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Prognostic impact of intensive statin therapy on N‐terminal pro‐BNP level in non‐ST‐segment elevation acute myocardial infarction patients

Prognostic impact of intensive statin therapy on N‐terminal pro‐BNP level in non‐ST‐segment... INTRODUCTIONInflammatory processes are included in all states of atherosclerotic disease progression and are literally important for the initiation of acute coronary syndromes (ACSs). Accordingly, data from randomized controlled trials had reported that intensive lipid lowering with statins leads to additional clinical benefits in the same clinical settings. Statins (competitive inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase) are associated with marked risk reduction in patients with coronary artery disease (CAD). owing to their lipid lowering effect and the pleiotropic characteristics they exhibit, both in vivo and in vitro It has been shown that this class of drugs decreases reactive oxygen species generation, limits smooth muscle cells proliferation, has anti‐thrombotic and anti‐inflammatory effects, augments the production of nitric oxide in endothelial cells and stabilizes vulnerable atherosclerotic plaques. Additional non‐lipid dependent merits include inhibition of neurohormonal mechanisms (eg, renin‐angiotensin system), attenuation of ventricular remodeling (eg, altering matrix metalloproteinase activity and controlling fibrosis), decreasing rate of myocardial necrosis and augmentation of neoangiogenesis. These different mechanisms of action contribute to limitation of infarct area size and better left ventricle (LV) systolic function. B‐type natriuretic peptide (BNP) is a neurohormone (32‐amino acids) that is synthesized in the form of pre‐pro BNP, which is cleaved producing pro‐BNP, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interventional Cardiology Wiley

Prognostic impact of intensive statin therapy on N‐terminal pro‐BNP level in non‐ST‐segment elevation acute myocardial infarction patients

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References (52)

Publisher
Wiley
Copyright
© 2017 Wiley Periodicals, Inc.
ISSN
0896-4327
eISSN
1540-8183
DOI
10.1111/joic.12427
pmid
28812321
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONInflammatory processes are included in all states of atherosclerotic disease progression and are literally important for the initiation of acute coronary syndromes (ACSs). Accordingly, data from randomized controlled trials had reported that intensive lipid lowering with statins leads to additional clinical benefits in the same clinical settings. Statins (competitive inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase) are associated with marked risk reduction in patients with coronary artery disease (CAD). owing to their lipid lowering effect and the pleiotropic characteristics they exhibit, both in vivo and in vitro It has been shown that this class of drugs decreases reactive oxygen species generation, limits smooth muscle cells proliferation, has anti‐thrombotic and anti‐inflammatory effects, augments the production of nitric oxide in endothelial cells and stabilizes vulnerable atherosclerotic plaques. Additional non‐lipid dependent merits include inhibition of neurohormonal mechanisms (eg, renin‐angiotensin system), attenuation of ventricular remodeling (eg, altering matrix metalloproteinase activity and controlling fibrosis), decreasing rate of myocardial necrosis and augmentation of neoangiogenesis. These different mechanisms of action contribute to limitation of infarct area size and better left ventricle (LV) systolic function. B‐type natriuretic peptide (BNP) is a neurohormone (32‐amino acids) that is synthesized in the form of pre‐pro BNP, which is cleaved producing pro‐BNP,

Journal

Journal of Interventional CardiologyWiley

Published: Jan 1, 2017

Keywords: ; ;

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