Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Tishkoff, K. Kidd (2004)
Implications of biogeography of human populations for 'race' and medicineNature Genetics, 36 Suppl 1
S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M. Ferreira, David Bender, J. Maller, P. Sklar, P. Bakker, M. Daly, P. Sham (2007)
PLINK: a tool set for whole-genome association and population-based linkage analyses.American journal of human genetics, 81 3
Hu Zhang, D. Massey, M. Tremelling, M. Parkes (2008)
Genetics of inflammatory bowel disease: clues to pathogenesis.British medical bulletin, 87
S. Kugathasan, R. Baldassano, J. Bradfield, P. Sleiman, M. Imieliński, S. Guthery, S. Cucchiara, Cecilia Kim, E. Frackelton, K. Annaiah, J. Glessner, Erin Santa, T. Willson, Andrew Eckert, Erin Bonkowski, Julie Shaner, Ryan Smith, F. Otieno, N. Peterson, D. Abrams, R. Chiavacci, R. Grundmeier, P. Mamula, G. Tomer, D. Piccoli, D. Monos, V. Annese, L. Denson, S. Grant, H. Hakonarson (2008)
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel diseaseNature Genetics, 40
Q. Guo, B. Xia, Yi Jiang, Yan-yan Qu, Jing Li (2004)
NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality.World journal of gastroenterology, 10 7
M. Olivier (2003)
A haplotype map of the human genome.Nature, 437 7063
D. Schaid, S. Sommer (1993)
Genotype relative risks: methods for design and analysis of candidate-gene association studies.American journal of human genetics, 53 5
Hiroki Oota, A. Pakstis, B. Bonné-Tamir, D. Goldman, E. Grigorenko, S. Kajuna, N. Karoma, Selemani Kungulilo, R. Lu, K. Odunsi, F. Okonofua, O. Zhukova, J. Kidd, K. Kidd (2004)
The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombinationAnnals of Human Genetics, 68
C. Tysk, E. Lindberg, G. Järnerot, B. Floderus-Myrhed (1988)
Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.Gut, 29
P. Dubois, D. Heel (2008)
New susceptibility genes for ulcerative colitisNature Genetics, 40
Y. Ogura, D. Bonen, N. Inohara, D. Nicolae, Felicia Chen, Richard Ramos, Heidi Britton, Thomas Moran, Reda Karaliuskas, R. Duerr, J. Achkar, S. Brant, T. Bayless, B. Kirschner, S. Hanauer, G. Núñez, Judy Cho (2001)
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseNature, 411
S. Fisher, M. Tremelling, C. Anderson, R. Gwilliam, S. Bumpstead, N. Prescott, E. Nimmo, D. Massey, C. Berzuini, Christopher Johnson, J. Barrett, Fraser Cummings, H. Drummond, C. Lees, Clive Onnie, Catherine Hanson, K. Błaszczyk, M. Inouye, Philip Ewels, Radhi Ravindrarajah, Andrew Keniry, S. Hunt, M. Carter, Nick Watkins, W. Ouwehand, C. Lewis, L. Cardon, A. Lobo, A. Forbes, J. Sanderson, D. Jewell, J. Mansfield, P. Deloukas, C. Mathew, M. Parkes, J. Satsangi (2008)
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseNature Genetics, 40
S. Myles, D. Davison, J. Barrett, M. Stoneking, N. Timpson (2008)
Bmc Medical Genomics Worldwide Population Differentiation at Disease-associated Snps
K. Asakura, Y. Nishiwaki, N. Inoue, T. Hibi, Mamoru Watanabe, T. Takebayashi (2009)
Prevalence of ulcerative colitis and Crohn’s disease in JapanJournal of Gastroenterology, 44
