Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Russell, A. Salustri (2006)
Extracellular matrix of the cumulus-oocyte complex.Seminars in reproductive medicine, 24 4
A. Rossum, F. Fazzini, P. Limburg, A. Manfredi, P. Rovere-Querini, A. Mantovani, C. Kallenberg (2004)
The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages.Arthritis and rheumatism, 50 8
(1997)
Handbook of human genetics
G. Montgomery, Z. Zhao, Anna Marsh, Renee Mayne, S. Treloar, M. James, N. Martin, D. Boomsma, D. Duffy (2004)
A deletion mutation in GDF9 in sisters with spontaneous DZ twins.Twin research : the official journal of the International Society for Twin Studies, 7 6
R. Sear, D. Shanley, I. McGregor, R. Mace (2001)
The fitness of twin mothers: evidence from rural GambiaJournal of Evolutionary Biology, 14
K. Spanel‐borowski (2011)
Ovulation as danger signaling event of innate immunityMolecular and Cellular Endocrinology, 333
A. Mantovani, C. Garlanda, A. Doni, B. Bottazzi (2007)
Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3Journal of Clinical Immunology, 28
S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M. Ferreira, David Bender, J. Maller, P. Sklar, P. Bakker, M. Daly, P. Sham (2007)
PLINK: a tool set for whole-genome association and population-based linkage analyses.American journal of human genetics, 81 3
Chantal Hoekstra, Z. Zhao, C. Lambalk, G. Willemsen, N. Martin, D. Boomsma, G. Montgomery (2008)
Dizygotic twinning.Human reproduction update, 14 1
P. Smith (1871)
The Descent of Man, and Selection in Relation to SexGlasgow Medical Journal, 3
British and Foreign Medico-Chirurg. Review
(2004)
The prototypic tissue pentraxin PTX3, in contrast to the short 462
R. Newman, B. Luke (2000)
Multifetal Pregnancy: A Handbook for Care of the Pregnant Patient
F. Moalli, S. Jaillon, A. Inforzato, M. Sironi, B. Bottazzi, A. Mantovani, C. Garlanda (2011)
Pathogen Recognition by the Long Pentraxin PTX3Journal of Biomedicine and Biotechnology, 2011
Kejun Liu, S. Muse (2005)
PowerMarker: an integrated analysis environment for genetic marker analysisBioinformatics, 21 9
A. Salustri, C. Garlanda, E. Hirsch, M. Acetis, A. Maccagno, Bárbara, Bottazzi, A. Doni, A. Bastone, G. Mantovani, P. Peccoz, G. Salvatori, D. Mahoney, A. Day, G. Siracusa, L. Romani, A. Mantovani (2004)
Summary PTX 3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
B. Bottazzi, C. Garlanda, A. Cotena, F. Moalli, S. Jaillon, Livija Deban, A. Mantovani (2009)
The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunityImmunological Reviews, 227
P. Rovere, G. Peri, F. Fazzini, B. Bottazzi, A. Doni, A. Bondanza, V. Zimmermann, C. Garlanda, Umberto Fascio, M. Sabbadini, C. Rugarli, A. Mantovani, A. Manfredi (2000)
The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells.Blood, 96 13
S. Jaffar, A. Jepson, Amanda Leach, A. Greenwood, H. Whittle, B. Greenwood (1998)
Causes of mortality in twins in a rural region of The Gambia, West Africa.Annals of tropical paediatrics, 18 3
A. Salustri, C. Garlanda, E. Hirsch, M. Acetis, A. Maccagno, B. Bottazzi, A. Doni, A. Bastone, G. Mantovani, P. Peccoz, G. Salvatori, D. Mahoney, A. Day, G. Siracusa, L. Romani, A. Mantovani (2004)
PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization, 131
J. Smits, Christiaan Monden (2011)
Twinning across the Developing WorldPLoS ONE, 6
B. Devlin, N. Risch (1995)
A comparison of linkage disequilibrium measures for fine-scale mapping.Genomics, 29 2
L. May, M. Kuningas, D. Bodegom, H. Meij, M. Frolich, P. Slagboom, A. Mantovani, Rudi Westendorp (2010)
Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women1, 82
J. Barrett, B. Fry, J. Maller, M. Daly (2005)
Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 21 2
D. Hancock, E. Martin, Yi-Ju Li, W. Scott (2007)
Methods for interaction analyses using family‐based case‐control data: conditional logistic regression versus generalized estimating equationsGenetic Epidemiology, 31
S. Varani, J. Elvin, Changning Yan, J. Demayo, F. DeMayo, H. Horton, M. Byrne, M. Matzuk (2002)
Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility.Molecular endocrinology, 16 6
C. Garlanda, B. Bottazzi, A. Bastone, A. Mantovani (2005)
Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.Annual review of immunology, 23
R. Olesen, C. Wejse, C. Wejse, D. Velez, C. Bisseye, M. Sodemann, P. Aaby, P. Rabna, A. Worwui, H. Chapman, M. Diatta, R. Adegbola, P. Hill, L. Østergaard, Scott Williams, G. Sirugo (2007)
DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West AfricansGenes and Immunity, 8
