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Preparation of Nanosized CoHCF Modified Electrode and Its Application to Electroanalysis of Hemoglobin

Preparation of Nanosized CoHCF Modified Electrode and Its Application to Electroanalysis of... A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis‐electrochemical determination (FIA‐ECD) system. The peak current was a linear function of concentrations in the range from 2.5×10‐8 to 5.0×10‐6 mol/L for Hb, with detection limit of 1.4×10‐8 mol/L. The FIA‐ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample‐consumption. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chinese Journal of Chemistry Wiley

Preparation of Nanosized CoHCF Modified Electrode and Its Application to Electroanalysis of Hemoglobin

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References (20)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1001-604X
eISSN
1614-7065
DOI
10.1002/cjoc.200590983
Publisher site
See Article on Publisher Site

Abstract

A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis‐electrochemical determination (FIA‐ECD) system. The peak current was a linear function of concentrations in the range from 2.5×10‐8 to 5.0×10‐6 mol/L for Hb, with detection limit of 1.4×10‐8 mol/L. The FIA‐ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample‐consumption.

Journal

Chinese Journal of ChemistryWiley

Published: Aug 1, 2005

Keywords: ; ; ; ;

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