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C. Cannings, E. Thompson, M. Skolnick (1978)
Probability functions on complex pedigreesAdvances in Applied Probability, 10
(1972)
Reconnaissance automatique des liens de parent6 traces automatiquement d’arbre g6nAalogique. Mathe‘matique, Znformatique
Thompson Thompson (1978)
Peeling programs for complex pedigreesDepartment of Medical Biophysics and Computing, University of Utah
W. Marshall, S. Buehler, J. Crumley, D. Salmon, M. Landre, G. Fraser (1979)
A familial aggregate of common variable immunodeficiency, Hodgkin disease and other malignancies in Newfoundland--I. Clinical features.Clinical and investigative medicine. Medecine clinique et experimentale, 2 4
R. Newton, S. Buehler, J. Crumley, W. Marshall (1979)
Rhesus Haplotypes in Familial Hodgkin's DiseaseVox Sanguinis, 37
S. Buehler, G. Fodor, W. Marshall, F. Firme, G. Fraser, P. Vaze (1975)
COMMON VARIABLE IMMUNODEFICIENCY, HODGKIN'S DISEASE, AND OTHER MALIGNANCIES IN A NEWFOUNDLAND FAMILYThe Lancet, 305
Marshall Marshall, Buehler Buehler, Crumley Crumley, Salmon Salmon, Landre Landre, Fraser Fraser (1980)
A familial aggregate of Hodgkin's disease, common variable immunodeficiency and other malignancy cases in Newfoundland. I. Clinical featuresClin. Invest. Med., 2
(1980)
Recursive routines for pedigree analysis
Salmon Salmon, Landre Landre, Fraser Fraser, Buehler Buehler, Crumley Crumley, Marshall Marshall (1980)
A familial aggregate of Hodgkin's disease, common variable immunodeficiency and other malignancy cases in Newfoundland. II. Genealogical analysis and conclusions regarding hereditary determinantsClin. Invest. Med., 2
N. Carter, E. Loghem, W. Marshall, R. Newton, C. West (1978)
Serum genetic markers in a Newfoundland isolate with a familial aggregate of Hodgkin's disease.Human heredity, 28 5
D. Salmon, M. Landre, G. Fraser, S. Buehler, J. Crumley, W. Marshall (1979)
A familial aggregate of common variable immunodeficiency, Hodgkin disease and other malignancies in Newfoundland--II. Genealogical analysis and conclusions regarding hereditary determinants.Clinical and investigative medicine. Medecine clinique et experimentale, 2 4
L. Salimonu, D. Bryant, S. Buehler, R. Chandra, J. Crumley, W. Marshall (1980)
Immunoglobulins in familial Hodgkin's disease and immunodeficiency in Newfoundland.International archives of allergy and applied immunology, 63 1
(1974)
The Analysis of Categorical Data. London: Griffin
(1980)
A familial aggregate of Hodgkin’s disease, common variable immunodeficiency and other malignancy
E. Thompson (1980)
Genetic etiology and clusters in a pedigreeHeredity, 45
SUMMARY An extensive Newfoundland genealogy shows a large number of cases of lymphoreticular malignancies. A recessive pattern of inheritance had been previously suggested, but no quantitative investigation of the hypothesis was made. Here we have investigated a variety of aspects of the descent structure of the pedigree and shown that for only a subset of the traits can the inference be upheld. For Hodgkin's disease (HD) and generalized immunodeficiency (ID) there is clear evidence for a recessive HD/ID susceptibility allele. The remainder do not follow this pattern, show no evidence of a single‐locus effect and little of any genetic effect. The ancestry of the HD/ID cases was therefore investigated in detail, and likelihoods computed on the pedigree. These confirmed the recessive nature of the trait, as also did the risk analysis which quite clearly identified the paths of descent taken by the allele. The determination of these paths is a prerequisite for any linkage analysis which might further confirm the single‐locus nature of the trait.
Annals of Human Genetics – Wiley
Published: Jul 1, 1981
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