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Physiological aspects of xenotransplantation, 2001

Physiological aspects of xenotransplantation, 2001 The evolution of mammals has resulted in increasing functional specialization. Most physiological incompatibilities and species‐specific differences between mammal species remain unknown. Targeted investigations indicate that even individuals of one species or strain may demonstrate slight genetically based metabolic differences. This is particularly true for widely divergent species, which show significant and multiple incompatibilities because of their evolutionary development. This is not restricted to differences in molecules, hormones, enzymes and their receptors, but also to species‐specific products that will prove antigenic [ 1 ]. The question of whether xenogeneic donor organs will be physiologically compatible with the human host has therefore to be addressed: even suboptimal functioning of one or several systems may cause life‐threatening problems to the xenografted patient. The literature until the year 2000 contains 15 763 publications on xenotransplantation (XTx), of which 2484 were related primarily to the problems of rejection and immunosuppression. Some 501 publications mentioned non‐immunological barriers, but only two dealt primarily with the problems of physiology and biochemistry. In the years 2000–2001, of 245 publications on XTx, only five dealt with organ‐specific physiological problems, mainly relating to coagulation. Here, we review several papers on physiological aspects of XTx published in recent years, without http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Physiological aspects of xenotransplantation, 2001

Hammer, C.; Thein, E.
Xenotransplantation , Volume 9 (5) – Sep 1, 2002
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References (36)

Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1034/j.1399-3089.2002.02036.x
Publisher site
See Article on Publisher Site

Abstract

The evolution of mammals has resulted in increasing functional specialization. Most physiological incompatibilities and species‐specific differences between mammal species remain unknown. Targeted investigations indicate that even individuals of one species or strain may demonstrate slight genetically based metabolic differences. This is particularly true for widely divergent species, which show significant and multiple incompatibilities because of their evolutionary development. This is not restricted to differences in molecules, hormones, enzymes and their receptors, but also to species‐specific products that will prove antigenic [ 1 ]. The question of whether xenogeneic donor organs will be physiologically compatible with the human host has therefore to be addressed: even suboptimal functioning of one or several systems may cause life‐threatening problems to the xenografted patient. The literature until the year 2000 contains 15 763 publications on xenotransplantation (XTx), of which 2484 were related primarily to the problems of rejection and immunosuppression. Some 501 publications mentioned non‐immunological barriers, but only two dealt primarily with the problems of physiology and biochemistry. In the years 2000–2001, of 245 publications on XTx, only five dealt with organ‐specific physiological problems, mainly relating to coagulation. Here, we review several papers on physiological aspects of XTx published in recent years, without

Journal

Xenotransplantation – Wiley

Published: Sep 1, 2002

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