A. Franke, T. Balschun, T. Karlsen, Jurgita Šventoraitytė, S. Nikolaus, Gabriele Mayr, F. Domingues, M. Albrecht, M. Nothnagel, D. Ellinghaus, C. Sina, Clive Onnie, R. Weersma, P. Stokkers, C. Wijmenga, M. Gazouli, D. Strachan, W. McArdle, S. Vermeire, P. Rutgeerts, P. Rosenstiel, M. Krawczak, M. Vatn, C. Mathew, S. Schreiber (2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibilityNature Genetics, 40
K. Frazer, D. Ballinger, D. Cox, D. Hinds, L. Stuve, R. Gibbs, J. Belmont, A. Boudreau, P. Hardenbol, S. Leal, S. Pasternak, D. Wheeler, T. Willis, F. Yu, Huanming Yang, Changqing Zeng, Yang Gao, Haoran Hu, Weitao Hu, Chaohua Li, Wei Lin, Siqi Liu, Hao Pan, Xiaoli Tang, Jian Wang, Wei Wang, Jun Yu, Bo Zhang, Qingrun Zhang, Hongbin Zhao, Hui-Ping Zhao, Jun Zhou, S. Gabriel, Rachel Barry, B. Blumenstiel, Amy Camargo, M. Defelice, M. Faggart, Marie-Anne Goyette, Supriya Gupta, Jamie Moore, Huy Nguyen, R. Onofrio, Melissa Parkin, J. Roy, E. Stahl, E. Winchester, L. Ziaugra, D. Altshuler, Yan Shen, Zhijian Yao, Wei Huang, X. Chu, Yungang He, Li Jin, Yangfan Liu, Yayun Shen, Weiwei Sun, Haifeng Wang, Yi Wang, Ying Wang, Xiao-yan Xiong, Liang Xu, M. Waye, S. Tsui, H. Xue, J. Wong, L. Galver, Jian-Bing Fan, K. Gunderson, S. Murray, A. Oliphant, M. Chee, A. Montpetit, F. Chagnon, Vincent Ferretti, M. Leboeuf, J. Olivier, M. Phillips, Stéphanie Roumy, C. Sallée, A. Verner, T. Hudson, P. Kwok, Dongmei Cai, D. Koboldt, Raymond Miller, L. Pawlikowska, P. Taillon-Miller, M. Xiao, L. Tsui, W. Mak, You-Qiang Song, P. Tam, Yusuke Nakamura, T. Kawaguchi, T. Kitamoto, Takashi Morizono, A. Nagashima, Y. Ohnishi, A. Sekine, Toshihiro Tanaka, T. Tsunoda, P. Deloukas, C. Bird, Marcos Delgado, E. Dermitzakis, R. Gwilliam, S. Hunt, J. Morrison, Don Powell, B. Stranger, P. Whittaker, D. Bentley, M. Daly, P. Bakker, J. Barrett, Y. Chretien, J. Maller, S. Mccarroll, N. Patterson, I. Pe’er, A. Price, S. Purcell, D. Richter, Pardis Sabeti, R. Saxena, S. Schaffner, P. Sham, P. Varilly, Lincoln Stein, Lalitha Krishnan, A. Smith, M. Tello-Ruiz, Gudmundur Thorisson, A. Chakravarti, Peter Chen, D. Cutler, C. Kashuk, Shin Lin, G. Abecasis, W. Guan, Yun Li, Heather Munro, Zhaohui Qin, D. Thomas, G. McVean, A. Auton, L. Bottolo, Niall Cardin, S. Eyheramendy, C. Freeman, J. Marchini, S. Myers, C. Spencer, M. Stephens, P. Donnelly, L. Cardon, G. Clarke, David Evans, A. Morris, B. Weir, J. Mullikin, S. Sherry, M. Feolo, Andrew Skol, Houcan Zhang, I. Matsuda, Y. Fukushima, D. Macer, Eiko Suda, C. Rotimi, C. Adebamowo, I. Ajayi, Toyin Aniagwu, P. Marshall, C. Nkwodimmah, C. Royal, M. Leppert, M. Dixon, A. Peiffer, Renzong Qiu, A. Kent, Kazuto Kato, N. Niikawa, I. Adewole, B. Knoppers, Morris Foster, E. Clayton, Jessica Watkin, D. Muzny, L. Nazareth, E. Sodergren, G. Weinstock, I. Yakub, B. Birren, R. Wilson, L. Fulton, J. Rogers, J. Burton, N. Carter, C. Clee, M. Griffiths, Matthew Jones, K. McLay, R. Plumb, M. Ross, S. Sims, D. Willey, Zhu Chen, Hua Han, L. Kang, M. Godbout, J. Wallenburg, P. L'Archevêque, G. Bellemare, Koji Saeki, Hongguang Wang, Daochang An, Hongbo Fu, Qing Li, Zhen Wang, Ren-hao Wang, A. Holden, L. Brooks, J. Mcewen, M. Guyer, V. Wang, Jane Peterson, Michael Shi, J. Spiegel, L. Sung, Lynn Zacharia, F. Collins, Karen Kennedy, Ruth Jamieson, J. Stewart (2007)
A second generation human haplotype map of over 3.1 million SNPsNature, 449
