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Parallel Session 17: Coagulation and Thrombosis II

Parallel Session 17: Coagulation and Thrombosis II 504 Activated protein C levels generated by GalT‐KO PAEC expressing human endothelial protein C receptor and thrombomodulin in the early stage of interaction with human protein C and thrombin Cristiana Bulato 1 , Claudia Maria Radu 1 , Sabrina Gavasso 1 , Cesare Galli 2 , Andrea Perota 2 , Federica Besenzon 3 , Emanuele Cozzi 3 , Paolo Simioni 1 1 Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua, Padua, Italy; 2 Laboratorio di Tecnologie della Riproduzione, Avantea, Cremona; 3 Consortium for Research on Organ Transplantation, CORIT, Padua, Italy Introduction: Kidneys from GalT‐KO pigs are rejected when transplanted into primates, due to the formation of thrombi in the microvasculature. Thrombosis could be prevented by the co‐expression on vascular endothelium of these transgenic pigs of two human anticoagulant proteins, endothelial protein C receptor (EPCR) and thrombomodulin (TM), which are involved in the activation of protein C (PC). Aim of the Study: We have already demonstrated that GalT‐KO PAEC, expressing both human EPCR and TM, activate human PC more efficiently than PAEC expressing only one receptor. This result is observed after incubation of cells with human PC and thrombin for long periods (1–4 h). Aim of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Parallel Session 17: Coagulation and Thrombosis II

Xenotransplantation , Volume 18 (5) – Sep 1, 2011
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Publisher
Wiley
Copyright
© 2011 John Wiley & Sons A/S
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/j.1399-3089.2011.00660.x
Publisher site
See Article on Publisher Site

Abstract

504 Activated protein C levels generated by GalT‐KO PAEC expressing human endothelial protein C receptor and thrombomodulin in the early stage of interaction with human protein C and thrombin Cristiana Bulato 1 , Claudia Maria Radu 1 , Sabrina Gavasso 1 , Cesare Galli 2 , Andrea Perota 2 , Federica Besenzon 3 , Emanuele Cozzi 3 , Paolo Simioni 1 1 Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua, Padua, Italy; 2 Laboratorio di Tecnologie della Riproduzione, Avantea, Cremona; 3 Consortium for Research on Organ Transplantation, CORIT, Padua, Italy Introduction: Kidneys from GalT‐KO pigs are rejected when transplanted into primates, due to the formation of thrombi in the microvasculature. Thrombosis could be prevented by the co‐expression on vascular endothelium of these transgenic pigs of two human anticoagulant proteins, endothelial protein C receptor (EPCR) and thrombomodulin (TM), which are involved in the activation of protein C (PC). Aim of the Study: We have already demonstrated that GalT‐KO PAEC, expressing both human EPCR and TM, activate human PC more efficiently than PAEC expressing only one receptor. This result is observed after incubation of cells with human PC and thrombin for long periods (1–4 h). Aim of the

Journal

Xenotransplantation – Wiley

Published: Sep 1, 2011

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