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Randomization tests of disease‐marker associations

Randomization tests of disease‐marker associations A powerful test for population association of a disease with alleles at a bi‐allelic marker locus is the transmission/disequilibrium test (TDT). A generalization of the test to multi‐allelic marker locus is proposed which utilizes the maximal association of individual alleles with the disease, given by the maximum TDT statistic, TDT(max). To overcome the multiple testing problem encountered when using the maximal association to test the null hypothesis of no disease‐marker association, a randomization procedure is developed. An investigation of the power of the test suggests that the randomization procedure performs almost as well as a recently proposed likelihood based test of linkage disequilibrium. The advantage of the new test is that it can be applied sequentially, based on a one‐sided version of the TDT statistic, for investigating patterns of association of several individual alleles with the disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Randomization tests of disease‐marker associations

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References (12)

Publisher
Wiley
Copyright
Copyright © 1997 Wiley Subscription Services
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1046/j.1469-1809.1997.6110047.x
pmid
9066927
Publisher site
See Article on Publisher Site

Abstract

A powerful test for population association of a disease with alleles at a bi‐allelic marker locus is the transmission/disequilibrium test (TDT). A generalization of the test to multi‐allelic marker locus is proposed which utilizes the maximal association of individual alleles with the disease, given by the maximum TDT statistic, TDT(max). To overcome the multiple testing problem encountered when using the maximal association to test the null hypothesis of no disease‐marker association, a randomization procedure is developed. An investigation of the power of the test suggests that the randomization procedure performs almost as well as a recently proposed likelihood based test of linkage disequilibrium. The advantage of the new test is that it can be applied sequentially, based on a one‐sided version of the TDT statistic, for investigating patterns of association of several individual alleles with the disease.

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1997

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