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Palladium‐Catalyzed Asymmetric [4+3]‐Cyclization Reaction of Fused 1‐Azadienes with Amino‐trimethylenemethanes: Highly Stereoselective Construction of Chiral Fused Azepines

Palladium‐Catalyzed Asymmetric [4+3]‐Cyclization Reaction of Fused 1‐Azadienes with... A Pd‐catalyzed asymmetric aromative [4+3]‐cyclization reaction of amino‐trimethylenemethanes (TMM, 1,3‐dipoles) with fused 1‐azadienes has been developed. This method enables access to the synthetically importance and biologically active benzofuran fused azepines and indeno‐azepines in excellent efficiency and stereoselectivity (up to 95% yield, 99% ee, >19 : 1 dr). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chinese Journal of Chemistry Wiley

Palladium‐Catalyzed Asymmetric [4+3]‐Cyclization Reaction of Fused 1‐Azadienes with Amino‐trimethylenemethanes: Highly Stereoselective Construction of Chiral Fused Azepines

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References (66)

Publisher
Wiley
Copyright
© 2020 SIOC, CAS, Shanghai, & WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
1001-604X
eISSN
1614-7065
DOI
10.1002/cjoc.201900430
Publisher site
See Article on Publisher Site

Abstract

A Pd‐catalyzed asymmetric aromative [4+3]‐cyclization reaction of amino‐trimethylenemethanes (TMM, 1,3‐dipoles) with fused 1‐azadienes has been developed. This method enables access to the synthetically importance and biologically active benzofuran fused azepines and indeno‐azepines in excellent efficiency and stereoselectivity (up to 95% yield, 99% ee, >19 : 1 dr).

Journal

Chinese Journal of ChemistryWiley

Published: Feb 1, 2020

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