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Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort

Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort IntroductionAutism spectrum disorder (ASD) is characterized by deficits in social interaction or communication and repetitive behavior or stereotypical interests. ASD is increasingly common, with a prevalence of 1 in 68 children (1 in 42 boys and 1 in 189 girls) as of 2012 [Christensen et al., ]. ASD is phenotypically and etiologically heterogeneous, with evidence for both genetic and environmental contributions to disease risk [Hallmayer et al., ; Persico & Napolioni, ; Sandin et al., ]. Converging evidence points to the prenatal period as a time where environmental exposures are most likely to influence ASD risk [Rodier, Ingram, Tisdale, Nelson, & Romano, ; Rice & Barone, ; Schlotz & Phillips, ; Barouki, Gluckman, Grandjean, Hanson, & Heindel, ; Marques, O'connor, Roth, Susser, & Bjorke‐Monsen, ; Lyall, Schmidt, & Hertz‐Picciotto, ; Stoner et al., ]. Identification of modifiable ASD risk factors can lead to preventative intervention strategies that may reduce overall ASD burden. Studies to examine a broad range of environmental risk factors for ASD during this critical time window are now emerging.There is a growing body of evidence suggesting prenatal exposure to maternal immune activation (MIA) and/or systemic inflammation increases the risk of many different types of neurodevelopmental disorders http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort

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References (46)

Publisher
Wiley
Copyright
© 2017 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1841
pmid
28799289
Publisher site
See Article on Publisher Site

Abstract

IntroductionAutism spectrum disorder (ASD) is characterized by deficits in social interaction or communication and repetitive behavior or stereotypical interests. ASD is increasingly common, with a prevalence of 1 in 68 children (1 in 42 boys and 1 in 189 girls) as of 2012 [Christensen et al., ]. ASD is phenotypically and etiologically heterogeneous, with evidence for both genetic and environmental contributions to disease risk [Hallmayer et al., ; Persico & Napolioni, ; Sandin et al., ]. Converging evidence points to the prenatal period as a time where environmental exposures are most likely to influence ASD risk [Rodier, Ingram, Tisdale, Nelson, & Romano, ; Rice & Barone, ; Schlotz & Phillips, ; Barouki, Gluckman, Grandjean, Hanson, & Heindel, ; Marques, O'connor, Roth, Susser, & Bjorke‐Monsen, ; Lyall, Schmidt, & Hertz‐Picciotto, ; Stoner et al., ]. Identification of modifiable ASD risk factors can lead to preventative intervention strategies that may reduce overall ASD burden. Studies to examine a broad range of environmental risk factors for ASD during this critical time window are now emerging.There is a growing body of evidence suggesting prenatal exposure to maternal immune activation (MIA) and/or systemic inflammation increases the risk of many different types of neurodevelopmental disorders

Journal

Autism Research – Wiley

Published: Jan 1, 2017

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