S. Yoshitake, A. Kimura, M. Okada, T. Yao, T. Sasazuki (1999)
HLA class II alleles in Japanese patients with inflammatory bowel disease.Tissue antigens, 53 4 Pt 1
J. Barrett, S. Hansoul, D. Nicolae, Judy Cho, R. Duerr, J. Rioux, J. Rioux, S. Brant, M. Silverberg, K. Taylor, M. Barmada, A. Bitton, T. Dassopoulos, L. Datta, Todd Green, A. Griffiths, E. Kistner, M. Murtha, M. Regueiro, J. Rotter, L. Schumm, A. Steinhart, S. Targan, R. Xavier, C. Libioulle, C. Sandor, M. Lathrop, J. Belaiche, O. Dewit, I. Gut, S. Heath, D. Laukens, M. Mni, P. Rutgeerts, A. Gossum, D. Zélénika, D. Franchimont, J. Hugot, M. Vos, S. Vermeire, E. Louis, L. Cardon, C. Anderson, H. Drummond, E. Nimmo, T. Ahmad, N. Prescott, Clive Onnie, S. Fisher, J. Marchini, J. Ghori, S. Bumpstead, R. Gwilliam, M. Tremelling, P. Deloukas, J. Mansfield, D. Jewell, J. Satsangi, C. Mathew, M. Parkes, M. Georges, M. Daly, M. Daly (2008)
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseNature Genetics, 40
M. Orholm, P. Munkholm, E. Langholz, O. Nielsen, T. Sørensen, V. Binder (1991)
Familial occurrence of inflammatory bowel disease.The New England journal of medicine, 324 2
D. Gaya, R. Russell, E. Nimmo, J. Satsangi (2006)
New genes in inflammatory bowel disease: lessons for complex diseases?The Lancet, 367
E. Szigethy, L. McLafferty, A. Goyal (2011)
Inflammatory bowel disease.Pediatric clinics of North America, 58 4
K. Mossman (2008)
The Wellcome Trust Case Control Consortium, U.K.Scientific American, 298
E. Emison, A. McCallion, C. Kashuk, R. Bush, E. Grice, Shin Lin, M. Portnoy, D. Cutler, E. Green, A. Chakravarti (2005)
A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease riskNature, 434
J. Rioux, J. Rioux, R. Xavier, K. Taylor, M. Silverberg, P. Goyette, A. Huett, Todd Green, Petric Kuballa, M. Barmada, L. Datta, Y. Shugart, A. Griffiths, S. Targan, A. Ippoliti, E. Bernard, L. Mei, D. Nicolae, M. Regueiro, L. Schumm, A. Steinhart, J. Rotter, R. Duerr, Judy Cho, M. Daly, M. Daly, S. Brant (2007)
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisNature Genetics, 39
J. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J. Cézard, J. Belaiche, S. Almér, C. Tysk, C. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J. Colombel, M. Sahbatou, G. Thomas (2001)
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseNature, 411
M. Zaahl, T. Winter, L. Warnich, M. Kotze (2005)
Analysis of the three common mutations in the CARD15 gene (R702W, G908R and 1007fs) in South African colored patients with inflammatory bowel disease.Molecular and cellular probes, 19 4
P. Burton, D. Clayton, L. Cardon, N. Craddock, P. Deloukas, A. Duncanson, D. Kwiatkowski, M. McCarthy, W. Ouwehand, N. Samani, J. Todd, P. Donnelly, J. Barrett, D. Davison, D. Easton, David Evans, H. Leung, J. Marchini, A. Morris, C. Spencer, M. Tobin, A. Attwood, J. Boorman, B. Cant, Ursula Everson, Judith Hussey, J. Jolley, A. Knight, K. Koch, Elizabeth Meech, S. Nutland, C. Prowse, H. Stevens, N. Taylor, G. Walters, N. Walker, N. Watkins, T. Winzer, Richard Jones, W. McArdle, S. Ring, D. Strachan, M. Pembrey, G. Breen, D. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. Green, D. Grozeva, M. Hamshere, P. Holmans, I. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. O’Donovan, M. Owen, D. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. Young, I. Ferrier, S. Ball, A. Balmforth, J. Barrett, D. Bishop, M. Iles, A. Maqbool, N. Yuldasheva, A. Hall, P. Braund, R. Dixon, M. Mangino, S. Stevens, J. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. Lees, E. Nimmo, J. Satsangi, S. Fisher, A. Forbes, C. Lewis, Clive Onnie, N. Prescott, J. Sanderson, C. Mathew, J. Barbour, M. Mohiuddin, C. Todhunter, J. Mansfield, T. Ahmad, Fraser Cummings, D. Jewell, J. Webster, Morris Brown, G. Lathrop, J. Connell, A. Dominiczak, C. Marcano, B. Burke, R. Dobson, J. Gungadoo, Kate Lee, P. Munroe, S. Newhouse, Abiodun Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. Bruce, Hannah Donovan, S. Eyre, Paul Gilbert, S. Hider, A. Hinks, S. John, C. Potter, A. Silman, D. Symmons, W. Thomson, Jane Worthington, D. Dunger, B. Widmer, T. Frayling, R. Freathy, H. Lango, J. Perry, B. Shields, M. Weedon, A. Hattersley, G. Hitman, M. Walker, K. Elliott, C. Groves, C. Lindgren, N. Rayner, N. Timpson, E. Zeggini, M. Newport, G. Sirugo, Emily Lyons, F. Vannberg, A. Hill, L. Bradbury, C. Farrar, J. Pointon, Paul Wordsworth, M. Brown, J. Franklyn, J. Heward, M. Simmonds, S. Gough, S. Seal, M. Stratton, N. Rahman, M. Ban, A. Goris, S. Sawcer, Alastair Compston, D. Conway, M. Jallow, K. Rockett, S. Bumpstead, Amy Chaney, K. Downes, Mohammed Ghori, R. Gwilliam, S. Hunt, M. Inouye, Andrew Keniry, E. King, R. McGinnis, Simon Potter, R. Ravindrarajah, P. Whittaker, Claire Widden, D. Withers, Niall Cardin, T. Ferreira, Joanne Pereira-Gale, Ingileif Hallgrímsdóttir, Bryan Howie, Z. Su, Y. Teo, Damjan Vukcevic, D. Bentley, A. Compston (2007)
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 447
S. Myles, D. Davison, J. Barrett, M. Stoneking, N. Timpson (2008)
Worldwide population differentiation at disease‐associated SNPs, 1
M. S. Silverberg, J. H. Cho, J. D. Rioux, D. P. Mcgovern, J. Wu, V. Annese, J. P. Achkar, P. Goyette, R. Scott, W. Xu, M. M. Barmada, L. Klei, M. J. Daly, C. Abraham, T. M. Bayless, F. Bossa, A. M. Griffiths, A. F. Ippoliti, R. G. Lahaie, A. Latiano, P. Pare, D. D. Proctor, M. D. Regueiro, A. H. Steinhart, S. R. Targan, L. P. Schumm, E. O. Kistner, A. T. Lee, P. K. Gregersen, J. I. Rotter, S. R. Brant, K. D. Taylor, K. Roeder, R. H. Duerr (2009)
Ulcerative colitis‐risk loci on chromosomes 1p36 and 12q15 found by genome‐wide association study, 41
C. Libioulle, E. Louis, S. Hansoul, C. Sandor, F. Farnir, D. Franchimont, S. Vermeire, O. Dewit, M. Vos, A. Dixon, B. Demarche, I. Gut, S. Heath, M. Foglio, L. Liang, D. Laukens, M. Mni, D. Zélénika, A. Gossum, P. Rutgeerts, J. Belaiche, M. Lathrop, M. Georges (2007)
Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4PLoS Genetics, 3
D. Altshuler, M. Daly, E. Lander (2008)
Genetic Mapping in Human DiseaseScience, 322
K. Yamazaki, D. McGovern, J. Ragoussis, M. Paolucci, H. Butler, D. Jewell, L. Cardon, M. Takazoe, Torao Tanaka, T. Ichimori, S. Saito, A. Sekine, A. Iida, A. Takahashi, T. Tsunoda, M. Lathrop, Yusuke Nakamura (2005)
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease.Human molecular genetics, 14 22
