Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Nicolle, P. Colombo, M. Gallagher, M. Mckinney (1999)
Metabotropic Glutamate Receptor-Mediated Hippocampal Phosphoinositide Turnover Is Blunted in Spatial Learning-Impaired Aged RatsThe Journal of Neuroscience, 19
James McClelland, B. McNaughton, R. O’Reilly (1995)
Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.Psychological review, 102 3
Erin Rand-Giovannetti, E. Chua, Amy Driscoll, D. Schacter, M. Albert, R. Sperling (2006)
Hippocampal and neocortical activation during repetitive encoding in older personsNeurobiology of Aging, 27
V. Murty, F. Sambataro, Saumitra Das, H. Tan, J. Callicott, T. Goldberg, A. Meyer-Lindenberg, D. Weinberger, V. Mattay (2009)
Age-related Alterations in Simple Declarative Memory and the Effect of Negative Stimulus ValenceJournal of Cognitive Neuroscience, 21
R. Newson, E. Kemps (2006)
The Nature of Subjective Cognitive Complaints of Older AdultsThe International Journal of Aging and Human Development, 63
H. Moreno, William Wu, Thomas Lee, A. Brickman, R. Mayeux, T. Brown, S. Small (2007)
Imaging the Aβ-Related Neurotoxicity of Alzheimer DiseaseJAMA Neurology, 64
S. Bookheimer, M. Strojwas, Mark Cohen, A. Saunders, M. Pericak-Vance, J. Mazziotta, G. Small (2000)
Patterns of brain activation in people at risk for Alzheimer's disease.The New England journal of medicine, 343 7
M. Newman, A. Kaszniak (2000)
Spatial Memory and Aging: Performance on a Human Analog of the Morris Water MazeAging, Neuropsychology, and Cognition, 7
R. Cox (1996)
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.Computers and biomedical research, an international journal, 29 3
B. Dickerson, D. Salat, J. Bates, M. Atiya, R. Killiany, D. Greve, A. Dale, C. Stern, D. Blacker, M. Albert, R. Sperling (2004)
Medial temporal lobe function and structure in mild cognitive impairmentAnnals of Neurology, 56
F. Cacucci, M. Yi, Thomas Wills, P. Chapman, J. O’Keefe (2008)
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse modelProceedings of the National Academy of Sciences, 105
Rachel Garoff, S. Slotnick, D. Schacter (2005)
The neural origins of specific and general memory: the role of the fusiform cortexNeuropsychologia, 43
M. Miller, M. Beg, C. Ceritoglu, C. Stark (2005)
Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping.Proceedings of the National Academy of Sciences of the United States of America, 102 27
A. Vazdarjanova, J. Guzowski (2004)
Differences in Hippocampal Neuronal Population Responses to Modifications of an Environmental Context: Evidence for Distinct, Yet Complementary, Functions of CA3 and CA1 EnsemblesThe Journal of Neuroscience, 24
S. Rossitti (2002)
Introduction to Functional Magnetic Resonance Imaging, Principles and TechniquesActa Radiologica, 43
Y. Geinisman, L. Toledo‐Morrell, F. Morrell, I. Persina, M. Rossi (1992)
Age‐related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector techniqueHippocampus, 2
L. Squire, C. Stark, R. Clark (2004)
The medial temporal lobe.Annual review of neuroscience, 27
S. Burke, C. Barnes (2006)
Neural plasticity in the ageing brainNature Reviews Neuroscience, 7
(2004)
Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging.Proceedings of the National Academy of Sciences of the United States of America, 101 18
C. Stark, Yoko Okado (2003)
Making Memories without Trying: Medial Temporal Lobe Activity Associated with Incidental Memory Formation during RecognitionThe Journal of Neuroscience, 23
I. Wilson, S. Ikonen, K. Gurevicius, R. McMahan, M. Gallagher, H. Eichenbaum, H. Tanila (2005)
Place cells of aged rats in two visually identical compartmentsNeurobiology of Aging, 26
J. Leutgeb, S. Leutgeb, M. Moser, E. Moser (2007)
Pattern Separation in the Dentate Gyrus and CA3 of the HippocampusScience, 315
S. Bassett, D. Yousem, C. Cristinzio, Ivana Kusevic, M. Yassa, B. Caffo, S. Zeger (2006)
Familial risk for Alzheimer's disease alters fMRI activation patterns.Brain : a journal of neurology, 129 Pt 5
A. Fleisher, Katherine Podraza, K. Bangen, Curtis Taylor, A. Sherzai, Kunal Sidhar, Thomas Liu, A. Dale, R. Buxton (2009)
Cerebral perfusion and oxygenation differences in Alzheimer's disease riskNeurobiology of Aging, 30
N. Raz, U. Lindenberger, K. Rodrigue, K. Kennedy, D. Head, Adrienne Williamson, Cheryl Dahle, D. Gerstorf, J. Acker (2005)
Regional brain changes in aging healthy adults: general trends, individual differences and modifiers.Cerebral cortex, 15 11
T. Davis, K. Kwong, R. Weisskoff, B. Rosen (1998)
Calibrated functional MRI: mapping the dynamics of oxidative metabolism.Proceedings of the National Academy of Sciences of the United States of America, 95 4
