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Polyreactive antibodies and their association with xenotransplantation

Polyreactive antibodies and their association with xenotransplantation A wide range of studies, described briefly in this review, suggests that xenoreactive antibodies can be divided into at least two classes: anti‐carbohydrate and polyreactive. Taken together, these studies point to the conclusion that, although there are relatively few antigen binding sites for polyreactive antibodies on cultured porcine cells, there are more polyreactive, xenoreactive antibodies than anti‐Gal α 1‐3Gal antibodies in the blood of normal individuals. Thus, although the predominant xengeneic antigen is Gal α 1‐3Gal, the predominant xenoreactive antibody is likely polyreactive. Here, the data underlying this conclusion are briefly reviewed. A polyreactive antibody can be defined as an antibody able to bind a definable, restricted set of antigens, not just a single antigen [ 1–7 ]. As one example, Moller's group examined the specificity of a monoclonal antibody that bound to a number of seemingly unrelated molecules including cellulose, nucleic acids, bovine thyroglobulin, transferrin, and cytochrome c [ 8 ]. They found that the antibody bound, at least in part, to the carbohydrate on bovine thyroglobulin, but not to Gal α 1‐3Gal. Polyreactive antibodies are thought to provide the primary defense against pathogens in primitive invertebrates [ 9 ] and perhaps provide some defense in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Polyreactive antibodies and their association with xenotransplantation

Xenotransplantation , Volume 10 (6) – Nov 1, 2003

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References (20)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1034/j.1399-3089.2003.00083.x
Publisher site
See Article on Publisher Site

Abstract

A wide range of studies, described briefly in this review, suggests that xenoreactive antibodies can be divided into at least two classes: anti‐carbohydrate and polyreactive. Taken together, these studies point to the conclusion that, although there are relatively few antigen binding sites for polyreactive antibodies on cultured porcine cells, there are more polyreactive, xenoreactive antibodies than anti‐Gal α 1‐3Gal antibodies in the blood of normal individuals. Thus, although the predominant xengeneic antigen is Gal α 1‐3Gal, the predominant xenoreactive antibody is likely polyreactive. Here, the data underlying this conclusion are briefly reviewed. A polyreactive antibody can be defined as an antibody able to bind a definable, restricted set of antigens, not just a single antigen [ 1–7 ]. As one example, Moller's group examined the specificity of a monoclonal antibody that bound to a number of seemingly unrelated molecules including cellulose, nucleic acids, bovine thyroglobulin, transferrin, and cytochrome c [ 8 ]. They found that the antibody bound, at least in part, to the carbohydrate on bovine thyroglobulin, but not to Gal α 1‐3Gal. Polyreactive antibodies are thought to provide the primary defense against pathogens in primitive invertebrates [ 9 ] and perhaps provide some defense in the

Journal

XenotransplantationWiley

Published: Nov 1, 2003

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