J. Raelson, R. Little, A. Ruether, Hélène Fournier, B. Paquin, P. Eerdewegh, W. Bradley, P. Croteau, Quynh Nguyen-Huu, J. Segal, S. Debrus, R. Allard, P. Rosenstiel, A. Franke, G. Jacobs, S. Nikolaus, Jean-Michel Vidal, P. Szego, N. Laplante, H. Clark, R. Paulussen, J. Hooper, T. Keith, A. Belouchi, S. Schreiber (2007)
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease lociProceedings of the National Academy of Sciences, 104
Y. Kakuta, Y. Kinouchi, K. Negoro, S. Takahashi, T. Shimosegawa (2006)
Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel diseaseGut, 55
Jun Li, D. Absher, Hua Tang, Audrey Southwick, A. Casto, Sohini Ramachandran, H. Cann, G. Barsh, M. Feldman, L. Cavalli-Sforza, R. Myers
Supporting Online Material Materials and Methods Figs. S1 to S3 Tables S1 to S5 References Worldwide Human Relationships Inferred from Genome-wide Patterns of Variation
K. Yamazaki, Y. Onouchi, M. Takazoe, M. Kubo, Yusuke Nakamura, A. Hata (2007)
Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patientsJournal of Human Genetics, 52
K. Yamazaki, M. Takazoe, Torao Tanaka, T. Ichimori, S. Saito, A. Iida, Y. Onouchi, A. Hata, Yusuke Nakamura (2004)
Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn diseaseJournal of Human Genetics, 49
(2009)
Ulcerative colitis-risk loci on chromosomes
M. Parkes, J. Barrett, N. Prescott, M. Tremelling, C. Anderson, S. Fisher, R. Roberts, E. Nimmo, Fraser Cummings, D. Soars, H. Drummond, C. Lees, S. Khawaja, R. Bagnall, D. Burke, Catherine Todhunter, Tariq Ahmad, Clive Onnie, W. McArdle, D. Strachan, G. Bethel, C. Bryan, C. Lewis, P. Deloukas, A. Forbes, J. Sanderson, D. Jewell, J. Satsangi, J. Mansfield, L. Cardon, C. Mathew (2007)
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityNature Genetics, 39
A. Franke, T. Balschun, T. Karlsen, J. Hedderich, Sandra May, T. Lu, D. Schuldt, S. Nikolaus, P. Rosenstiel, M. Krawczak, S. Schreiber (2008)
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitisNature Genetics, 40
J. Hampe, A. Franke, P. Rosenstiel, A. Till, M. Teuber, K. Huse, M. Albrecht, Gabriele Mayr, F. Vega, Jason Briggs, Simone Günther, N. Prescott, Clive Onnie, R. Häsler, B. Sipos, U. Fölsch, Thomas Lengauer, M. Platzer, C. Mathew, M. Krawczak, S. Schreiber (2007)
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Nature Genetics, 39
D. Podolsky (1991)
Inflammatory bowel disease (Second of two parts)The New England Journal of Medicine, 325
C. Mathew (2008)
New links to the pathogenesis of Crohn disease provided by genome-wide association scansNature Reviews Genetics, 9
R. Xavier, D. Podolsky (2007)
Unravelling the pathogenesis of inflammatory bowel diseaseNature, 448
J. Z. Li, D. M. Absher, H. Tang, A. M. Southwick, A. M. Casto, S. Ramachandran, H. M. Cann, G. S. Barsh, M. Feldman, L. L. Cavalli‐Sforza, R. M. Myers (2008)
Worldwide human relationships inferred from genome‐wide patterns of variation, 319
Senem Özen, Ü. Daǧlı, M. Kılıç, M. Törüner, Y. Çelik, M. Özkan, I. Soykan, H. Çetinkaya, A. Ülker, A. Özden, A. Bozdayi (2006)
NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel diseaseJournal of Gastroenterology, 41
P. Croucher, S. Mascheretti, J. Hampe, K. Huse, H. Frenzel, M. Stoll, T. Lu, S. Nikolaus, Suk-Kyun Yang, M. Krawczak, W. Kim, S. Schreiber (2003)
Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populationsEuropean Journal of Human Genetics, 11
