Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Cutlip, S. Windecker, R. Mehran, A. Boam, D. Cohen, G. Es, P. Steg, M. Morel, L. Mauri, P. Vranckx, E. Mcfadden, A. Lansky, M. Hamon, M. Krucoff, P. Serruys (2007)
Clinical End Points in Coronary Stent Trials: A Case for Standardized DefinitionsCirculation, 115
J. Werkum, A. Heestermans, A. Zomer, J. Kelder, M. Suttorp, B. Rensing, J. Koolen, B. Brueren, J. Dambrink, R. Hautvast, F. Verheugt, J. Berg (2009)
Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry.Journal of the American College of Cardiology, 53 16
P. Kuchulakanti, William Chu, R. Torguson, P. Ohlmann, S. Rha, L. Clavijo, Sang-Wook Kim, A. Bui, N. Gevorkian, Zhenyi Xue, Kimberly Smith, J. Fournadjieva, W. Suddath, L. Satler, A. Pichard, K. Kent, R. Waksman (2006)
Correlates and Long-Term Outcomes of Angiographically Proven Stent Thrombosis With Sirolimus- and Paclitaxel-Eluting StentsCirculation, 113
G. Acar, A. Doğan, A. Altınbaş, Y. Turker (2006)
Recurrent acute stent thrombosis associated with protein C and S deficienciesThe International Journal of Cardiovascular Imaging, 22
F. Airoldi, A. Colombo, N. Morici, A. Latib, J. Cosgrave, L. Buellesfeld, E. Bonizzoni, M. Carlino, U. Gerckens, C. Godino, G. Melzi, I. Michev, M. Montorfano, G. Sangiorgi, Asif Qasim, A. Chieffo, C. Briguori, E. Grube (2007)
Incidence and Predictors of Drug-Eluting Stent Thrombosis During and After Discontinuation of Thienopyridine TreatmentCirculation, 116
Duk‐Woo Park, Seong-Wook Park, Kyoung-Ha Park, Bong-Ki Lee, Young-Hak Kim, Cheol-Whan Lee, M. Hong, Jae‐Joong Kim, Seung‐Jung Park (2006)
Frequency of and risk factors for stent thrombosis after drug-eluting stent implantation during long-term follow-up.The American journal of cardiology, 98 3
I. Iakovou, T. Schmidt, E. Bonizzoni, L. Ge, G. Sangiorgi, G. Stanković, F. Airoldi, A. Chieffo, M. Montorfano, M. Carlino, I. Michev, N. Corvaja, C. Briguori, U. Gerckens, E. Grube, A. Colombo (2005)
Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents.JAMA, 293 17
B. Mahmoodi, J. Brouwer, N. Veeger, J. Meer (2008)
Hereditary Deficiency of Protein C or Protein S Confers Increased Risk of Arterial Thromboembolic Events at a Young Age: Results From a Large Family Cohort StudyCirculation, 118
M. Rinaldi, Ajay Kirtane, R. Piana, Ronald Caputo, Paul Gordon, John Lopez, H. Dauerman, Thomas Ryan, F. Kiernan, D. Cutlip, K. Ho, C. Gibson, Sabina Murphy, David Cohen (2008)
Clinical, procedural, and pharmacologic correlates of acute and subacute stent thrombosis: results of a multicenter case-control study with 145 thrombosis events.American heart journal, 155 4
J. Daemen, P. Wenaweser, K. Tsuchida, Linda Abrecht, S. Vaina, Cyrill Morger, N. Kukreja, P. Jüni, G. Sianos, G. Hellige, R. Domburg, O. Hess, E. Boersma, B. Meier, S. Windecker, P. Serruys (2007)
Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort studyThe Lancet, 369
D. Cutlip, D. Baim, K. Ho, J. Popma, A. Lansky, D. Cohen, J. Carrozza, M. Chauhan, O. Rodríguez, R. Kuntz (2001)
Stent Thrombosis in the Modern Era: A Pooled Analysis of Multicenter Coronary Stent Clinical TrialsCirculation: Journal of the American Heart Association, 103
Objective: To study the prevalence of protein C and/or protein S deficiency in patients of stent thrombosis and correlate its association with the event, if any. Background: Stent thrombosis is the Achilles heel of percutaneous coronary intervention (PCI) and has been associated with so many predisposing factors that if one analyzes all patients undergoing PCI, one or more such factors would be present in almost every patient; however, its incidence remains no more than 1–2%. We hypothesized a preexisting prothrombotic state, or tendency, in a small proportion of patients that possibly plays a key role in its occurrence. Methods: We analyzed the prothrombotic tendency of individual patients by studying protein C and protein S levels. Thirteen patients presenting with stent thrombosis and 24 age‐ and sex‐matched controls were studied. Results: Protein S was found to be deficient in 11 of 13 patients (84.6%) of stent thrombosis and in only 4 of 24 patients (16.7%) in matched controls (P < 0.001), while protein C was found deficient in 2 of 12 patients (16.7%) of stent thrombosis, and 1 of 24 patients (4.2%) in matched controls (P = 0.25) and either protein C or protein S was deficient in 11 of 13 (84.6%) of stent thrombosis and 5 of 24 (20.8%) controls (P = <0.001). Low protein S levels were strongly associated with stent thrombosis (odds ratio 3.04, 95% confidence interval 1.34–4.7) with sensitivity 0.73 and specificity of 0.91. Conclusions: Protein S deficiency is strongly correlated to the occurrence of stent thrombosis, a fact that has hitherto not been recognized and needs further evaluation. (J Interven Cardiol 2010;23:560–564)
Journal of Interventional Cardiology – Wiley
Published: Dec 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.