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Porcine red blood cells as a source of blood transfusion in humans

Porcine red blood cells as a source of blood transfusion in humans Eleven million blood transfusions utilizing packed red blood cells (RBCs) are administered in the USA each year [ 1 ] to approximately 4 million recipients. The national blood supply, however, is inadequate, and it is estimated to be a quarter of a million units less than the optimum required. This shortage persists despite the fact that some states, such as New York, import blood from abroad. Elective surgeries sometimes need to be postponed, particularly during the summer months, when the supply of donated blood is reduced. Not only is human blood a scarce resource, it has become a potential risk to the recipient. Despite time‐consuming and expensive viral screening processes, donated human blood is not considered to be 100% safe. Hepatitis C and HIV, although transmitted rarely, remain potential problems [ 2 ]. More recently, because of concerns relating to the increasing incidence of new variant Creutzfeldt‐Jacob disease in Europe, eligibility for blood donation has been made more restrictive by the Food and Drug Administration. Subjects who have been resident in the UK or in Europe for certain periods of time may be prevented from donating blood in the USA. In Europe, there is concern that there will http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Porcine red blood cells as a source of blood transfusion in humans

Cooper, David K.C.
Xenotransplantation , Volume 10 (5) – Sep 1, 2003
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References (41)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1034/j.1399-3089.2003.00092.x
Publisher site
See Article on Publisher Site

Abstract

Eleven million blood transfusions utilizing packed red blood cells (RBCs) are administered in the USA each year [ 1 ] to approximately 4 million recipients. The national blood supply, however, is inadequate, and it is estimated to be a quarter of a million units less than the optimum required. This shortage persists despite the fact that some states, such as New York, import blood from abroad. Elective surgeries sometimes need to be postponed, particularly during the summer months, when the supply of donated blood is reduced. Not only is human blood a scarce resource, it has become a potential risk to the recipient. Despite time‐consuming and expensive viral screening processes, donated human blood is not considered to be 100% safe. Hepatitis C and HIV, although transmitted rarely, remain potential problems [ 2 ]. More recently, because of concerns relating to the increasing incidence of new variant Creutzfeldt‐Jacob disease in Europe, eligibility for blood donation has been made more restrictive by the Food and Drug Administration. Subjects who have been resident in the UK or in Europe for certain periods of time may be prevented from donating blood in the USA. In Europe, there is concern that there will

Journal

Xenotransplantation – Wiley

Published: Sep 1, 2003

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