V. Peltekova, R. Wintle, L. Rubin, C. Amos, Qiqing Huang, X. Gu, B. Newman, M. Oene, D. Cescon, G. Greenberg, A. Griffiths, P. George-Hyslop, K. Siminovitch (2004)
Functional variants of OCTN cation transporter genes are associated with Crohn diseaseNature Genetics, 36
K. Yamazaki, M. Takazoe, Torao Tanaka, Toshiki Kazumori, Yusuke Nakamura (2002)
Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's diseaseJournal of Human Genetics, 47
E. Loftus (2004)
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.Gastroenterology, 126 6
S. Tishkoff, E. Dietzsch, W. Speed, A. Pakstis, J. Kidd, K. Cheung, B. Bonné-Tamir, A. Santachiara‐Benerecetti, P. Moral, M. Krings, S. Pääbo, E. Watson, N. Risch, T. Jenkins, K. Kidd (1996)
Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human OriginsScience, 271
Y. Yamaguchi-Kabata, Kazuyuki Nakazono, A. Takahashi, S. Saito, N. Hosono, M. Kubo, Yusuke Nakamura, N. Kamatani (2008)
Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.American journal of human genetics, 83 4
I. Hilmi, Ym Tan, K. Goh (2006)
Crohn's disease in adults: observations in a multiracial Asian population.World journal of gastroenterology, 12 9
R. Duerr, K. Taylor, S. Brant, S. Brant, J. Rioux, J. Rioux, M. Silverberg, M. Daly, M. Daly, A. Steinhart, C. Abraham, M. Regueiro, A. Griffiths, T. Dassopoulos, A. Bitton, Huiying Yang, S. Targan, L. Datta, E. Kistner, L. Schumm, Annette Lee, P. Gregersen, M. Barmada, J. Rotter, D. Nicolae, Judy Cho (2006)
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease GeneScience, 314
K. Yamazaki, A. Takahashi, Masakazu Takazoe, M. Kubo, Y. Onouchi, Akihiro Fujino, Naoyuki Kamatani, Yusuke Nakamura, Akira Hata (2008)
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn’s disease in Japanese patientsGut, 58
Crohn's disease (CD), a type of chronic inflammatory bowel disease (IBD), is commonly found in European and East Asian countries. The calculated heritability of CD appears to be higher than that of ulcerative colitis (UC), another type of IBD. Recent genome‐wide association studies (GWAS) have identified more than thirty CD‐associated genes/regions in the European population. In the East Asian population, however, a clear association between CD and an associated gene has only been detected with TNFSF15. In order to determine if CD susceptibility differs geographically, nine SNPs from seven of the European CD‐associated genomic regions were selected for analysis. The genotype frequencies for these SNPs were compared among the 380 collected Japanese samples, which consisted of 212 IBD cases and 168 controls. We detected a significant association of both CD and UC with only the TNFSF15 gene. Analysis by the modified genotype relative risk test (mGRR) indicated that the risk allele of TNFSF15 is dominant for CD, but is recessive for UC. These results suggest that CD and UC susceptibility differs between the Japanese and European populations. Furthermore, it is also likely that CD and UC share a causative factor which exhibits a different dominant/recessive relative risk in the Japanese population.
Annals of Human Genetics – Wiley
Published: Jan 1, 2010
Keywords: ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.