in PM2.5 from 2004 to 2014. The mean annual ambient PM2.5 in neighborhoods of HRS respondents was 9.2 μg/m3 (SD = 1.7) in 2014, 25% below the 2004 level of 12.4 μg/m3 (SD = 2.8).17 Importantly, in 2014 very few HRS respondents lived in places with an annual average PM2.5 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alzheimer's & Dementia Wiley

Recently decreased association of air pollution with cognitive impairment in a population‐based aging cohort and in a mouse model

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References (28)

Publisher
Wiley
Copyright
© 2022 the Alzheimer's Association.
ISSN
1552-5260
eISSN
1552-5279
DOI
10.1002/alz.12471
Publisher site
See Article on Publisher Site

Abstract

Particulate matter air pollution is an environmental risk factor for poor cognitive function in the elderly,1–3 together with accelerated cognitive loss,4,5,6 increased risk of dementia,5,7,8 loss of brain grey and white matter,9,10 and small vessel disease.11 Rodent models document the neurotoxicity of air pollution components for cognitive impairments,12,13 oxidative damage and increased brain amyloid,5,14,15 and impaired adult neurogenesis.12,16 Our labs have independently reported indications of recent decreases in the neurotoxicity of air pollution components in human populations17 and rodent models.18In the US‐wide Health and Retirement Study (HRS), Ailshire showed a strong association of cognitive deficits with air pollution for cohorts with lower education in 2004: a 12% higher risk of incident cognitive impairment per 5 μg/m3 increase in PM2.5 among adults ages 65 and older with ≤8 years of education.17 However, by 2014 there was no such association for the corresponding HRS cohort.Among possibilities for the lack of association in 2014, a likely factor is the reduction in PM2.5 from 2004 to 2014. The mean annual ambient PM2.5 in neighborhoods of HRS respondents was 9.2 μg/m3 (SD = 1.7) in 2014, 25% below the 2004 level of 12.4 μg/m3 (SD = 2.8).17 Importantly, in 2014 very few HRS respondents lived in places with an annual average PM2.5

Journal

Alzheimer's & Dementia – Wiley

Published: May 1, 2022

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