Adam Gazzaley, Steven Siegel, J. Kordower, E. Mufson, John Morrison (1996)
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys.Proceedings of the National Academy of Sciences of the United States of America, 93 7
B. Ances, C. Liang, O. Leontiev, J. Perthen, A. Fleisher, A. Lansing, R. Buxton (2009)
Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulationHuman Brain Mapping, 30
S. Leutgeb, J. Leutgeb, A. Treves, M. Moser, E. Moser (2004)
Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1Science, 305
S. Duverne, Shahab Motamedinia, M. Rugg (2009)
Effects of Age on the Neural Correlates of Retrieval Cue Processing are Modulated by Task DemandsJournal of Cognitive Neuroscience, 21
L. Henkel, Marcia Johnson, D. Leonardis (1998)
Aging and source monitoring: cognitive processes and neuropsychological correlates.Journal of experimental psychology. General, 127 3
M. Penner, Tania Roth, M. Chawla, Lan Hoang, Eric Roth, Farah Lubin, J. Sweatt, Paul Worley, C. Barnes, C. Barnes (2011)
Age-related changes in Arc transcription and DNA methylation within the hippocampusNeurobiology of Aging, 32
(1988)
A Co-Planar Steres Jotactic Atlas of the Human Brain
M. Hasselmo, E. Schnell, E. Barkai (1995)
Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region CA3, 15
R. Sperling (2007)
Functional MRI Studies of Associative Encoding in Normal Aging, Mild Cognitive Impairment, and Alzheimer's DiseaseAnnals of the New York Academy of Sciences, 1097
S. Small, G. Perera, R. DeLaPaz, R. Mayeux, Y. Stern (1999)
Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's diseaseAnnals of Neurology, 45
M. Yassa, C. Stark (2009)
A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobeNeuroImage, 44
J. McGaugh (2004)
The amygdala modulates the consolidation of memories of emotionally arousing experiences.Annual review of neuroscience, 27
T. Hedden, J. Gabrieli (2005)
Healthy and pathological processes in adult development: new evidence from neuroimaging of the aging brainCurrent Opinion in Neurology, 18
H. Moreno, William Wu, Thomas Lee, A. Brickman, R. Mayeux, T. Brown, S. Small (2007)
Imaging the Abeta-related neurotoxicity of Alzheimer disease.Archives of neurology, 64 10
K. Sugaya, R. Greene, D. Personett, Michael Robbins, C. Kent, D. Bryan, E. Skiba, M. Gallagher, M. Mckinney (1998)
Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive declineNeurobiology of Aging, 19
R. Cabeza, S. Daselaar, F. Dolcos, S. Prince, Matthew Budde, L. Nyberg (2004)
Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval.Cerebral cortex, 14 4
I. Wilson, S. Ikonen, M. Gallagher, H. Eichenbaum, H. Tanila (2005)
Age-Associated Alterations of Hippocampal Place Cells Are Subregion SpecificThe Journal of Neuroscience, 25
S. Small, W. Tsai, R. DeLaPaz, R. Mayeux, Y. Stern (2002)
Imaging hippocampal function across the human life span: Is memory decline normal or not?Annals of Neurology, 51
Thressa Smith, M. Adams, M. Gallagher, J. Morrison, P. Rapp (2000)
Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged RatsThe Journal of Neuroscience, 20
I. Wilson, S. Ikonen, R. McMahan, M. Gallagher, Howard Eichenbaum, H. Tanila (2003)
Place cell rigidity correlates with impaired spatial learning in aged ratsNeurobiology of Aging, 24
B. Milner, L. Squire, E. Kandel (1998)
Cognitive Neuroscience and the Study of MemoryNeuron, 20
S. Miller, K. Celone, Kristina Depeau, E. Diamond, B. Dickerson, D. Rentz, M. Pihlajamäki, R. Sperling (2008)
Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activationProceedings of the National Academy of Sciences, 105
Inah Lee, Geeta Rao, J. Knierim (2004)
A Double Dissociation between Hippocampal Subfields Differential Time Course of CA3 and CA1 Place Cells for Processing Changed EnvironmentsNeuron, 42
W. Koutstaal, D. Schacter (1997)
Gist-Based False Recognition of Pictures in Older and Younger AdultsJournal of Memory and Language, 37
O'Reilly O'Reilly, Norman Norman (2002)
Hippocampal and neocortical contributions to memory: Advances in the complementary learning systems frameworkTrends Cogn Sci, 6
M. West (1993)
Regionally specific loss of neurons in the aging human hippocampusNeurobiology of Aging, 14
C. Kirwan, Craig Jones, M. Miller, C. Stark (2007)
High‐resolution fMRI investigation of the medial temporal lobeHuman Brain Mapping, 28
T. McHugh, Matthew Jones, J. Quinn, N. Balthasar, R. Coppari, J. Elmquist, B. Lowell, M. Fanselow, M. Wilson, S. Tonegawa (2007)
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal NetworkScience, 317
S. Burke, C. Barnes (2010)
Senescent synapses and hippocampal circuit dynamicsTrends in Neurosciences, 33
