Access the full text.
Sign up today, get DeepDyve free for 14 days.
Allan Gulledge, Susanna Park, Y. Kawaguchi, G. Stuart (2007)
Heterogeneity of phasic cholinergic signaling in neocortical neurons.Journal of neurophysiology, 97 3
G. Laube, C. Seidenbecher, K. Richter, D. Dieterich, B. Hoffmann, M. Landwehr, K. Smalla, C Winter, T. Bö, G. Wolf, E. Gundelfinger, M. Kreutz (2002)
The Neuron-Specific Ca 2-Binding Protein Caldendrin : Gene Structure , Splice Isoforms , and Expression in the Rat Central Nervous System
G. Laube, C. Seidenbecher, K. Richter, D. Dieterich, B. Hoffmann, M. Landwehr, K. Smalla, C. Winter, T. Böckers, G. Wolf, E. Gundelfinger, M. Kreutz (2002)
The Neuron-Specific Ca2+-Binding Protein Caldendrin: Gene Structure, Splice Isoforms, and Expression in the Rat Central Nervous SystemMolecular and Cellular Neuroscience, 19
L. Benardo (1993)
Characterization of cholinergic and noradrenergic slow excitatory postsynaptic potentials from rat cerebral cortical neuronsNeuroscience, 53
M. Stocker, M. Krause, P. Pedarzani, M. Planck (1999)
An apamin-sensitive Ca 21 -activated K 1 current in hippocampal pyramidal neurons
A. Cole, R. Nicoll (1983)
Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells.Science, 221 4617
L. Benardo, D. Prince (1982)
Ionic mechanisms of cholinergic excitation in mammalian hippocampal pyramidal cellsBrain Research, 249
J. Power, P. Sah (2002)
Nuclear Calcium Signaling Evoked by Cholinergic Stimulation in Hippocampal CA1 Pyramidal NeuronsThe Journal of Neuroscience, 22
R. Metherate, J. Ashe (1993)
Nucleus basalis stimulation facilitates thalamocortical synaptic transmission in the rat auditory cortexSynapse, 14
L. Benardo, D. Prince (1981)
Acetylcholine induced modulation of hippocampal pyramidal neuronsBrain Research, 211
C. Seidenbecher, K. Langnaese, L. Sanmartí-Vila, T. Boeckers, K. Smalla, B. Sabel, C. Garner, E. Gundelfinger, M. Kreutz (1998)
Caldendrin, a Novel Neuronal Calcium-binding Protein Confined to the Somato-dendritic Compartment*The Journal of Biological Chemistry, 273
A. Kapur, M. Yeckel, D. Johnston (2001)
Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathwayNeuroscience, 107
A. Mcquiston, D. Madison (1999)
Nicotinic Receptor Activation Excites Distinct Subtypes of Interneurons in the Rat HippocampusThe Journal of Neuroscience, 19
J. Hounsgaard (1978)
Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampusExperimental Neurology, 62
M. Hasselmo, J. Bower (1992)
Cholinergic suppression specific to intrinsic not afferent fiber synapses in rat piriform (olfactory) cortex.Journal of neurophysiology, 67 5
C. Mu¨ller, W. Singer (1989)
Acetylcholine-induced inhibition in the cat visual cortex is mediated by a GABAergic mechanismBrain Research, 487
J. Porter, B. Cauli, K. Tsuzuki, B. Lambolez, J. Rossier, E. Audinat (1999)
Selective Excitation of Subtypes of Neocortical Interneurons by Nicotinic ReceptorsThe Journal of Neuroscience, 19
L. Benardo, D. Prince (1982)
Cholinergic excitation of mammalian hippocampal pyramidal cellsBrain Research, 249
D. McCormick, D. Prince (1986)
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.The Journal of Physiology, 375
Z. Gil, B. Connors, Y. Amitai (1997)
Differential Regulation of Neocortical Synapses by Neuromodulators and ActivityNeuron, 19
M. Wakamori, H. Hidaka, N. Akaike (1993)
Hyperpolarizing muscarinic responses of freshly dissociated rat hippocampal CA1 neurones.The Journal of Physiology, 463
K. Krnjević, R. Pumain, L. Renaud (1971)
The mechanism of excitation by acetylcholine in the cerebral cortexThe Journal of Physiology, 215