Nylander Pp (1978)
Causes of high twinning frequencies in Nigeria.Progress in Clinical and Biological Research
I. Adzhubei, S. Schmidt, L. Peshkin, V. Ramensky, A. Gerasimova, P. Bork, A. Kondrashov, S. Sunyaev (2010)
A method and server for predicting damaging missense mutationsNature methods, 7
(1992)
Twins in sub-Saharan Africa: frequency, social status and mortality
J. Palmer, Z. Zhao, Chantal Hoekstra, N. Hayward, P. Webb, D. Whiteman, N. Martin, D. Boomsma, D. Duffy, G. Montgomery (2006)
Novel variants in growth differentiation factor 9 in mothers of dizygotic twins.The Journal of clinical endocrinology and metabolism, 91 11
R. Sear, R. Mace, I. McGregor (2000)
Maternal grandmothers improve nutritional status and survival of children in rural GambiaProceedings of the Royal Society of London. Series B: Biological Sciences, 267
P. Nylander (1971)
Ethnic differneces in twinning rates in NigeriaJournal of Biosocial Science, 3
P. Nylander (1969)
The frequency of twinning in a rural community in Western NigeriaAnnals of Human Genetics, 33
T. Thye, F. Vannberg, S. Wong, E. Owusu-Dabo, I. Osei, J. Gyapong, G. Sirugo, F. Sisay-Joof, A. Enimil, M. Chinbuah, S. Floyd, D. Warndorff, L. Sichali, S. Malema, A. Crampin, B. Ngwira, Y. Teo, K. Small, K. Rockett, D. Kwiatkowski, P. Fine, P. Hill, M. Newport, C. Lienhardt, R. Adegbola, T. Corrah, A. Ziegler, A. Morris, C. Meyer, R. Horstmann, A. Hill (2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2Nature genetics, 42
Paolo Parisi, Paolo Parisi, M. Gatti, G. Prinzi, G. Caperna (1983)
Familial incidence of twinningNature, 304
Samuli Helle, V. Lummaa, J. Jokela (2004)
SELECTION FOR INCREASED BROOD SIZE IN HISTORICAL HUMAN POPULATIONS, 58
G. Pison (1992)
Twins in sub‐Saharan Africa: frequency, social status and mortality. In: Mortality and society in sub‐Saharan Africa
V. Lummaa, E. Haukioja, R. Lemmetyinen, M. Pikkola (1998)
Natural selection on human twinningNature, 394
M. Chiarini, C. Sabelli, P. Melotti, C. Garlanda, G. Savoldi, C. Mazza, R. Padoan, A. Plebani, A. Mantovani, L. Notarangelo, B. Assael, R. Badolato (2010)
PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patientsGenes and Immunity, 11
S. Browning, J. Briley, L. Briley, Gyan Chandra, Jonathan Charnecki, M. Ehm, Kelley Johansson, Brendan Jones, A. Karter, D. Yarnall, M. Wagner (2005)
Case‐control single‐marker and haplotypic association analysis of pedigree dataGenetic Epidemiology, 28
L. Høj, David Silva, K. Hedegaard, A. Sandström, P. Aaby (2002)
Factors associated with maternal mortality in rural Guinea‐Bissau. A longitudinal population‐based studyBJOG: An International Journal of Obstetrics & Gynaecology, 109
T. Jenkins (1991)
Genetic Variation and Disorders in Peoples of African OriginJournal of Medical Genetics, 28
H. Schmidt, F. Rösing, D. Schmidt (1984)
Causes of an extremely high local twinning rate.Annals of human biology, 10 4
J. Pate, P. Keyes (2001)
Immune cells in the corpus luteum: friends or foes?Reproduction, 122 5
Dizygotic (DZ) twinning has a genetic component and is common among sub‐Saharan Africans; in The Gambia its frequency is up to 3% of live births. Variation in PTX3, encoding Pentraxin 3, a soluble pattern recognition receptor that plays an important role both in innate immunity and in female fertility, has been associated with resistance to Mycobacterium tuberculosis pulmonary disease and to Pseudomonas aeruginosa infection in cystic fibrosis patients. We tested whether PTX3 variants in Gambian women associate with DZ twinning, by genotyping five PTX3 single nucleotide polymorphisms (SNPs) in 130 sister pairs (96 full sibs and 34 half sibs) who had DZ twins. Two, three and five SNP haplotypes differed in frequency between twinning mothers and those without a history of twinning (from P= 0.006 to 3.03e‐06 for two SNP and three SNP haplotypes, respectively). Twinning mothers and West African tuberculosis‐controls from a previous study shared several frequent haplotypes. Most importantly, our data are consistent with an independently reported association of PTX3 and female fertility in a sample from Ghana. Taken together, these results indicate that selective pressure on PTX3 variants that affect the innate immune response to infectious agents, could also produce the observed high incidence of DZ twinning in Gambians.
Annals of Human Genetics – Wiley
Published: Jan 1, 2012
Keywords: ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.