C. Kirwan, C. Stark (2007)
Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe.Learning & memory, 14 9
N. Dennis, S. Hayes, S. Prince, D. Madden, S. Huettel, R. Cabeza (2008)
Effects of aging on the neural correlates of successful item and source memory encoding.Journal of experimental psychology. Learning, memory, and cognition, 34 4
M. Chee, J. Goh, V. Venkatraman, J. Tan, A. Gutchess, B. Sutton, A. Hebrank, E. Leshikar, Denise Park (2006)
Age-related Changes in Object Processing and Contextual Binding Revealed Using fMR AdaptationJournal of Cognitive Neuroscience, 18
O. Lopez, L. Kuller (2009)
Telephone Interview for Cognitive StatusNeuroepidemiology, 34
M. Hasselmo (2006)
The role of acetylcholine in learning and memoryCurrent Opinion in Neurobiology, 16
K. Norman, R. O’Reilly (2003)
Modeling hippocampal and neocortical contributions to recognition memory: a complementary-learning-systems approach.Psychological review, 110 4
T. Hedden, J. Gabrieli (2004)
Insights into the ageing mind: a view from cognitive neuroscienceNature Reviews Neuroscience, 5
K. Celone, V. Calhoun, B. Dickerson, A. Atri, E. Chua, S. Miller, Kristina Depeau, D. Rentz, D. Selkoe, D. Blacker, M. Albert, R. Sperling (2006)
Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer's Disease: An Independent Component AnalysisThe Journal of Neuroscience, 26
S. Miller, E. Fenstermacher, Julie Bates, Deborah Blacker, R. Sperling, Bradford Dickerson (2007)
Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive declineJournal of Neurology, Neurosurgery, and Psychiatry, 79
Opinion TRENDS in Cognitive Sciences Vol.6 No.12 December 2002
I. Wilson, M. Gallagher, H. Eichenbaum, H. Tanila (2006)
Neurocognitive aging: prior memories hinder new hippocampal encodingTrends in Neurosciences, 29
E. Kensinger, D. Schacter (2008)
Neural Processes Supporting Young and Older Adults' Emotional MemoriesJournal of Cognitive Neuroscience, 20
Chelsea Toner, E. Pirogovsky, C. Kirwan, Paul Gilbert (2009)
Visual object pattern separation deficits in nondemented older adults.Learning & memory, 16 5
B. Dickerson, D. Salat, D. Greve, E. Chua, Erin Rand-Giovannetti, D. Rentz, L. Bertram, K. Mullin, R. Tanzi, D. Blacker, M. Albert, R. Sperling (2005)
Increased hippocampal activation in mild cognitive impairment compared to normal aging and ADNeurology, 65
A. Bakker, C. Kirwan, Michael Miller, C. Stark, C. Stark (2008)
Pattern Separation in the Human Hippocampal CA3 and Dentate GyrusScience, 319
J. Jennings, L. Jacoby (1997)
An opposition procedure for detecting age-related deficits in recollection: telling effects of repetition.Psychology and aging, 12 2
S. Daselaar, M. Fleck, I. Dobbins, D. Madden, R. Cabeza (2005)
Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study.Cerebral cortex, 16 12
There is widespread evidence that memory deteriorates with aging, however the exact mechanisms that underlie these changes are not well understood. Given the growing size of the aging population, there is an imperative to study age‐related neurocognitive changes in order to better parse healthy from pathological aging. Using a behavioral paradigm that taxes pattern separation (the ability to differentiate novel yet similar information from previously learned information and thus avoid interference), we investigated age‐related neural changes in the human hippocampus using high‐resolution (1.5 mm isotropic) blood‐oxygenation level‐dependent fMRI. Recent evidence from animal studies suggests that hyperactivity in the CA3 region of the hippocampus may underlie behavioral deficits in pattern separation in aged rats. Here, we report evidence that is consistent with findings from the animal studies. We found a behavioral impairment in pattern separation in a sample of healthy older adults compared with young controls. We also found a related increase in CA3/dentate gyrus activity levels during an fMRI contrast that stresses pattern separation abilities. In a detailed analysis of behavior, we also found that the pattern of impairment was consistent with the predictions of the animal model, where larger changes in the input (greater dissimilarity) were required in order for elderly adults to successfully encode new information as distinct from previously learned information. These findings are also consistent with recent fMRI and behavioral reports in healthy aging, and further suggest that a specific functional deficit in the CA3/dentate network contributes to memory difficulties with aging. © 2010 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Sep 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.