Candace Hsieh, Scott Cruikshank, R. Metherate (2000)
Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonistBrain Research, 880
M. Hasselmo, M. Cekic (1996)
Suppression of synaptic transmission may allow combination of associative feedback and self-organizing feedforward connections in the neocortexBehavioural Brain Research, 79
Traces in (A) and (C) are averages of four consecutive trials. Data in (B) and (D) are presented as mean 6 SD
K. Vogt, W. Regehr (2001)
Cholinergic Modulation of Excitatory Synaptic Transmission in the CA3 Area of the HippocampusThe Journal of Neuroscience, 21
Allan Gulledge, G. Stuart (2005)
Cholinergic Inhibition of Neocortical Pyramidal NeuronsThe Journal of Neuroscience, 25
Steven Johnson, V. Seutin (1997)
Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currentsNeuroscience Letters, 231
S. Haj-Dahmane, R. Andrade (1996)
Muscarinic Activation of a Voltage-Dependent Cation Nonselective Current in Rat Association CortexThe Journal of Neuroscience, 16
A. Mcquiston, D. Madison (1999)
Muscarinic Receptor Activity Has Multiple Effects on the Resting Membrane Potentials of CA1 Hippocampal InterneuronsThe Journal of Neuroscience, 19
F. Kimura, M. Fukuda, T. Tsumoto (1999)
Acetylcholine suppresses the spread of excitation in the visual cortex revealed by optical recording: possible differential effect depending on the source of inputEuropean Journal of Neuroscience, 11
M. Segal (1982)
Changes in neurotransmitter actions in the aged rat hippocampusNeurobiology of Aging, 3
A. Bandrowski, S. Moore, J. Ashe (2001)
Cholinergic synaptic potentials in the supragranular layers of auditory cortexSynapse, 41
R. Metherate, C. Cox, J. Ashe (1992)
Cellular bases of neocortical activation: modulation of neural oscillations by the nucleus basalis and endogenous acetylcholine, 12
H. Widmer, L. Ferrigan, C. Davies, S. Cobb (2006)
Evoked slow muscarinic acetylcholinergic synaptic potentials in rat hippocampal interneuronsHippocampus, 16
R. Valentino, R. Dingledine (1981)
Presynaptic inhibitory effect of acetylcholine in the hippocampus, 1
Acetylcholine (ACh) acts as a neurotransmitter in both the hippocampus and neocortex to facilitate learning, memory, and cognitive function. Here we show that transient muscarinic ACh receptor (mAChR) activation inhibits action potential generation in CA1, but not in CA3, pyramidal neurons via activation of an SK‐type calcium‐activated potassium conductance. Hyperpolarizing responses generated by focal ACh application near the somata of CA1 pyramidal neurons were blocked by atropine or the M1‐like mAChR antagonist pirenzepine, but not by the M2‐like mAChR antagonist methoctramine. Inhibitory cholinergic responses required intracellular calcium signaling, as evidenced by their sensitivity to depletion of internal calcium stores or internal calcium chelation. Cholinergic inhibition did not require GABAergic synaptic transmission, but was blocked by apamin, an SK channel antagonist. In contrast to inhibitory effects in CA1 neurons, ACh was primarily depolarizing, and enhanced action potential firing in CA3 pyramidal neurons. These results, when combined with recent data in neocortical neurons, suggest a functional homology in phasic cholinergic signaling in the hippocampus and neocortex whereby ACh preferentially inhibits those neurons in the lower cortical layers (CA1 and layer 5 neurons) that provide the majority of extracortical efferent projections. © 2007 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Jan 1, 2007
Keywords: ; ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.